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Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren. Aliskiren is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone system which plays a role in blood pressure control. Renin cleaves angiotensinogen to angiotensin I, which is in turn converted by (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstriction and increased blood pressure. Angiotensin II also stimulates the production of aldosterone from the adrenal cortex, which causes the tubules of the kidneys to increase reabsorption of sodium, with water following thereby increasing plasma volume and blood pressure. Aliskiren binds to the S3bp binding pocket of renin, essential for its activity. Binding to this pocket prevents the conversion of angiotensinogen to angiotensin I. Aliskiren is also available as combination therapy with hydrochlorothiazide.

June 21, 2017

prudect name : Aliskiren hemifumarate is a hemifumarate salt form of Aliskiren. Aliskiren is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme…

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AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.

prudect name : AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.AP23848 PF-562771 Synonyms: CAS NO: 834894-21-2Molecular Formula: C30H38N5O2PMolecular Weight:…

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APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.

prudect name : APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.APD668 Synonyms: CAS NO: 832714-46-2Molecular Formula: C21H24FN5O5SMolecular Weight: 477.51Purity:…

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AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.

prudect name : AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and

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prudect name : Ametantrone(NSC 196473)Synonyms: CAS NO: 64862-96-0Molecular Formula: C26H36N4O8Molecular Weight: 532.59Purity: 98% minSolubility: in

prudect name : Ametantrone(NSC 196473) Synonyms: CAS NO: 64862-96-0Molecular Formula: C26H36N4O8Molecular Weight: 532.59Purity: 98% minSolubility: in DMSOStorage: -20oC 1243244-14-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496773

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Abiraterone Acetate (CB 7630) is a highly active and selective 17¦Á-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of 72 nM. Abiraterone Acetate (CB 7630) inhibitor CYP11B1, CYP11B2 and CYP3A4 with IC50 of 1.6, 1.8 and 2.7 ¦ÌM. Abiraterone Acetate (CB 7630) is used in the study of castration-resistant prostate cancer. Abiraterone Acetate (CB 7630) blocks the formation of testosterone by inhibiting CYP17A1. Abiraterone Acetate (CB 7630) caused significant reductions in the weights of the ventral prostate and seminal vesicles. There was no reduction seen in the weight of these organs with KC. Abiraterone Acetate (CB 7630) reduced plasma testosterone to 0.1 nM or less, despite a three- to four-fold increase in the plasma level of luteinizing hormone (LH).

prudect name : Abiraterone Acetate (CB 7630) is a highly active and selective 17¦Á-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of 72 nM. Abiraterone Acetate (CB 7630) inhibitor CYP11B1, CYP11B2…

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AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85 phosphorylation and p-13 kinase activation. AG-490 is an inhibitor of JAK3.

prudect name : AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been…

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ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.

prudect name : ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.ATB 346 Synonyms: CAS NO: 1226895-20-0Molecular Formula: C21H19NO3SMolecular Weight: 365.45Purity: 98% minSolubility: in DMSOStorage: -20oC…

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prudect name : 9,10-Di(2-naphthyl)anthraceneSynonyms: ¦Â-ADNCAS NO: 122648-99-1Molecular Formula: C34H22Molecular Weight: 430.55Purity: 99% minSolubility: Storage:

prudect name : 9,10-Di(2-naphthyl)anthracene Synonyms: ¦Â-ADNCAS NO: 122648-99-1Molecular Formula: C34H22Molecular Weight: 430.55Purity: 99% minSolubility: Storage: 763113-22-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496667

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prudect name : 9-Amino minocycline hydrochlorideSynonyms: CAS NO: 149934-21-4Molecular Formula: C23H28N4O7.HClMolecular Weight: 508.95Purity: ≥98%Solubility: Storage:

prudect name : 9-Amino minocycline hydrochloride Synonyms: CAS NO: 149934-21-4Molecular Formula: C23H28N4O7.HClMolecular Weight: 508.95Purity: ≥98%Solubility: Storage: −20°C 2 years 34233-69-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496604

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