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prudect name : AN-2690(Tavaborole)Synonyms: 5-Fluoro-2,1-Benzoxaborol-1(3H)-OlCAS NO: 174671-46-6Molecular Formula: C7H6BFO2Molecular Weight: 151.93Purity: 98% minSolubility: in DMSOStorage:

June 21, 2017

prudect name : AN-2690(Tavaborole) Synonyms: 5-Fluoro-2,1-Benzoxaborol-1(3H)-OlCAS NO: 174671-46-6Molecular Formula: C7H6BFO2Molecular Weight: 151.93Purity: 98% minSolubility: in DMSOStorage: -20oC 371935-79-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497103

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Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 ¦ÌM, high selectivity over other key metabolic lipases.

prudect name : Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 ¦ÌM, high selectivity over other key metabolic lipases.Atglistatin Synonyms: CAS…

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A-803467 potently blocks recombinant human or rat NaV1.8 channels with IC50 of 8 nM and 45 nM, respectively, at a holding potential of -40 mV. At a resting state, A-803467 also potently blocks human NaV1.8 channels with IC50 of 79 nM. A-803467 blocks tetrodotoxin-resistant (TTX-R) currents in rat dorsal root ganglion neurons in a concentration-dependent manner with IC50 of 140 nM, more potently compared with both mexiletine and lamotrigine with IC50 of >30 ¦ÌM. A-803467 displays 300- to 1,000-fold higher selectivity for hNaV1.8 over hNaV1.2, hNaV1.3, hNaV1.5, and hNaV1.7 channels with IC50 of 7.38 ¦ÌM, 2.45 ¦ÌM, 7.34 ¦ÌM, and 6.74 ¦ÌM, respectively. A-803467 shows no significant activity against other channels and receptors expressed in peripheral sensory neurons including TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels with IC50 >10 ¦ÌM. A-803467 also shows no or weak activity against a broad screening panel of cell-surface receptors, ion channels, and enzymes with IC50 of >2 ¦ÌM. A-803467 at 0.3 ¦ÌM but not 0.1 ¦ÌM significantly inhibits the generation of spontaneous and electrically evoked action potentials. [

prudect name : A-803467 potently blocks recombinant human or rat NaV1.8 channels with IC50 of 8 nM and 45 nM, respectively, at a holding potential of -40 mV. At a…

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prudect name : AN 2728Synonyms: CAS NO: 906673-24-3Molecular Formula: C14H10BNO3Molecular Weight: 251.05Purity: 98% minSolubility: in

prudect name : AN 2728 Synonyms: CAS NO: 906673-24-3Molecular Formula: C14H10BNO3Molecular Weight: 251.05Purity: 98% minSolubility: in DMSOStorage: -20oC 1233339-22-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496947

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prudect name : ARRY-543Synonyms: ARRY-543CAS NO: 114629-86-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage:

prudect name : ARRY-543 Synonyms: ARRY-543CAS NO: 114629-86-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage: −20°C 1229208-44-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496848

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An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.

prudect name : An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the…

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ASP3026, a novel and selective inhibitor for the ALK kinase.

prudect name : ASP3026, a novel and selective inhibitor for the ALK kinase.ASP 3026 Synonyms: CAS NO: 1097917-15-1Molecular Formula: C29H40N8O3SMolecular Weight: 580.74Purity: 98% minSolubility: In DMSOStorage: −20°C 1222998-36-8 References PubMed…

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Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error in a strand of the DNA.IC50 (¦ÌM):PARP-1= 0.005,PARP-2= 0.001 , PF50=25.8.AZD2281(Olaparib) at 400 mg twice daily is well tolerated and highly active. The toxicity that was seen in BRCA1/BRCA2 carriers was similar to the previously reported toxicity in noncarriers

prudect name : Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error…

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Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone (CB-7598, CB7598, CB 7598) is currently undergoing phase II clinical trials as a potential compound for the treatment of prostate cancer. In preclinical studies, abiraterone (CB-7598, CB7598, CB 7598) has demonstrated the ability to selectively inhibit the target enzyme, resulting in inhibition of testosterone production in both the adrenals and the testes. Clinical studies demonstrated that CYP17 blockade by abiraterone acetate is safe and has significant antitumor activity in CRPC (castration-resistant prostate cancer).

prudect name : Abiraterone (CB-7598, CB7598, CB 7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone (CB-7598, CB7598, CB 7598) is currently…

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Biological Activity Allosteric modulator of IRE1¦Á. Inhibits IRE1¦Á autophosphorylation (IC50 = 280 nM) and activates IRE1¦Á RNase activity.

prudect name : Biological Activity Allosteric modulator of IRE1¦Á. Inhibits IRE1¦Á autophosphorylation (IC50 = 280 nM) and activates IRE1¦Á RNase activity.APY 29 Synonyms: CAS NO: 1216665-49-4Molecular Formula: C17H16N8Molecular Weight: 332.36Purity:…

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