Abacavir sulfate for human immunodeficiency virus (HIV) infection in antiretroviral combination therapy.

 June 21, 2017

prudect name : Abacavir sulfate for human immunodeficiency virus (HIV) infection in antiretroviral combination therapy.Abacavir sulfate Synonyms: CAS NO: 188062-50-2Molecular Formula: C14H18N6O.H2SO4Molecular Weight: 384.41Purity: 99%Solubility: Storage: −20°C 2 years 228266-40-8…

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ADL-5859 is an agonist agents that selectively stimulate the ¦Ä-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition, Delta agonists are thought to modulate other biological processes that may manifest themselves in disease states or conditions such as overactive bladder and depression

prudect name : ADL-5859 is an agonist agents that selectively stimulate the ¦Ä-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition,…

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AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively. AZ960 was also shown to be active against other kinases, including TrkA, Aurora-A, and FAK, with IC50 of around 0.1 ¦ÌM. AZ960, a novel inhibitor of Jak2 kinase, effectively induced growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1¨Cinfected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1. Interestingly, AZ960 increased levels of Bcl-xL in MT-1 and MT-2 cells in association with accumulation of cAMP response element-binding protein bound to the Bcl-xL promoter as measured by chromatin immunoprecipitation assay. Importantly, genetic inhibition of Bcl-xL by a small interfering RNA potentiated antiproliferative effects of AZ960 in MT-1 cells.

prudect name : AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively. AZ960 was also…

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prudect name : Amphotericin BSynonyms: CAS NO: 1397-89-3Molecular Formula: C47H73NO17Molecular Weight: 924.08Purity: 95% minSolubility: Storage:

prudect name : Amphotericin B Synonyms: CAS NO: 1397-89-3Molecular Formula: C47H73NO17Molecular Weight: 924.08Purity: 95% minSolubility: Storage: −20°C 1627503-67-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497546

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Biological Activity Potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 ¦ÌM. Reduces nociception in animal models of persistent neuropathic and inflammatory pain.

prudect name : Biological Activity Potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety…

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AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 ¦ÌM for acute lymphoblastic leukemia (697) cell lines.In chronic lymphocytic leukemia (CLL) cells, the 48-hr LC50 of AR-42 is 0.76 ¦ÌM. AR-42 produces dose- and time-dependent acetylation both of histones and tubulin, and induces caspase-dependent apoptosis that is not reduced in the presence of stromal cells. AR-42 significantly reduced leukocyte counts and/or prolonged survival in three separate mouse models of B-cell malignancy without evidence of toxicity. AR-42 has in vitro and in vivo efficacy at tolerable doses. In additon, AR-42 promoted hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. Down-regulation of Kit occurred after AR-42 treatment via inhibition of Kit transcription.

prudect name : AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 ¦ÌM for acute lymphoblastic leukemia (697) cell lines.In chronic lymphocytic leukemia (CLL) cells, the 48-hr LC50…

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prudect name : AlovudineSynonyms: CAS NO: 25526-93-6Molecular Formula: C10H13FN2O4Molecular Weight: 244.22Purity: 99%Solubility: Storage: -20¡æ

prudect name : Alovudine Synonyms: CAS NO: 25526-93-6Molecular Formula: C10H13FN2O4Molecular Weight: 244.22Purity: 99%Solubility: Storage: -20¡æ 195733-43-8 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497484

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Biological Activity of AZD8055: AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

prudect name : Biological Activity of AZD8055: AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of…

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Chemical Name: (-)-1,1¡¯,6,6¡¯,7,7¡¯-Hexahydroxy-3,3¡¯-dim­ethyl-5,5¡¯-bis(1-methylethyl)-[2,2¡¯-binaphthalene]-8­,8¡¯-dicarboxaldehyde

prudect name : Chemical Name: (-)-1,1¡¯,6,6¡¯,7,7¡¯-Hexahydroxy-3,3¡¯-dim­ethyl-5,5¡¯-bis(1-methylethyl)-[2,2¡¯-binaphthalene]-8­,8¡¯-dicarboxaldehydeAT 101 Synonyms: (-)-GossypolCAS NO: 90141-22-3Molecular Formula: C30H30O8Molecular Weight: 518.55Purity: 98% minSolubility: In DMSOStorage: -20°C 851983-85-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497260

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AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.

prudect name : AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous…

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