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AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models

June 21, 2017

prudect name : AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent modelsAWD 131-13 Synonyms: ImepitoinCAS NO: 188116-07-6Molecular Formula: C13H14ClN3O2Molecular Weight:…

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Aprepitant is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by blocking the neurokinin 1 (NK1) receptor. Aprepitant is used for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

prudect name : Aprepitant is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by blocking the neurokinin 1…

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Anidulafungin is the third generation of spines white semi-synthetic antifungal antimicrobial class is a derivative of amphotericin B.

prudect name : Anidulafungin is the third generation of spines white semi-synthetic antifungal antimicrobial class is a derivative of amphotericin B.Anidulafungin Synonyms: CAS NO: 166663-25-8Molecular Formula: C58H73N7O17Molecular Weight: 1140.24Purity: 99%Solubility:…

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Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer¡¯s disease, schizophrenia and mild cognitive impairment (MCI).

prudect name : Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer¡¯s disease, schizophrenia…

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AR 0133418; AR 014418; AR-AO 14418; GSK 3B Inhibitor VIII; GSK 3beta inhibitor VIII is a selective and effective GSK3¦Â inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.

prudect name : AR 0133418; AR 014418; AR-AO 14418; GSK 3B Inhibitor VIII; GSK 3beta inhibitor VIII is a selective and effective GSK3¦Â inhibitor with an IC 50 value of…

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prudect name : Atorvastatin sodium saltSynonyms: CAS NO: 134523-01-6Molecular Formula: C33H34FN2O5.NaMolecular Weight: 580.62Purity: 98% minSolubility:

prudect name : Atorvastatin sodium salt Synonyms: CAS NO: 134523-01-6Molecular Formula: C33H34FN2O5.NaMolecular Weight: 580.62Purity: 98% minSolubility: In DMSOStorage: -20°C 154229-18-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497879

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17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG HCl demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG HCl and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability.

prudect name : 17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding…

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The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of pain associated with inflammatory diseases and cancer. AMG 517 is a potent and selective transient receptor potential vanilloid-1 (TRPV1) antagonist. AMG 517 was selected as a second-generation candidate for further evaluation in human clinical trials as a potential new treatment for chronic pain.

prudect name : The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of pain associated with inflammatory diseases and cancer. AMG 517 is a potent…

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Asenapine (Saphris) is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic ¦Á1 (8.9), ¦Á2A (8.9), ¦Á2B (9.5), and ¦Á2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors.

prudect name : Asenapine (Saphris) is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine shows high affinity (pKi) for numerous…

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4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidine

prudect name : 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidineAT 56 Synonyms: CAS NO: 162640-98-4Molecular Formula: C25H27N5Molecular Weight: 397.52Purity: 98% minSolubility: in DMSOStorage: -20oC 6809-52-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497713

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