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Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

June 21, 2017

prudect name : Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist…

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ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. In preclinical studies, ABT-751 showed antitumor activity against a broad spectrum of tumor lines and human xenograft models (colon, nasopharyngeal,lung, stomach, breast, pancreas, prostate). ABT-751 is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. ABT-751 also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. ABT-751 is currently under clinical development for cancer treatment.

prudect name : ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds…

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AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37 nM. AZD1152 is converted rapidly to the active AZD1152-HQPA (Barasertib) in plasma. AZD1152-HQPA (Barasertib) has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA (Barasertib) to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.

prudect name : AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37…

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prudect name : ArgirelineSynonyms: CAS NO: 616204-22-9Molecular Formula: C34H60N14O12SMolecular Weight: 888.99Purity: 98% minSolubility: Storage: -20°C

prudect name : Argireline Synonyms: CAS NO: 616204-22-9Molecular Formula: C34H60N14O12SMolecular Weight: 888.99Purity: 98% minSolubility: Storage: -20°C 139504-50-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498740/

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prudect name : Angiotensin acetateSynonyms: CAS NO: 58-49-1Molecular Formula: C49H70N14O11Molecular Weight: 1031.17Purity: 98% minSolubility: In

prudect name : Angiotensin acetate Synonyms: CAS NO: 58-49-1Molecular Formula: C49H70N14O11Molecular Weight: 1031.17Purity: 98% minSolubility: In DMSOStorage: -20°C 60940-34-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498717

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AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp

prudect name : AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by PgpAZD2461 Synonyms: CAS NO: 1174043-16-3Molecular Formula: C22H22FN3O3Molecular Weight: 395.43Purity: 98%…

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(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

prudect name : (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamideApremilast enantiomer Synonyms: CAS NO: 608141-44-2Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: In DMSOStorage: -20 oC 338967-87-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498625

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Argatroban is a thrombin inhibitor, reversibly combine with the active site of thrombin.

prudect name : Argatroban is a thrombin inhibitor, reversibly combine with the active site of thrombin.Argatroban Synonyms: CAS NO: 141396-28-3Molecular Formula: C23H36N6O5S.H2OMolecular Weight: 526.65Purity: 99%Solubility: Storage: −20°C 2 years 229975-97-7…

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AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-252424 inhibits human recombinant PI3K¦Â, and ¦Ä with IC50 values of 20,000, and 20,000 nM, respectively. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 µM. AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg in a mouse model of peritonitis

prudect name : AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation…

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MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 ¦ÌM. MP-470 reduced c-Met phosphorylation and enhanced radiation-induced cell kill by 0.4 logs in SF767 cells. Cells pretreated with MP-470 had more ds DNA damage than cells treated with radiation alone. Mechanistically, MP-470 was shown to inhibit dsDNA break repair and increase apoptosis.

prudect name : MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 ¦ÌM. MP-470…

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