prudect name : alpha,alpha-Diphenyl-4-piperidinomethanolSynonyms: CAS NO: 115-46-8Molecular Formula: C18H21NOMolecular Weight: 267.37Purity: 99%Solubility: Storage: −20°C

June 21, 2017

prudect name : alpha,alpha-Diphenyl-4-piperidinomethanol Synonyms: CAS NO: 115-46-8Molecular Formula: C18H21NOMolecular Weight: 267.37Purity: 99%Solubility: Storage: −20°C 2 years 2450-53-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502589

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Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy.

prudect name : Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy.Andarine (GTx-007) Synonyms: CAS NO:…

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ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM, 80 nM and 80 nM, respectively. ABT-737 induces apoptosis in HL60 cells, which due to decreased Bcl-2/Bax heterodimerization and has no effect on cell cycle distribution. ABT-737 also induces cytochrome c release from purified mitochondria and promotes conformational changes in Bax that are associated with apoptosis.

prudect name : ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM,…

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Anacetrapib is not only able to increase HDL-cholesterol, but also further decreases LDL-cholesterol when taken in combination with a statin. Anacetrapib dose-dependently and significantly decreases the transfer of CE from HDL3 to HDL2. Anacetrapib doesn¡¯t affect the amount of [14C]-dalcetrapibthiol bound to rhCETP. Anacetrapib decreases pre-¦Â-HDL formation by more than 46%.Anacetrapib potently blocks CE and TG transfer in 95% human serum.

prudect name : Anacetrapib is not only able to increase HDL-cholesterol, but also further decreases LDL-cholesterol when taken in combination with a statin. Anacetrapib dose-dependently and significantly decreases the transfer…

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prudect name : AzathioprineSynonyms: CAS NO: 446-86-6Molecular Formula: C9H7N7O2SMolecular Weight: 277.26Purity: 99%Solubility: Storage: −20°C

prudect name : Azathioprine Synonyms: CAS NO: 446-86-6Molecular Formula: C9H7N7O2SMolecular Weight: 277.26Purity: 99%Solubility: Storage: −20°C 2 years 129-56-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502492

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AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects in vitro and in vivo. Antitumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer, and PTEN-deficient MES-SA uterine tumor xenografts was shown. We show for the first time that induction of AKT phosphorylation at serine 473 by AT13148, as reported for other ATP-competitive inhibitors of AKT, is not a therapeutically relevant reactivation step. Gene expression studies showed that AT13148 has a predominant effect on apoptosis genes, whereas the selective AKT inhibitor CCT128930 modulates cell-cycle genes. Induction of upstream regulators including IRS2 and PIK3IP1 as a result of compensatory feedback loops was observed.

prudect name : AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in a concentration and time-dependent manner in cancer cells with clinically…

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AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity. AZD3514 is being evaluated in a Phase I clinical trial in patients with castrate-resistant prostate cancer.

prudect name : AZD-3514 is a potent androgen receptor downregulator with potential anticancer cancer activity. AZD3514 is being evaluated in a Phase I clinical trial in patients with castrate-resistant prostate…

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Antibiotic C 15003P3; Maytansinol isobutyrate; NSC 292222; 2¡¯-De(acetylmethylamino)-2¡¯-methylmaytansine

prudect name : Antibiotic C 15003P3; Maytansinol isobutyrate; NSC 292222; 2¡¯-De(acetylmethylamino)-2¡¯-methylmaytansineAnsamitocin P 3 Synonyms: CAS NO: 66584-72-3Molecular Formula: C32H43ClN2O9Molecular Weight: 635.14Purity: 98% minSolubility: In DMSOStorage: -20°C 2627-69-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502302

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AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML.

prudect name : AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing…

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prudect name : AltrenogestSynonyms: CAS NO: 850-52-2Molecular Formula: C21H26O2Molecular Weight: 310.43Purity: 99% minSolubility: Storage: −20°C

prudect name : Altrenogest Synonyms: CAS NO: 850-52-2Molecular Formula: C21H26O2Molecular Weight: 310.43Purity: 99% minSolubility: Storage: −20°C 154229-19-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502225

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