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Synonyms:(7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy–D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione;(7S)-9¦Â-Amino-9-acetyl-7¦Â-[(2-deoxy-¦Â-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-¦Â-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione;(7S,9S)-9-Amino-9-acetyl-7-[(2-deoxy-¦Â-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;Amurubicin;5,12-Naphthacenedione,9-acetyl-9-aMino-7-(2-deoxy-b-D-erythro-pentopyranosyl)oxy-7,8,9,10-tetrahydro-6,11-dihydroxy-,(7S,9S)-

June 21, 2017

prudect name : Synonyms:(7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy–D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione;(7S)-9¦Â-Amino-9-acetyl-7¦Â-[(2-deoxy-¦Â-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-¦Â-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione;(7S,9S)-9-Amino-9-acetyl-7-[(2-deoxy-¦Â-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;Amurubicin;5,12-Naphthacenedione,9-acetyl-9-aMino-7-(2-deoxy-b-D-erythro-pentopyranosyl)oxy-7,8,9,10-tetrahydro-6,11-dihydroxy-,(7S,9S)-Amrubicin Synonyms: CAS NO: 110267-81-7Molecular Formula: C25H25NO9Molecular Weight: 483.47Purity: 98% minSolubility: In DMSOStorage: -20°C 91037-65-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502848

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Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.

prudect name : Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone…

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Inhibit xanthine oxidase to uric acid into a reduced, lower blood uric acid levels, reduce uric acid salts in the bones, joints and kidneys of calm, for gout, gouty nephropathy.

prudect name : Inhibit xanthine oxidase to uric acid into a reduced, lower blood uric acid levels, reduce uric acid salts in the bones, joints and kidneys of calm, for…

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AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Inhibition of Jak2 activity is associated with abrogation of Stat3 nuclear translocation and tumorigenesis. AZD1480 suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.AZD1480 inhibited the phosphorylation of Stat5 with an IC50 of 46 nM in TEL-Jak2 cells, whereas little or no inhibition of Stat5 phosphorylation was observed in the TEL-Jak3, TEL-Jak1, or TEL-Tyk2 cells at or below 1 ¦ÌM AZD1480.

prudect name : AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. Inhibition of Jak2 activity is associated with abrogation of Stat3 nuclear translocation and…

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AS-604850 is a selective, ATP-competitive PI3K¦Ã inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant ¦Ã, ¦Ä, ¦Â, and ¦Á isoforms, respectively. AS-604850 shows no notable activity against a wide array of protein kinases at 1 ¦ÌM. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

prudect name : AS-604850 is a selective, ATP-competitive PI3K¦Ã inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant ¦Ã, ¦Ä, ¦Â, and ¦Á isoforms, respectively….

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AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively. In proliferation assays, AZD8931 was significantly more potent than gefitinib or lapatinib in specific squamous cell carcinoma of the head and neck and non-small cell lung carcinoma cell lines. In vivo, AZD8931 inhibited xenograft growth in a range of models while significantly affecting EGFR, erbB2, and erbB3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. It has a unique pharmacologic profile providing equipotent inhibition of EGFR, erbB2, and erbB3 signaling and showing greater antitumor activity than agents with a narrower spectrum of erbB receptor inhibition in specific preclinical models.

prudect name : AZD8931 is a novel potent reversible small molecule epidermal growth factor receptor, ERBB2 (HER2) and ERBB3 inhibitor with an IC50 of 4, 3, 4 nM, respectively. In…

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prudect name : Amiodarone hydrochlorideSynonyms: CAS NO: 199774-82-4Molecular Formula: C25H29I2NO3.ClHMolecular Weight: 681.77Purity: 99%Solubility: In DMSOStorage:

prudect name : Amiodarone hydrochloride Synonyms: CAS NO: 199774-82-4Molecular Formula: C25H29I2NO3.ClHMolecular Weight: 681.77Purity: 99%Solubility: In DMSOStorage: −20°C 2 years 174022-42-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502705

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A-796260 is a synthetic cannabinoid (CB) that shows high selectivity for the CB2 receptor (Ki = 0.77 nM) over the CB1 receptor (Ki = 2,100 nM).

prudect name : A-796260 is a synthetic cannabinoid (CB) that shows high selectivity for the CB2 receptor (Ki = 0.77 nM) over the CB1 receptor (Ki = 2,100 nM).A 796260…

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prudect name : AzatadinemaleateSynonyms: CAS NO: 3978-86-7Molecular Formula: C28H30N2O8Molecular Weight: 522.551Purity: 99%Solubility: Storage: −20°C

prudect name : Azatadinemaleate Synonyms: CAS NO: 3978-86-7Molecular Formula: C28H30N2O8Molecular Weight: 522.551Purity: 99%Solubility: Storage: −20°C 2 years 33069-62-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502659

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AST1306 is a novel anilino-quinazoline compound, which inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. In vivo, AST1306 potently suppressed tumor growth in ErbB2-overexpressing adenocarcinoma xenograft and FVB-2/N(neu) transgenic breast cancer mouse models, but weakly inhibited the growth of EGFR-overexpressing tumor xenografts. Tumor growth inhibition induced by a single dose of AST1306 in the SK-OV-3 xenograft model was accompanied by a rapid (within 2 h) and sustained (≥24 h) inhibition of both EGFR and ErbB2, consistent with an irreversible inhibition mechanism. Taken together, these results establish AST1306 as a selective, irreversible ErbB2 and EGFR inhibitor whose growth-inhibitory effects are more potent in ErbB2-overexpressing cells.

prudect name : AST1306 is a novel anilino-quinazoline compound, which inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in…

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