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BIBF1120 inhibits PDGFR kinase activity of PDGFR alpha and PDGFR beta types with IC50 values of 59 and 65 nM, respectively. In addition, BIBF1120 suppresses the FGFR subtypes with IC50 of 60, 37 and 108 nM for FGFR1, FGFR2, and FGFR3, respectively. BIBF1120 binds to the ATP-binding site in the cleft between the amino and carboxy terminal lobes of the kinase domain. The indolinone scaffold forms two hydrogen bonds with the backbone nitrogen of Cys919 and the backbone carbonyl oxygen of Glu917 in the hinge region. BIBF 1120 inhibits proliferation of PDGF-BB stimulated BRPs with an EC50 of 79 nM in cell assays. BIBF1120 at concentrations as low as 100 nM blocks activation of MAPK after stimulation with 5% serum plus PDGF-BB. In cultures of human vascular smooth muscle cells (HUASMC), BIBF1120 prevents PDGF-BB stimulated proliferation with an EC50 of 69 nM.

June 21, 2017

prudect name : BIBF1120 inhibits PDGFR kinase activity of PDGFR alpha and PDGFR beta types with IC50 values of 59 and 65 nM, respectively. In addition, BIBF1120 suppresses the FGFR…

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prudect name : BenzbromaroneSynonyms: CAS NO: 3562-84-3Molecular Formula: C17H12Br2O3Molecular Weight: 424.08Purity: 99%Solubility: Storage: −20°C

prudect name : Benzbromarone Synonyms: CAS NO: 3562-84-3Molecular Formula: C17H12Br2O3Molecular Weight: 424.08Purity: 99%Solubility: Storage: −20°C 2 years CJ-023423 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505192

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Bicalutamide capsules for the treatment of advanced prostate cancer, anti-cancer drug

prudect name : Bicalutamide capsules for the treatment of advanced prostate cancer, anti-cancer drugBicalutamide Synonyms: CAS NO: 90357-06-5Molecular Formula: C18H14F4N2O4SMolecular Weight: 430.37Purity: 99%Solubility: Storage: −20°C 2 years Z-VAD(OMe)-FMK References PubMed…

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Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.

prudect name : Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM,…

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BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 ¦Ìmol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 ¦Ìmol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.

prudect name : BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell...

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Brexpiprazole is a novel D2 dopamine partial agonist.

prudect name : Brexpiprazole is a novel D2 dopamine partial agonist.Brexpiprazole Synonyms: CAS NO: 913611-97-9Molecular Formula: C25H27N3O2SMolecular Weight: 433.57Purity: 98% minSolubility: In DMSOStorage: -20 oC ABT-627 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505087

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BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.

prudect name : BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.BMS 626529 Synonyms: CAS NO: 701213-36-7Molecular Formula: C24H23N7O4Molecular Weight: 473.48Purity:…

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is the treatment of eye drops and ocular hypertension open-angle glaucoma relief elevated intraocular pressure in patients with a better drug

prudect name : is the treatment of eye drops and ocular hypertension open-angle glaucoma relief elevated intraocular pressure in patients with a better drugBrinzolamide Synonyms: CAS NO: 138890-62-7Molecular Formula: C12H21N3O5S3Molecular…

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prudect name : BusulfanSynonyms: CAS NO: 55-98-1Molecular Formula: C6H14O6S2Molecular Weight: 246.29Purity: 99%Solubility: Storage: −20°C

prudect name : Busulfan Synonyms: CAS NO: 55-98-1Molecular Formula: C6H14O6S2Molecular Weight: 246.29Purity: 99%Solubility: Storage: −20°C 2 years GFT505 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504903

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BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively

prudect name : BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectivelyBLU9931 Synonyms: CAS NO: 1538604-68-0Molecular…

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