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PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas and about eight percent of all solid tumors. [2] BRAF mutant melanoma cell strains were highly sensitive to PLX4032 with IC50 in the nM range (60¨C450 nM), whereas BRAF wild-type cells were resistant, with IC50 2.4 ¦ÌM or above.

June 21, 2017

prudect name : PLX4032 is a highly selective inhibitor of BRAF kinase activity, with an IC50 of 44 nmol/L against V600E-mutant BRAF. [1] BRAFV600E cancer-causing mutation occurs in most melanomas…

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Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

prudect name : Vinorelbine(KW-2307 base) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.Vinorelbine tartrate Synonyms: CAS NO: 125317-39-7Molecular Formula: C45H54N4O8.2(C4H6O6);C53H66N4O20Molecular Weight: 1079.12Purity:…

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prudect name : VRT752271Synonyms: CAS NO: 869886-67-9Molecular Formula: C21H23CI3N4O2Molecular Weight: 469.79Purity: 98% minSolubility: In DMSOStorage:

prudect name : VRT752271 Synonyms: CAS NO: 869886-67-9Molecular Formula: C21H23CI3N4O2Molecular Weight: 469.79Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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VX-809 may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF. Defects in the CFTR protein affect the transport of chloride and other ions across cells, and lead to the accumulation of thick, sticky mucus in the lungs of patients with CF. This mucus fosters chronic infection and inflammation, and results in irreversible lung damage.

prudect name : VX-809 may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF….

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Verteporfin (trade name Visudyne) is a benzoporphyrin derivative and is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Verteporfin is also used off-label for the treatment of central serous retinopathy.

prudect name : Verteporfin (trade name Visudyne) is a benzoporphyrin derivative and is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the…

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VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. IC50 value: Target: ERK

prudect name : VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. IC50 value: Target: ERKVX-11e Synonyms: CAS NO: 896720-20-0Molecular Formula: C24H20Cl2FN5O2Molecular Weight:…

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The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6, IL-12 and IFN¦Ã , all of which have been demonstrated to play important roles in autoimmune diseases such as rheumatoid arthritis (RA) and/or cardiovascular diseases. In an ex vivo blood assay primed with LPS, VX-702 dose-dependently inhibited the production of IL-6, IL-1¦Â and TNF¦Á (IC50 = 59, 122 and 99 ng/ml, respectively)

prudect name : The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6,…

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Voglibose for the improvement of postprandial hyperglycemia in diabetes mellitus

prudect name : Voglibose for the improvement of postprandial hyperglycemia in diabetes mellitusVoglibose Synonyms: 5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrolCAS NO: 83480-29-9Molecular Formula: C10H21NO7Molecular Weight: 267.13Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid

prudect name : Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acidVitamin H; Vitamin B7; D-Biotin Synonyms: CAS NO: 58-85-5 (22879-79-4)Molecular Formula: C10H16N2O3SMolecular Weight: 244.31Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com

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Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25 mg /kg/ day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.

prudect name : Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine…

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