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9-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-b]pyridin-5-one

June 21, 2017

prudect name : 9-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-b]pyridin-5-oneCID797718 Synonyms: CAS NO: 370586-05-3Molecular Formula: C12H11NO3Molecular Weight: 217.22Purity: 98% minSolubility: in DMSOStorage: -20oC RG1678 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509249

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Cediranib suppresses PDGF-AA with an IC50 of 0.04 ¦ÌM in MG63 cell lines. Cediranib has been shown to block Flt-1-associated kinase with an IC50 of 5 nM and VEGF-C and VEGF-D receptor Flt-4 with an IC50 of less than 3 nM. In addition, the IC50 values for inhibition of c-Kit and PDGFR-¦Â tyrosine kinase are 2 and 5 nM respectively. Furthermore, no inhibition of enzyme activity is observed when 10 ¦ÌM Cediranib is assayed with 100 ¦ÌM ATP against AMPK, Chk1 Akt/PKB and others. Micromolar concentrations of Cediranib are needed to prevent tumor cell proliferation in vitro.

prudect name : Cediranib suppresses PDGF-AA with an IC50 of 0.04 ¦ÌM in MG63 cell lines. Cediranib has been shown to block Flt-1-associated kinase with an IC50 of 5 nM…

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CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431

prudect name : CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with…

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Cyt387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. Cyt387 has significantly less activity against other kinases, including JAK3 (IC50=0.16 ¦ÌM). CYT387 inhibits growth of Ba/F3-JAK2V617F and human erythroleukemia (HEL) cells (IC50 = ~1.5 ¦ÌM) or Ba/F3-MPLW515L cells (IC50 = 0.2 ¦ÌM), but CYT387 has considerably less activity against BCR¨CABL harboring K562 cells (IC50 = 58 ¦ÌM). Cell lines harboring mutated JAK2 alleles (CHRF-288-11 or Ba/F3-TEL-JAK2) were inhibited more potently than the corresponding pair harboring mutated JAK3 alleles (CMK or Ba/F3-TEL-JAK3), and STAT-5 phosphorylation was inhibited in HEL cells with an IC50 of 0.4 ¦ÌM

prudect name : Cyt387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. Cyt387 has significantly less activity against other…

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CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1¨C101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases

prudect name : CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1¨C101) substrate. In addition, CP-466722 also shows the inhibitory activities…

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CAL-101(N-1) intermediates

prudect name : CAL-101(N-1) intermediatesCAL-101(N-1) Synonyms: CAS NO: 870281-86-0Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20oC Trodusquemine References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509181

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CAL-101 intermediates N-2

prudect name : CAL-101 intermediates N-2CAL-101 intermediates N-2 Synonyms: CAS NO: 870281-85-9Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20oC SYN-115 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509173

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Biological Activity of CYC116: CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. CYC116 has a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, it demonstrated antitumor activity in both solid tumors and hematological cancers.

prudect name : Biological Activity of CYC116: CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in…

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prudect name : Cefoxitin sodiumSynonyms: CAS NO: 33564-30-6Molecular Formula: C16H16N3NaO7S2Molecular Weight: 449.43Purity: 98% minSolubility: Storage:

prudect name : Cefoxitin sodium Synonyms: CAS NO: 33564-30-6Molecular Formula: C16H16N3NaO7S2Molecular Weight: 449.43Purity: 98% minSolubility: Storage: −20°C MK-8931 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509045

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prudect name : CTX 0294885;CTX0294885Synonyms: CTX-0294885CAS NO: 1439934-41-4Molecular Formula: C22H24ClN7OMolecular Weight: 437.17Purity: 98% minSolubility: in

prudect name : CTX 0294885;CTX0294885 Synonyms: CTX-0294885CAS NO: 1439934-41-4Molecular Formula: C22H24ClN7OMolecular Weight: 437.17Purity: 98% minSolubility: in DMSOStorage: -20oC ABT-267 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508996

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