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Enzastaurin induced marked dose-dependent growth inhibition in all MM cell lines investigated including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266.IC50 ranged from 0.6 to 1.6 ¦ÌM. Enzastaurin has a direct effect on human tumor cells, inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin treatment also suppresses the phosphorylation of GSK3ßser9, ribosomal protein S6S240/244, and AKTThr308.

June 21, 2017

prudect name : Enzastaurin induced marked dose-dependent growth inhibition in all MM cell lines investigated including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266.IC50 ranged from…

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Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B (EPO906) inhibits microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B (EPO906) possesses the same biological effects as paclitaxel both in vitro and in cultured cells. epothilone B suppressed microtubule dynamics in a concentration-dependent manner coincident with mitotic block. At 0.2 nm epothilone B, dynamics were not significantly altered. At 2 nm epothilone B (EPO906) (IC33), the mean growth and shortening rates were decreased by 38 and 27%, respectively. Dynamicity was decreased by 47%. At the IC50, 80% of the cells had nearly complete stabilization of microtubule dynamics, and no anaphase or telophase figures were observed.

prudect name : Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B (EPO906) inhibits microtubule function. Microtubules…

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Emtricitabine is a new nucleoside reverse transcriptase inhibitors.

prudect name : Emtricitabine is a new nucleoside reverse transcriptase inhibitors.Emtricitabine Synonyms: CAS NO: 143491-57-0Molecular Formula: C8H10FN3O3SMolecular Weight: 247.25Purity: ≥99%Solubility: Storage: −20°C 2 years GKT-137831 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18512763

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Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. Intermediary obtained in the synthesis of members of the Epothilone family, polyketide natural products that inhibit cancer cells via a mechanism similar to Paclitaxel. Epothilone D also found to be effective against Paclitaxel-resistant tumors. Epothilone D currently in Phase I of clinical testing.

prudect name : Epothilone D is a natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly…

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Sunitinib(CAS NO:557795-19-4)Intermediates

prudect name : Sunitinib(CAS NO:557795-19-4)Intermediatesethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Synonyms: CAS NO: 2199-59-9Molecular Formula: C10H13NO3Molecular Weight: 195.21Purity: ≥98%Solubility: Storage: −20°C 2 years Ilomastat References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18512675

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Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium glucose cotransporter- 2 (SGLT-2), which is found almost exclusively in the proximal tubules of nephronic components in the kidneys. SGLT-2 accounts for about 90 percent of glucose reabsorption into the blood. Blocking SGLT-2 causes blood glucose to be eliminated through the urine via the urethra. The Empagliflozin phase III clinical trial program will include about 14,500 patients.

prudect name : Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium…

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Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir hydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir hydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir hydrate is not active against HIV.

prudect name : Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that…

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EHop-016 is a novel potent and selective inhibitor of Rac GTPase; inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 uM.

prudect name : EHop-016 is a novel potent and selective inhibitor of Rac GTPase; inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 uM.EHOP-016 Synonyms: CAS NO: 1380432-32-5Molecular…

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prudect name : EtiprostonSynonyms: CAS NO: 59619-81-7Molecular Formula: C24H32O7Molecular Weight: 432.51Purity: 99%Solubility: Storage: -20¡æ

prudect name : Etiproston Synonyms: CAS NO: 59619-81-7Molecular Formula: C24H32O7Molecular Weight: 432.51Purity: 99%Solubility: Storage: -20¡æ GSK-2118436 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18512336

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prudect name : Eluxadoline;JNJ 27018966Synonyms: CAS NO: 864821-90-9Molecular Formula: C32H35N5O5Molecular Weight: 569.65Purity: 98% minSolubility: in

prudect name : Eluxadoline;JNJ 27018966 Synonyms: CAS NO: 864821-90-9Molecular Formula: C32H35N5O5Molecular Weight: 569.65Purity: 98% minSolubility: in DMSOStorage: -20oC PA 824 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18512329

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