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EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells.

June 21, 2017

prudect name : EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and…

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prudect name : Estradiol valerateSynonyms: CAS NO: 979-32-8Molecular Formula: C23H32O3Molecular Weight: 356.50Purity: 98% minSolubility: Storage:

prudect name : Estradiol valerate Synonyms: CAS NO: 979-32-8Molecular Formula: C23H32O3Molecular Weight: 356.50Purity: 98% minSolubility: Storage: −20°C GBR12909 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514405

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Epirubicin hydrochloride is the hydrochloride salt of the 4¡¯-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.

prudect name : Epirubicin hydrochloride is the hydrochloride salt of the 4¡¯-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA…

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EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). It was thought to block the release of deacetylated peptide and O-acetyl-ADP-ribose from the enzyme following the deacetylation process. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation. Blocking of SIRT1 by EX 527 also demonstrated that deacetylation of the important tumor suppressor protein p53 is mediated by SIRT1 as well.

prudect name : EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. It is Selective inhibitor of SIRT1 that…

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ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in ¦ÂIII-tubulin-overexpressing cell lines.

prudect name : ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in…

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prudect name : EtoposideSynonyms: CAS NO: 33419-42-0Molecular Formula: C29H32O13Molecular Weight: 588.56Purity: 98% minSolubility: in DMSOStorage:

prudect name : Etoposide Synonyms: CAS NO: 33419-42-0Molecular Formula: C29H32O13Molecular Weight: 588.56Purity: 98% minSolubility: in DMSOStorage: -20oC BI 10773 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514286

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prudect name : EpiestradiolSynonyms: CAS NO: 57-91-0Molecular Formula: C18H24O2Molecular Weight: 272.39Purity: 98% minSolubility: Storage: −20°C

prudect name : Epiestradiol Synonyms: CAS NO: 57-91-0Molecular Formula: C18H24O2Molecular Weight: 272.39Purity: 98% minSolubility: Storage: −20°C GW 786034 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514267

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prudect name : EstradiolSynonyms: CAS NO: 50-28-2Molecular Formula: C18H24O2Molecular Weight: 272.38Purity: 98% minSolubility: Storage: −20°C

prudect name : Estradiol Synonyms: CAS NO: 50-28-2Molecular Formula: C18H24O2Molecular Weight: 272.38Purity: 98% minSolubility: Storage: −20°C Ko143 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514191

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Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was approved by FDA in November 20, 2008.

prudect name : Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110),…

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ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFR¦Á

prudect name : ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and…

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