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Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT-1 activation inhibitor and a DNA synthesis inhibitor for RPMI 8226 cells with an IC50 of 1.54 ¦Ìg/mL.

June 21, 2017

prudect name : Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT-1 activation inhibitor and a DNA synthesis inhibitor for RPMI 8226 cells with an IC50 of 1.54 ¦Ìg/mL.Fludarabine Synonyms: CAS…

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prudect name : FUB 359 maleate saltSynonyms: CAS NO: 184025-19-2Molecular Formula: C16H18N2O2.C4H4O4Molecular Weight: 386.402Purity: 98%

prudect name : FUB 359 maleate salt Synonyms: CAS NO: 184025-19-2Molecular Formula: C16H18N2O2.C4H4O4Molecular Weight: 386.402Purity: 98% minSolubility: In DMSOStorage: -20°C R-roscovitine References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514730

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R788(FosD) is a selective Syk inhibitor with an IC50 of 41 nM. R788(FosD) has shown clinical activity in heavily pre-treated NHL and CLL patients, exhibits inhibitory activity against SYK but also inhibits a broad spectrum of other kinase targets. In addition to blocking Fc¦ÃR-mediated events, R788 also blocked BCR-mediated Ag presentation, thus broadly interrupting the humoral contributions to T cell-driven autoimmunity. Indeed, oral administration of R788(FosD) significantly delayed spontaneous diabetes onset in NOD mice and successfully delayed progression of early-established diabetes even when treatment was initiated after the development of glucose intolerance. At the DC level, R788 treatment was associated with reduced insulin-specific CD8 priming and decreased DC numbers. At the B cell level, R788(FosD) reduced total B cell numbers and total Ig concentrations. Interestingly, R788(FosD) increased the number of IL-10¨Cproducing B cells, thus inducing a tolerogenic B cell population with immunomodulatory activity. Taken together, Syk in APCs is an attractive target in T cell-mediated autoimmune diseases such as type 1 diabetes.

prudect name : R788(FosD) is a selective Syk inhibitor with an IC50 of 41 nM. R788(FosD) has shown clinical activity in heavily pre-treated NHL and CLL patients, exhibits inhibitory activity…

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FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent

prudect name : FK 3311 is a selective inhibitor of COX-2; antiinflammatory agentFK-3311;FK3311 Synonyms: CAS NO: 116686-15-8Molecular Formula: C15H13F2NO4SMolecular Weight: 341.33Purity: 98% minSolubility: in DMSOStorage: -20oC ICG001 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514655

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prudect name : FL118Synonyms: CAS NO: 151636-76-9Molecular Formula: Molecular Weight: Purity: 98% minSolubility: in DMSOStorage:

prudect name : FL118 Synonyms: CAS NO: 151636-76-9Molecular Formula: Molecular Weight: Purity: 98% minSolubility: in DMSOStorage: -20oC GW4064 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514579

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(2E,2¡¯E)-1,1¡¯-cyclohexylidenebis[3-(3,4-diMethoxyphenyl)-2-Propen-1-one

prudect name : (2E,2¡¯E)-1,1¡¯-cyclohexylidenebis[3-(3,4-diMethoxyphenyl)-2-Propen-1-oneFLLL32 Synonyms: CAS NO: 1226895-15-3Molecular Formula: Molecular Weight: Purity: 98% minSolubility: in DMSOStorage: -20oC SDZ-RAD References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514578

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Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

prudect name : Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.Fenretinide (4-HPR)…

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prudect name : FinasterideSynonyms: CAS NO: 98319-26-7Molecular Formula: C23H36N2O2Molecular Weight: 372.55Purity: 99% minSolubility: Storage: −20°C

prudect name : Finasteride Synonyms: CAS NO: 98319-26-7Molecular Formula: C23H36N2O2Molecular Weight: 372.55Purity: 99% minSolubility: Storage: −20°C RXDX-101 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514504

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Flavopiridol is a Phase 3 clinical trials in high anticancer drugs, can be used for the treatment of chronic lymphocytic leukemia.

prudect name : Flavopiridol is a Phase 3 clinical trials in high anticancer drugs, can be used for the treatment of chronic lymphocytic leukemia.Flavopiridol (Alvocidib) Synonyms: Flavopiridol (Alvocidib)CAS NO: 146426-40-6Molecular…

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prudect name : EtonogestrelSynonyms: CAS NO: 54048-10-1Molecular Formula: C22H28O2Molecular Weight: 324.46Purity: 99% minSolubility: Storage: −20°C

prudect name : Etonogestrel Synonyms: CAS NO: 54048-10-1Molecular Formula: C22H28O2Molecular Weight: 324.46Purity: 99% minSolubility: Storage: −20°C SCH-772984 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514489

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