IC50s for GSK1904529A in tumor cell lines ranged from 35 nmol/L to >30 umol/L.The tumor histologic types showing the greatest sensitivity to this compound were Ewing¡¯s sarcoma and multiple myeloma, where IC50s in three of five Ewing¡¯s sarcoma cell lines were <100 nmol/L and IC50s in five of eight multiple myeloma cell lines were <200 nmol/L .

 June 21, 2017

prudect name : IC50s for GSK1904529A in tumor cell lines ranged from 35 nmol/L to >30 umol/L.The tumor histologic types showing the greatest sensitivity to this compound were Ewing¡¯s sarcoma…

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GNF-2 is Bcr-abl inhibitor.

prudect name : GNF-2 is Bcr-abl inhibitor.GNF-2 Synonyms: CAS NO: 778270-11-4Molecular Formula: C18H13F3N4O2Molecular Weight: 374.32Purity: 98% minSolubility: In DMSOStorage: −20°C SYN115 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515569

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GSK690693 is an aminofurazan-derived£¬novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor. It is selective for the Akt isoforms(inhibits Akt kinases 1, 2, and 3 with IC50 values of 2, 13, and 9 nM respectively)versus the majority of kinases in other families; however, it does inhibit additional members of the AGC kinase family.

prudect name : GSK690693 is an aminofurazan-derived£¬novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor. It is selective for the Akt isoforms(inhibits Akt kinases 1, 2, and 3 with IC50 values of 2,…

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GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor, currently in Phase I/II trials.

prudect name : GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor, currently in Phase I/II trials.GSK2636771 Synonyms: CAS NO: 1372540-25-4Molecular Formula: C22H22F3N3O3Molecular Weight: 433.42Purity: 98% minSolubility: In DMSOStorage: -20°C…

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Gemfibrozil for hyperlipidemia. For serious or type ¢õ ¢ô hyperlipoproteinemia, coronary heart disease risk of large and diet control, weight loss and other treatment ineffective

prudect name : Gemfibrozil for hyperlipidemia. For serious or type ¢õ ¢ô hyperlipoproteinemia, coronary heart disease risk of large and diet control, weight loss and other treatment ineffectiveGemfibrozil Synonyms: CAS…

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GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

prudect name : GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the…

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GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line .For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879).

prudect name : GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified…

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E-7050 is hepatocyte growth factor receptors (HGFR).

prudect name : E-7050 is hepatocyte growth factor receptors (HGFR).Golvatinib (E7050) Synonyms: Golvatinib (E7050)CAS NO: 928037-13-2Molecular Formula: C33H37F2N7O4Molecular Weight: 633.69Purity: 98% minSolubility: In DMSOStorage: −20°C VX809 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515349

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FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ¦Â. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.

prudect name : FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern…

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5S rRNA modificator is a suitable electrophile for 2¡¯-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification.

prudect name : 5S rRNA modificator is a suitable electrophile for 2¡¯-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA…

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