GW9662 is a selective PPAR antagonist for PPAR¦Ã with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPAR¦Ã versus PPAR¦Á and PPAR¦Ä.

 June 21, 2017

prudect name : GW9662 is a selective PPAR antagonist for PPAR¦Ã with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPAR¦Ã versus PPAR¦Á…

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prudect name : Growth hormone releasing peptide;GHRP-6Synonyms: GHRP-6CAS NO: 87616-84-0Molecular Formula: C46H56N12O6Molecular Weight: 873.01Purity: 98%

prudect name : Growth hormone releasing peptide;GHRP-6 Synonyms: GHRP-6CAS NO: 87616-84-0Molecular Formula: C46H56N12O6Molecular Weight: 873.01Purity: 98% minSolubility: Storage: -20°C P-22077 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18516696

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Chemical Name:1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

prudect name : Chemical Name:1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochlorideGBR 12935 dihydrochloride Synonyms: CAS NO: 76778-22-8Molecular Formula: C28H34N2O.2(HCl)Molecular Weight: 487.50Purity: 98% minSolubility: In DMSOStorage: −20°C R7227 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18516691

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GW3965 recruits the steroid receptor coactivator 1 to human LXR¦Á with EC50 of 125 nM in a cell-free ligand-sensing assay. GW3965 shows a potent antagonistic activity against hLXR¦Á and hLXR¦Â in cell-based assays with EC50 of 190 nM and 30 nM, respectively. Besides, GW3965 also sows excellent selectivity over other nuclear receptors.

prudect name : GW3965 recruits the steroid receptor coactivator 1 to human LXR¦Á with EC50 of 125 nM in a cell-free ligand-sensing assay. GW3965 shows a potent antagonistic activity against…

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GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140¡À40 nM and 110¡À30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis.

prudect name : GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140¡À40 nM and 110¡À30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis.GSK-137831 Synonyms: CAS…

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GANT61 administration induced robust cytotoxicity in 5 of 6 cell lines and moderate cytotoxicity in the remaining 1 cell line. In comparison, the classical Smo inhibitor, cyclopamine, induced modest cytotoxicity. Further, GANT61 treatment abolished the clonogenicity of all six human colon carcinoma cell lines. GANT-61 inhibited cell viability, spheroid formation, and Gli-DNA binding and transcriptional activities, and induced apoptosis by activation of caspase-3 and cleavage of Poly-ADP ribose Polymerase (PARP). GANT-61 increased the expression of TRAIL-R1/DR4, TRAIL-R2/DR5 and Fas, and decreased expression of PDGFR¦Á and Bcl-2. GANT-61 also suppressed EMT by up-regulating E-cadherin and inhibiting N-cadherin and transcription factors Snail, Slug and Zeb1. GANT61 sensitivity positively correlated to GLI1 and negatively to MYCN expression in the neuroblastoma cell lines tested. GANT61 downregulated GLI1, c-MYC, MYCN and Cyclin D1 expression and induced apoptosis of neuroblastoma cells

prudect name : GANT61 administration induced robust cytotoxicity in 5 of 6 cell lines and moderate cytotoxicity in the remaining 1 cell line. In comparison, the classical Smo inhibitor, cyclopamine,…

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GDC-0810 (ARN-810) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.

prudect name : GDC-0810 (ARN-810) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.GDC-0810;ARN-810 Synonyms: CAS NO: 1365888-06-7Molecular Formula: C26H20ClFN2O2Molecular Weight: 446.90Purity: 98% minSolubility: In…

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GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.

prudect name : GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.GSK 2334470;GSK2334470 Synonyms: CAS NO: 1227911-45-6Molecular Formula: C25H34N8OMolecular Weight:…

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SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.

prudect name : SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.GSK 742457;SB 742457 Synonyms: CAS NO: 607742-69-8Molecular Formula:…

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Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrol­o[2,3-b]pyridin-3-yl-benzoic acid

prudect name : Chemical Name: 2-Cyclopentyl-4-(5-phenyl-1H-pyrrol­o[2,3-b]pyridin-3-yl-benzoic acidGSK 650394 Synonyms: CAS NO: 890842-28-1Molecular Formula: C25H22N2O2Molecular Weight: 382.45Purity: 98% minSolubility: In DMSOStorage: -20°C GLPG 0634 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18516394

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