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Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.

June 21, 2017

prudect name : Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.Icilin(AG 3-5) Synonyms: CAS NO: 36945-98-9Molecular Formula: C16H13N3O4Molecular Weight: 311.29Purity: 98% minSolubility: in DMSOStorage: -20oC FK-866 References PubMed…

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IRAK-1/4 Inhibitor; anti-inflammatory agent.

prudect name : IRAK-1/4 Inhibitor; anti-inflammatory agent.IRAK-1-4 Inhibitor I Synonyms: CAS NO: 509093-47-4Molecular Formula: C20H21N5O4 Molecular Weight: 395.41Purity: 98% minSolubility: In DMSOStorage: -20°C CX4945 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519291

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prudect name : IloprostSynonyms: CAS NO: 78919-13-8Molecular Formula: C22H32O4Molecular Weight: 360.49Purity: 99%Solubility: Storage: -20¡æ

prudect name : Iloprost Synonyms: CAS NO: 78919-13-8Molecular Formula: C22H32O4Molecular Weight: 360.49Purity: 99%Solubility: Storage: -20¡æ ABT 627 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519281

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Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM. Idasanutlin inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53.

prudect name : Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM. Idasanutlin inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53…

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IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile.

prudect name : IPI-145 is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic…

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Idarubicin adaptation in adult acute non-lymphocytic leukemia the induction of remission, relapse, remission induction of refractory patients

prudect name : Idarubicin adaptation in adult acute non-lymphocytic leukemia the induction of remission, relapse, remission induction of refractory patientsIdarubicin Synonyms: CAS NO: 58957-92-9Molecular Formula: C26H27NO9Molecular Weight: 497.49Purity: 98% minSolubility:…

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prudect name : IdoxifeneSynonyms: CAS NO: IdoxifeneMolecular Formula: C28H30INOMolecular Weight: 523.45Purity: 98% minSolubility: In DMSOStorage:

prudect name : Idoxifene Synonyms: CAS NO: IdoxifeneMolecular Formula: C28H30INOMolecular Weight: 523.45Purity: 98% minSolubility: In DMSOStorage: -20°C AZD 0530 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519247

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MK-677; 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4¡¯-piperidin]-1¡¯-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate

prudect name : MK-677; 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4¡¯-piperidin]-1¡¯-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonateIbutamoren mesylate MK-677 Synonyms: CAS NO: 624.77Molecular Formula: C27H36N4O5S.CH4O3SMolecular Weight: 624.77Purity: 98% minSolubility: In DMSOStorage: -20°C SU 5416 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519244

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Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).

prudect name : Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM,…

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HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but does not appear to directly inhibit PLK1. Instead, it alters its spatial distribution, resulting in cell cycle arrest at the G2¨CM phase, with destruction of the spindle polar bodies followed by DNA fragmentation. Drug-resistant cell lines showed low crossresistance to HMN-176. In human tumor xenografts, there was a broad spectrum of antitumor activity. The antitumor activity of HMN-214 was equal or superior to that of clinically available agents, including cisplatin, doxorubicin, vincristine, and tegafur-uracil .

prudect name : HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but…

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