VD/VDR-vd-vdr.com

N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide sodium salt; LY 573636Na

June 21, 2017

prudect name : N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide sodium salt; LY 573636NaTasisulam sodium LY-573636 Synonyms: CAS NO: 519055-63-1Molecular Formula: C11H6BrCl2NO3S2.NaMolecular Weight: 438.09Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. After binding of TAK-901 to Aurora B, it inhibits the activity of Aurora B, which may result in a reduction in the proliferation of tumor cells that overexpress Aurora B. TAK-901 is originally developed by Millennium Pharmaceuticals, Inc.. And TAK-901 is been performed phase I clinical trials for the treatment of advanced solid tumors and lymphoma.

prudect name : TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B is a positive regulator of mitosis that functions in the…

📌

0💬 read more

Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.

prudect name : Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53…

📌

0💬 read more

TAK-700 is a type of selective effect of oral non-steroidal androgen synthesis inhibitors. Pre-clinical results show that it can selectively lock and inhibit the testes and adrenal glands among the 17, 20 carbon chain cleavage enzyme

prudect name : TAK-700 is a type of selective effect of oral non-steroidal androgen synthesis inhibitors. Pre-clinical results show that it can selectively lock and inhibit the testes and adrenal…

📌

0💬 read more

Tigecycline is a glycylcycline antibiotic. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and acinetobacter baumanii.

prudect name : Tigecycline is a glycylcycline antibiotic. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and acinetobacter baumanii.Tigecycline Synonyms:…

📌

0💬 read more

TAK-285 is a novel dual erbB protein kinase inhibitor that specifically targets human epidermal growth factor receptor (EGFR) and HER2. Methods: TAK-285 is currently being developed by Takeda. TAK-285 was found to be well tolerate in Phase I trials. Absorption of TAK-285 was rapid after oral dosing, and plasma exposure at steady-state increased in a dose-proportional fashion for doses ranging from 50 to 300 mg b.i.d. A partial response was observed for one patient with parotid cancer who received 300 mg b.i.d. The toxicity profile and PK properties of oral TAK-285 warrant further evaluation.

prudect name : TAK-285 is a novel dual erbB protein kinase inhibitor that specifically targets human epidermal growth factor receptor (EGFR) and HER2. Methods: TAK-285 is currently being developed by…

📌

0💬 read more

prudect name : Torin 1Synonyms: Torin 1CAS NO: 1222998-36-8Molecular Formula: C35H28F3N5O2Molecular Weight: 607.62Purity: 98% minSolubility:

prudect name : Torin 1 Synonyms: Torin 1CAS NO: 1222998-36-8Molecular Formula: C35H28F3N5O2Molecular Weight: 607.62Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

Tofacitinib inhibits IL-2-mediated human T cell blast proliferation and IL-15-induced CD69 expression with IC50 of 11 nM and 48 nM, respectively. Tofacitinib prevents mixed lymphocyte reaction with IC50 of 87 nM. Tofacitinib treatment of murine factor-dependent cell Patersen¨Cerythropoietin receptor (FDCP-EpoR) cells harboring human wild-type or V617F JAK2 leads to prevention of cell proliferation with IC50 of 2.1 µM and 0.25 µM, respectively. Tofacitinib inhibits interleukin-6-induced phosphorylation of STAT1 and STAT3 with IC50 of 23 nM and 77 nM, respectively. Moreover, Tofacitinib generates a significant pro-apoptotic effect on murine FDCP-EpoR cells carrying JAK2VV617F, whereas a lesser effect was observed for cells carrying wild-type JAK2. This activity is coupled with the inhibition of phosphorylation of the key JAK2V617F-dependent downstream signaling effectors signal transducer and activator of transcription (STAT)3, STAT5, and v-akt murine thymoma viral oncogene homolog (AKT).

prudect name : Tofacitinib inhibits IL-2-mediated human T cell blast proliferation and IL-15-induced CD69 expression with IC50 of 11 nM and 48 nM, respectively. Tofacitinib prevents mixed lymphocyte reaction with…

📌

0💬 read more

prudect name : THIACETAZONESynonyms: CAS NO: 104-06-3Molecular Formula: C10H12N4OSMolecular Weight: 236.29Purity: 98% minSolubility: In DMSOStorage:

prudect name : THIACETAZONE Synonyms: CAS NO: 104-06-3Molecular Formula: C10H12N4OSMolecular Weight: 236.29Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

prudect name : Terbinafine hydrochlorideSynonyms: N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amineCAS NO: 91161-71-6Molecular Formula: C21H25N.HClMolecular Weight: 327.90Purity: ≥99%Solubility: Storage: −20°C

prudect name : Terbinafine hydrochloride Synonyms: N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amineCAS NO: 91161-71-6Molecular Formula: C21H25N.HClMolecular Weight: 327.90Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

📌

0💬 read more