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prudect name : Isopropyl unoprostoneSynonyms: Isopropyl unoprostoneCAS NO: 120373-24-2Molecular Formula: C25H44O5Molecular Weight: 424.61Purity: 98% minSolubility:

June 21, 2017

prudect name : Isopropyl unoprostone Synonyms: Isopropyl unoprostoneCAS NO: 120373-24-2Molecular Formula: C25H44O5Molecular Weight: 424.61Purity: 98% minSolubility: Storage: −20°C GBR 12909 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18520039

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Ixabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It is produced by Sorangium cellulosum. On October 16, 2007, the U.S. Food and Drug Administration approved ixabepilone for the treatment of aggressive metastatic or locally advanced breast cancer no longer responding to currently available chemotherapies. In November 2008, the EMEA has refused a marketing authorisation for Ixabepilone. Ixabepilone is administered through injection, and is marketed under the trade name Ixempra.

prudect name : Ixabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It is produced by Sorangium…

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MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).

prudect name : MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of…

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Ibudilast for mild to moderate bronchial asthma.

prudect name : Ibudilast for mild to moderate bronchial asthma.Ibudilast Synonyms: CAS NO: 50847-11-5Molecular Formula: C14H18N2OMolecular Weight: 230.31Purity: ≥99%Solubility: Storage: −20°C 2 years GW-786034 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519955

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ICG-001 is a selective Wnt/¦Â-catenin signalling inhibitor with an IC50 of 3¦ÌM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 rescues defects in neuronal differentiation and reverse pulmonary fibrosis. ICG-001 also suppressed the interaction between CREB and ¦Ã-catenin.

prudect name : ICG-001 is a selective Wnt/¦Â-catenin signalling inhibitor with an IC50 of 3¦ÌM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding…

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IOWH032 is a CFTR inhibitor. Diarrhea, a disease of poverty and poor sanitation, kills an estimated two million children each year. Oral rehydration therapy is a very simple and inexpensive treatment that has significantly reduced mortality from secretory diarrhea caused by rotavirus, cholera and enterotoxigenic Escherichia coli. The efficacy and adoption of oral rehydration therapy would be enhanced by a drug that reduces fluid loss associated with these diseases and alleviates disease symptoms. Secretion and absorption by the intestine offer a number of potential drug targets to reduce fluid loss. Among these, the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the most attractive because it is the primary driver of secretion in cases of diarrhea caused by enterotoxigenic bacteria. CFTR can be inhibited by both natural products and synthetic small molecules. iOWH032 is a synthetic CFTR inhibitor that has recently entered clinical trials for this indication.

prudect name : IOWH032 is a CFTR inhibitor. Diarrhea, a disease of poverty and poor sanitation, kills an estimated two million children each year. Oral rehydration therapy is a very…

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Biological Activity: Potent inhibitor of hypoxia inducible factor 1¦Á prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

prudect name : Biological Activity: Potent inhibitor of hypoxia inducible factor 1¦Á prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1)…

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ISX-9 is a small molecule inducer of adult neural stem cell differentiation.

prudect name : ISX-9 is a small molecule inducer of adult neural stem cell differentiation.ISX-9 Synonyms: CAS NO: 832115-62-5Molecular Formula: C11H10N2O2SMolecular Weight: 234.27Purity: 98% minSolubility: In DMSOStorage: -20 oC GDC0941…

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ITD-1 is an inducer of TGF_beta_ type II receptor degradation-1, is a potent and highly selective TGF_beta_ pathway inhibitor (IC50 = 0.85 _mu_M).

prudect name : ITD-1 is an inducer of TGF_beta_ type II receptor degradation-1, is a potent and highly selective TGF_beta_ pathway inhibitor (IC50 = 0.85 _mu_M).ITD 1;ITD-1 Synonyms: CAS NO:…

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IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/¦Â-catenin in general and displays no effect against Wnt-stimulated cellular responses.IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and ¦Â-catenin accumulation.

prudect name : IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/¦Â-catenin in general and…

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