T-1095 is a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). T-1095 may be a useful antidiabetic drug. Long-term treatment with T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki Rats. Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and haemoglobin A(1C) levels, and improved glucose intolerance in db/db mice. The age-related decrease in plasma insulin levels was markedly inhibited and there was a 2.5 fold increase of insulin content in the pancreas of T-1095-treated db/db mice. T-1095 improved the metabolic abnormalities and inhibit the development of diabetic complications in db/db mice. Thus, T-1095 can be used for therapy of type 2 diabetic patients.

 June 21, 2017

prudect name : T-1095 is a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). T-1095 may be a useful antidiabetic drug. Long-term treatment with T-1095 causes sustained improvement in hyperglycemia…

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Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2 (IC50 = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo.

prudect name : Inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185erbB-2…

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Thiazovivin dramatically improves the survival of hESCs upon trypsinization1. In combination with ALK5 (TGF¦Â receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, Thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method.

prudect name : Thiazovivin dramatically improves the survival of hESCs upon trypsinization1. In combination with ALK5 (TGF¦Â receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901, Thiazovivin promotes the transformation of fibroblasts…

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9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate

prudect name : 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarateTenofovir disoproxil fumarate Synonyms: CAS NO: 202138-50-9Molecular Formula: C19H30N5O10P.C4H4O4Molecular Weight: 635.51Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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Biological Activity of TAME: TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 ¦ÌM. TAME binds to the APC and prevents its activation by Cdc20 and Cdh1. TAME also inhibited cyclin degradation in interphase extract activated by exogenous Cdh1, but had no effect on SCF-dependent proteolysis of ¦Â-catenin- luciferase. TAME arrested the extract in mitosis, with stable cyclin B1 and phosphorylated Cdc27. Another APC substrate, cyclinA2,was also stabilized by TAME in Xenopus extract. Besides, TAME is a potent non-airway smooth muscle constrictor with an IC50 of 43 ¦ÌM in vitro. Under in vitro conditions N-alpha-tosyl L-arginine methyl ester (TAME) induced a concentration dependent contractile response on ileal strips.

prudect name : Biological Activity of TAME: TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 ¦ÌM. TAME binds to the APC and prevents its…

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T0901317 is a potent and selective agonist for both LXR¦Á and LXR¦Â, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol. 1 Repa, J.J., Turley, S.D., Lobaccaro, J.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 1524-1529 (2000).

prudect name : T0901317 is a potent and selective agonist for both LXR¦Á and LXR¦Â, with an EC50 of about 50 nM.1 T0901317 acting through LXR and in concert with…

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Telaprevir is an investigational oral hepatitis C virus (HCV) protease inhibitor with an IC50 of < 0.2 µM. It is an experimental treatment for hepatitis C. Specifically, it inhibits the hepatitis C virus NS3.4A serine protease.

prudect name : Telaprevir is an investigational oral hepatitis C virus (HCV) protease inhibitor with an IC50 of < 0.2 µM. It is an experimental treatment for hepatitis C. Specifically,...

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prudect name : TasquinimodSynonyms: CAS NO: 254964-60-8Molecular Formula: C20H17F3N2O4Molecular Weight: 406.36Purity: 98% minSolubility: in DMSOStorage:

prudect name : Tasquinimod Synonyms: CAS NO: 254964-60-8Molecular Formula: C20H17F3N2O4Molecular Weight: 406.36Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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prudect name : Tafluprost acidSynonyms: AFP 172CAS NO: 209860-88-8Molecular Formula: C22H28F2O5Molecular Weight: 410.45Purity: 98% minSolubility:

prudect name : Tafluprost acid Synonyms: AFP 172CAS NO: 209860-88-8Molecular Formula: C22H28F2O5Molecular Weight: 410.45Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com

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prudect name : tert-butyl 4-((5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylateSynonyms: CAS NO: 1001201-61-1Molecular Formula: C17H26N4O3Molecular Weight: 334.20Purity: 98% minSolubility: Storage:

prudect name : tert-butyl 4-((5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate Synonyms: CAS NO: 1001201-61-1Molecular Formula: C17H26N4O3Molecular Weight: 334.20Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com

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