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dacaterol is a novel, once-daily (o.d.) inhaled, long-acting ¦Â2-agonist in development for chronic obstructive pulmonary disease (COPD).

June 21, 2017

prudect name : dacaterol is a novel, once-daily (o.d.) inhaled, long-acting ¦Â2-agonist in development for chronic obstructive pulmonary disease (COPD).Indacaterol Synonyms: CAS NO: 312753-06-3Molecular Formula: C24H28N2O3Molecular Weight: 392.49Purity: 98% minSolubility:…

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prudect name : Intermediate of MK-8245Synonyms: CAS NO: 916889-25-3Molecular Formula: Molecular Weight: Purity: 98% minSolubility:

prudect name : Intermediate of MK-8245 Synonyms: CAS NO: 916889-25-3Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: −20°C ACP 103 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18520499

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Biological Activity£º Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 ¦ÌM). Stimulates proteasome activity and substrate degradation.

prudect name : Biological Activity£º Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 ¦ÌM). Stimulates proteasome activity and substrate degradation.IU1 Synonyms: CAS...

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INCB018424 is an orally bioavailable JAK inhibitor with potential antineoplastic and immunomodulating activities. INCB018424, a characterized JAK1/JAK2 inhibitor (IC50 values for JAK1, JAK2 and JAK3 are 3, 5 and 332 nM, respectively), has reached clinical trials for oncology indications, rheumatoid arthritis, and psoriasis. This compound is worth noting due to its opposite potency profile in the inhibition of the JAK enzymes when compared to CP-690,550.

prudect name : INCB018424 is an orally bioavailable JAK inhibitor with potential antineoplastic and immunomodulating activities. INCB018424, a characterized JAK1/JAK2 inhibitor (IC50 values for JAK1, JAK2 and JAK3 are 3,…

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MLN2238 inhibits the chymotrypsin-like proteolytic (¦Â5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (¦Â1) and trypsin-like (¦Â2) proteolytic sites, with IC50 of 31 and 3500 nM

prudect name : MLN2238 inhibits the chymotrypsin-like proteolytic (¦Â5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits…

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ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites. After treatment with 25¦ÌM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by ¦Â-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells. ICG-001, can phenotypically rescue normal nerve growth factor (NGF) -induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/¦Â-catenin signaling pathway on neurite outgrowth and neuronal differentiation. A recent study demonstrates that 5¦ÌM ICG-001 inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells.

prudect name : ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites. After treatment with 25¦ÌM of ICG-001 for 8 hours, SW480 cell reduces…

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INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.

prudect name : INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of…

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Ivermectin is a new broad-spectrum, high efficiency, low toxicity and antiparasitic antibiotics

prudect name : Ivermectin is a new broad-spectrum, high efficiency, low toxicity and antiparasitic antibioticsIvermectin Synonyms: CAS NO: 70288-86-7Molecular Formula: C48H74O14Molecular Weight: 875.11Purity: ≥99%Solubility: Storage: −20°C 2 years Lucitanib References…

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INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value <100 nM. IC50 Value: <100 nM [1] Target: Indoleamine-2,3-dioxygenase IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.

prudect name : INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value

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IKK-16 (IKK Inhibitor VII) is a selective I¦ÊB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.

prudect name : IKK-16 (IKK Inhibitor VII) is a selective I¦ÊB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM…

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