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Chemical Name: 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride

June 21, 2017

prudect name : Chemical Name: 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochlorideJNJ 5207852 dihydrochloride Synonyms: CAS NO: 398473-34-2Molecular Formula: C20H32N2OMolecular Weight: 316.5Purity: 98% minSolubility: DMSOStorage: -20¡æ GS 4997 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521013

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JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and 50 nmol/L, respectively. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo.

prudect name : JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and…

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JSH-23 is an inhibitor of NF-¦ÊB transcriptional activity with IC50 of 7.1 ¦ÌM in RAW 264.7 cell line.

prudect name : JSH-23 is an inhibitor of NF-¦ÊB transcriptional activity with IC50 of 7.1 ¦ÌM in RAW 264.7 cell line.JSH 23 Synonyms: CAS NO: 749886-87-1Molecular Formula: C16H20N2Molecular Weight: 240.34Purity:…

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JNJ-7706621 also shows some inhibition to VEGF-R2, FGF-R2, and GSK3¦Â, with IC50 of 154¨C254 nM. JNJ-7706621 shows inhibitory effect on a panel of human cancer cell types, including HeLa, HCT-116, SK-OV-3, PC3, DU145, A375, MDA-MB-231, MES-SA, and MES-SA/Dx5, with IC50 of 112¨C514 nM, independent of p53, retinoblastoma, or P-glycoprotein status. JNJ-7706621 is several-fold less potent at inhibiting growth of normal cell types, including MRC-5, HASMC, HUVEC, and HMVEC, with IC50 of 3.67¨C5.42 ¦ÌM. In HeLa or U937 cells, JNJ-7706621 (0.5¨C3 ¦ÌM) delays exit from G1, arrests cells in G2-M, induces endoreduplication, activates apoptosis, and reduces colony formation. In a HeLa cell line, incremental treatment with increasing concentrations of JNJ-7706621 leads to a 16-fold resistance, which may be mediated by ABCG2

prudect name : JNJ-7706621 also shows some inhibition to VEGF-R2, FGF-R2, and GSK3¦Â, with IC50 of 154¨C254 nM. JNJ-7706621 shows inhibitory effect on a panel of human cancer cell types,…

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JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively.

prudect name : JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C,…

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JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2 autophosphorylation in COS cells or SRC in cell-free kinase assays. JAK2 Inhibitor V, Z3 suppresses the JAK2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.

prudect name : JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect…

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J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).

prudect name : J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).J-147;J147;J 147 Synonyms: CAS NO:…

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JTC-801 displays about 12.5-, 129-, and 1055-fold selectivity for ORL1 receptor (Ki = 8.2 nM) over ¦Ì-, ¦Ê-, and ¦Ä-opioid receptors, respectively. JTC-801 does not inhibit forskolin-stimulated cyclic AMP accumulation in human ORL1 receptor-expressing HeLa cells, but it prevents nociceptin-induced inhibition of cyclic AMP accumulation, indicating that JTC-801 possesses full antagonistic activity. [2] In rat cerebrocortical membrane, JTC-801 inhibits ORL1 receptor with IC50 of 472 nM and ¦Ì-receptor with IC50 of 1831 nM. JTC-801 completely antagonizes the suppression of nociceptin on forskolin-induced accumulation of cyclic AMP with IC50 of 2.58 ¦ÌM in HeLa cells expressing ORL1 receptor.

prudect name : JTC-801 displays about 12.5-, 129-, and 1055-fold selectivity for ORL1 receptor (Ki = 8.2 nM) over ¦Ì-, ¦Ê-, and ¦Ä-opioid receptors, respectively. JTC-801 does not inhibit forskolin-stimulated…

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JNJ31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.

prudect name : JNJ31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.JNJ-31020028 Synonyms: CAS NO: 1094873-14-9Molecular…

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Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

prudect name : Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence…

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