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(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride

June 21, 2017

prudect name : (+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochlorideTemocapril hydrochloride Synonyms: CAS NO: 110221-44-8Molecular Formula: C23H28N2O5S2.HClMolecular Weight: 513.07Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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The FMS-like tyrosine kinase 3 (FLT3) protein is a receptor tyrosine kinase that is expressed at high levels in 70-100% of cases of AML(Acute myeloid leukemia) and has been identified as potential target for molecular therapy. Internal tandem duplications (ITD) of the juxtamembrane domain in FLT3 occur regularly in de novo AML, resulting in constitutive activation of FLT3 tyrosine kinase activity. [1]In cell-based assays tandutinib inhibited FLT3 ,PDGFR, and KIT with IC50 values of 95-122 ng/mL, but had no significant effect against a broad range of other kinases. In Ba/F3 cells expressing various FLT3-ITD mutants, tandutinib inhibited IL-3-independent growth and FLT3-ITD auto-phosphorylation with IC50 values of 6-17 ng/ml. Tandutinib also inhibited in vitro proliferation of human leukemia cell lines containing FLT3-ITD mutations with IC50 values of approximately 6 ng/mL. [2]Tandutinib has a very limited spectrum of activity outside the type III receptor kinase family. Evaluation of tandutinib in rats, dogs, and monkeys showed it to be orally bioavailable, metabolically stable.Phase I clinical results with tandutinib (MLN518) in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics.

prudect name : The FMS-like tyrosine kinase 3 (FLT3) protein is a receptor tyrosine kinase that is expressed at high levels in 70-100% of cases of AML(Acute myeloid leukemia) and…

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TENOFOVIR(PMPA) is a drug used to treat human immunodeficiency virus (HIV) infection. Tenofovir is an antiviral drug called a nucleotide reverse transcriptase inhibitor. Tenofovir may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood. Tenofovir is used in combination with other drugs to treat the HIV virus. Tenofovir will not cure or prevent HIV infection or AIDS.

prudect name : TENOFOVIR(PMPA) is a drug used to treat human immunodeficiency virus (HIV) infection. Tenofovir is an antiviral drug called a nucleotide reverse transcriptase inhibitor. Tenofovir may reduce the…

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Teicoplanin is a new parenteral administration of glycopeptide antibiotics, has a strong bactericidal activity.

prudect name : Teicoplanin is a new parenteral administration of glycopeptide antibiotics, has a strong bactericidal activity.Teicoplanin Synonyms: CAS NO: 61036-62-2Molecular Formula: C78H77Cl2N8O32RMolecular Weight: 1709.39Purity: 95%Solubility: Storage: −20°C 2 years…

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tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane

prudect name : tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilanetert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane Synonyms: CAS NO: 1234708-04-3Molecular Formula: C44H45FO4SiMolecular Weight: 684.30700Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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AV-951(Tivozanib) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.AV-951(Tivozanib) has potential antiangiogenic and antineoplastic activities. AV-951(Tivozanib) inhibits c-Kit and PDGFR at 10-times higher concentrations. AV-951(Tivozanib) is a novel oral quinoline urea derivative. Preclinical data indicate that AV-951 blocks the proliferation and migration of endothelial cells in vitro, and suppresses angiogenesis and growth of human tumor xenografts in vivo. Tivozanib has been shown to be safe and orally bioavailable when given to cancer patients. AV-951(Tivozanib) is under early clinical investigation for the treatment of renal cell carcinoma and non-small cell lung carcinoma, as well as in combination with other chemotherapies in breast, colorectal, and other gastrointestinal cancer patients.

prudect name : AV-951(Tivozanib) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.AV-951(Tivozanib) has potential…

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TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.TAK-063 has potent inhibitory activity (IC50 = 0.30 nM), excellent selectivity (>15000-fold selectivity over other PDEs), and favorable pharmacokinetics, including high brain penetration, in mice. Oral administration of TAK-063 to mice elevated striatal 3¡¯,5¡¯-cyclic adenosine monophosphate (cAMP) and 3¡¯,5¡¯-cyclic guanosine monophosphate (cGMP) levels at 0.3 mg/kg and showed potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg

prudect name : TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.TAK-063 has potent inhibitory activity (IC50 =…

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3,4-Thiazolidinedicarboxylic acid 3-ethyl ester

prudect name : 3,4-Thiazolidinedicarboxylic acid 3-ethyl esterTelmesteine Synonyms: CAS NO: 122946-43-4Molecular Formula: C7H11NO4SMolecular Weight: 205.23Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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TAS-103(BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).

prudect name : TAS-103(BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topoII).TAS-103(BMS-247615) Synonyms: CAS NO: 174634-08-3 174634-09-4(dihydrochloride£©Molecular Formula: C20H19N3O2Molecular Weight: 333.38Purity: 98% minSolubility: in DMSOStorage: -20oC web site:…

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TRV 130 Hcl is a novel ¦Ì-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less ¦Â-arrestin recruitment and receptor internalization.

prudect name : TRV 130 Hcl is a novel ¦Ì-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far…

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