KW-2478 inhibits the binding of bRD to Hsp90¦Á with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1R¦Âand c-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf and cyclin D1 genes by mainly suppressing the function of Cdk9.

 June 21, 2017

prudect name : KW-2478 inhibits the binding of bRD to Hsp90¦Á with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1R¦Âand c-Raf-1. KW-2478 reduces the…

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KU-55933 is a potent ATM inhibitor with an IC50 and a Ki of 13 and 2.2 nM, respectively. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3-kinase¨Clike kinases. Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Derivatives of this molecule may serve as novel radio- and chemosensitizors in clinical settings.

prudect name : KU-55933 is a potent ATM inhibitor with an IC50 and a Ki of 13 and 2.2 nM, respectively. KU-55933 shows specificity with respect to inhibition of other…

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(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N¡¯-(pyrazin-2-yl)acrylohydrazide

prudect name : (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N¡¯-(pyrazin-2-yl)acrylohydrazideKPT-330, (E)-RN Synonyms: CAS NO: 1421923-86-5Molecular Formula: Molecular Weight: 443.09Purity: 98% minSolubility: in DMSOStorage: -20oC CUDC 427 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521900

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KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study.

prudect name : KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study.KC7F2 Synonyms: CAS NO: 927822-86-4Molecular Formula: C16H16Cl4N2O4S4Molecular Weight: 570.38Purity:…

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N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide

prudect name : N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamideKobe0065 Synonyms: CAS NO: 436133-68-5Molecular Formula: C15H11ClF3N5O4SMolecular Weight: 449.79Purity: 98% minSolubility: in DMSOStorage: -20oC PR-171 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521848

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kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).

prudect name : kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).kb-NB77-78 Synonyms: CAS NO: 1350622-33-1Molecular Formula: C18H25NO3SiMolecular Weight: 331.48Purity:…

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KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.

prudect name : KY02111 is a small molecule which can promote differentiation of hPSCs to cardiomyocytes.KY02111 Synonyms: CAS NO: 1118807-13-8Molecular Formula: C18H17ClN2O3SMolecular Weight: 376.86Purity: 98% minSolubility: In DMSOStorage: -20 oC…

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KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.

prudect name : KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.KX1-004 Synonyms: CAS NO: 518058-84-9Molecular Formula: C16H13FN2O2Molecular Weight: 284.29Purity: 98% minSolubility: in…

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Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuran­yl)-1H-imidazole

prudect name : Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuran­yl)-1H-imidazoleKU14R Synonyms: CAS NO: 189224-48-4Molecular Formula: C13H14N2OMolecular Weight: 214.27Purity: 98% minSolubility: In DMSOStorage: -20°C GLPG-0634 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521620

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prudect name : Kanamycin sulfateSynonyms: CAS NO: 25389-94-0Molecular Formula: C18H36N4O11.H2SO4;C18H38N4O15SMolecular Weight: 582.57Purity: 98% minSolubility: Storage:

prudect name : Kanamycin sulfate Synonyms: CAS NO: 25389-94-0Molecular Formula: C18H36N4O11.H2SO4;C18H38N4O15SMolecular Weight: 582.57Purity: 98% minSolubility: Storage: -20oC CK 2017357 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521568

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