UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK 383367 inhibited deposition of insoluble collagen by 76 ¡À 2% at 10 ¦ÌM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 ¦Ìg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK 383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 ¦ÌM for them).

 June 21, 2017

prudect name : UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK 383367 inhibited deposition of insoluble collagen…

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prudect name : UramustineSynonyms: CAS NO: 66-75-1Molecular Formula: C8H11Cl2N3O2Molecular Weight: 252.0998Purity: 99%Solubility: Storage: −20°C

prudect name : Uramustine Synonyms: CAS NO: 66-75-1Molecular Formula: C8H11Cl2N3O2Molecular Weight: 252.0998Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one

prudect name : 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-oneURB 754 Synonyms: CAS NO: 86672-58-4Molecular Formula: C16H14N2O2Molecular Weight: 266.29Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.

prudect name : URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2,…

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URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 produced measurable antidepressant and analgesic effects by increasing endocannabinoids. URB597 shows both anti-nociceptive and anxiolytic effects in vivo but not evokes other symptoms associated with cannabinoid-like compounds. Hence, URB597 may provide a new strategy for the treatment of pain and anxiety

prudect name : URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is…

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prudect name : unoprostoneSynonyms: CAS NO: 120373-36-6Molecular Formula: C22H38O5Molecular Weight: 382.53Purity: 99% minSolubility: Storage: −20°C

prudect name : unoprostone Synonyms: CAS NO: 120373-36-6Molecular Formula: C22H38O5Molecular Weight: 382.53Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com

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UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.

prudect name : UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.UK-371804 Synonyms: CAS NO: 256477-09-5Molecular Formula: C₁₄H₁₆ClN₅O₄SMolecular Weight: 256477-09-5Purity: 98% minSolubility: DMSOStorage: -20°C web…

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prudect name : UbenimexSynonyms: CAS NO: 58970-76-6Molecular Formula: C16H24N2O4Molecular Weight: 308.38Purity: 99%Solubility: Storage: −20°C 2

prudect name : Ubenimex Synonyms: CAS NO: 58970-76-6Molecular Formula: C16H24N2O4Molecular Weight: 308.38Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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U0126 is an inhibitor of both MEK1(IC50 of 72 nM) and MEK2(IC50 of 58 nM). U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2.

prudect name : U0126 is an inhibitor of both MEK1(IC50 of 72 nM) and MEK2(IC50 of 58 nM). U0126 is a highly selective inhibitor of both MEK1 and MEK2, a…

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prudect name : Thymosin alpha 1Synonyms: CAS NO: 62304-98-7 (69440-99-9)Molecular Formula: C129H215N33O55Molecular Weight: 3108.30Purity: 98%

prudect name : Thymosin alpha 1 Synonyms: CAS NO: 62304-98-7 (69440-99-9)Molecular Formula: C129H215N33O55Molecular Weight: 3108.30Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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