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LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 ¦ÌM and 3.87 ¦ÌM in BxPc-3 and Panc-1 cells.

June 21, 2017

prudect name : LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 ¦ÌM and 3.87 ¦ÌM in BxPc-3 and Panc-1 cells.LB-100 Synonyms: CAS NO: 1026680-07-8Molecular Formula: C13H20N2O4Molecular Weight:…

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LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively. IC50 value: <5 nM/8 nM/29 nM(Tyro3/Axl/Mer)

prudect name : LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase inhibitor with IC50 of

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LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

prudect name : LX1606 is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.LX 1606;LX1606 Synonyms: CAS NO: 1033805-22-9Molecular Formula: C27H26ClF3N6O3Molecular Weight: 574.98Purity: 98% minSolubility: In DMSOStorage:…

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Linsitinib (OSI-906) is a potent, selective orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).Linsitinib (OSI-906) demonstrated robust anti-tumor activity in an IGF-1R dependent xenograft model when administered orally once a day at doses of 25 and 75 mg/kg. Linsitinib (OSI-906) not only slowed the growth of IGF-1R-dependent tumors, but also reduced proliferation and/or survival of a broad panel of tumor cell lines. Specifically, among a panel of 28 human tumor cell lines, Linsitinib (OSI-906) potently (EC50 < 400 nM) reduced growth of 15 cell lines representative of colorectal, NSCLC, pancreatic, breast and pediatric cancers. In addition to the single agent activity, simultaneous treatment with a low dose of Linsitinib (OSI-906) and Tarceva effectively blocked both AKT and MAP kinase pathways in human colorectal tumors, which resulted in a decrease in the size of pre-existing tumors which was better than the effect of either drug alone

prudect name : Linsitinib (OSI-906) is a potent, selective orally active inhibitor of the insulin-like growth factor-1 receptor (IGF-1R).Linsitinib (OSI-906) demonstrated robust anti-tumor activity in an IGF-1R dependent xenograft model…

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prudect name : Lersivirine(UK 453061)Synonyms: CAS NO: 473921-12-9Molecular Formula: C17H18N4O2Molecular Weight: 310.35Purity: 98% minSolubility: In

prudect name : Lersivirine(UK 453061) Synonyms: CAS NO: 473921-12-9Molecular Formula: C17H18N4O2Molecular Weight: 310.35Purity: 98% minSolubility: In DMSOStorage: -20°C LY-294002 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18523506

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LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. LY2608204 also stimulates glucose metabolism in rat insulinoma INS1-E cells with EC50 of 579 nM.

prudect name : LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. LY2608204 also stimulates glucose metabolism…

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LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity. LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib.

prudect name : LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity. LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers…

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LCL161 is an orally bioavailable SMAC mimetic and inhibitor of Inhibitor of Apoptosis Protein (IAP) family of proteins, with antineoplastic activity.

prudect name : LCL161 is an orally bioavailable SMAC mimetic and inhibitor of Inhibitor of Apoptosis Protein (IAP) family of proteins, with antineoplastic activity.LCL161 Synonyms: CAS NO: 1005342-46-0Molecular Formula: C26H33FN4O3SMolecular…

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LDK378 is designed to reduce the possibility of forming reactive metabolites and shows undetectable levels of glutathione (GSH) adducts (<1%) in liver microsomes. LDK378 has relatively good metabolic stability, with moderate CYP3A4 (Midazolam substrate) inhibition and hERG inhibition. LDK378 exhibits low plasma clearance in animals (mouse, rat, dog and monkey) compared to liver blood flow, with the oral bioavailability of above 55% in mouse, rat, dog and monkey. LDK378 induces a dose-dependent growth inhibition and tumor regression in the Karpas299 and H2228 rat xenograft models, with no body-weight loss. LDK378 shows no impact on insulin levels or plasma glucose utilization in the mouse upon chronic dosing up to 100 mg/kg.

prudect name : LDK378 is designed to reduce the possibility of forming reactive metabolites and shows undetectable levels of glutathione (GSH) adducts (

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Chemical Name:2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1)

prudect name : Chemical Name:2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1)LY2835219 Synonyms: CAS NO: 1231930-82-7Molecular Formula: C27H32F2N8.CH4O3SMolecular Weight: 1231930-82-7Purity: 98% minSolubility: In DMSOStorage: -20°C XL 184 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18523300

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