BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival.

 June 21, 2017

prudect name : BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1…

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prudect name : BexaroteneSynonyms: CAS NO: 153559-49-0Molecular Formula: C24H28O2Molecular Weight: 348.48Purity: 98% minSolubility: In DMSOStorage:

prudect name : Bexarotene Synonyms: CAS NO: 153559-49-0Molecular Formula: C24H28O2Molecular Weight: 348.48Purity: 98% minSolubility: In DMSOStorage: -20°C ABEMACICLIB References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503802

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prudect name : Bencynoate hydrochlorideSynonyms: CAS NO: 162220-36-2Molecular Formula: C22H32ClNO3Molecular Weight: 393.95Purity: 98% minSolubility: Storage:

prudect name : Bencynoate hydrochloride Synonyms: CAS NO: 162220-36-2Molecular Formula: C22H32ClNO3Molecular Weight: 393.95Purity: 98% minSolubility: Storage: −20°C Niraparib References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503774

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BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PKD1 than PKA and PKC, respectively. In comparison to GSK3¦Â, selectivity for PDK1 is 600-fold.

prudect name : BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PKD1 than PKA and PKC, respectively. In…

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prudect name : BI-D1870Synonyms: CAS NO: 501437-28-1Molecular Formula: C19H23F2N5O2Molecular Weight: 391.42Purity: 98% minSolubility: in DMSOStorage:

prudect name : BI-D1870 Synonyms: CAS NO: 501437-28-1Molecular Formula: C19H23F2N5O2Molecular Weight: 391.42Purity: 98% minSolubility: in DMSOStorage: -20oC DX8951f References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503755

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prudect name : BAN ORL 24Synonyms: CAS NO: 475150-69-7Molecular Formula: C27H35N3O2.2HClMolecular Weight: 506.51Purity: 98%Solubility: In

prudect name : BAN ORL 24 Synonyms: CAS NO: 475150-69-7Molecular Formula: C27H35N3O2.2HClMolecular Weight: 506.51Purity: 98%Solubility: In DMSOStorage: -20°C JQ-1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503748

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prudect name : BeraprostSynonyms: CAS NO: 88430-50-6Molecular Formula: C24H30O5Molecular Weight: 398.49Purity: 99% minSolubility: Storage: −20°C

prudect name : Beraprost Synonyms: CAS NO: 88430-50-6Molecular Formula: C24H30O5Molecular Weight: 398.49Purity: 99% minSolubility: Storage: −20°C 248281-84-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503622

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Bafetinib (INNO-406) is an orally available, dual Abl/Lyn kinase inhibitor that is up to 55-times more potent than imatinib in Bcr-Abl cell lines. Numerous Bcr-Abl mutant proteins (not T315I) are sensitive to INNO-406 in vitro. INNO-406 demonstrates specific Src kinase activity against Lyn kinase.

prudect name : Bafetinib (INNO-406) is an orally available, dual Abl/Lyn kinase inhibitor that is up to 55-times more potent than imatinib in Bcr-Abl cell lines. Numerous Bcr-Abl mutant proteins…

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BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 ¦ÌM and prevents A2780 Cytox with IC50 of 0.76 ¦ÌM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively. BMS265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 ¦ÌM-0.492 ¦ÌM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.

prudect name : BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 ¦ÌM and prevents A2780 Cytox with IC50 of 0.76 ¦ÌM. BMS265246 which binds to CDK2 shows the…

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prudect name : Bimatoprost isopropyl esterSynonyms: CAS NO: 130209-76-6Molecular Formula: C26H38O5Molecular Weight: 430.58Purity: 99% minSolubility:

prudect name : Bimatoprost isopropyl ester Synonyms: CAS NO: 130209-76-6Molecular Formula: C26H38O5Molecular Weight: 430.58Purity: 99% minSolubility: In DMSOStorage: −20°C 209216-23-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503525

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