Vitamin D4 is the active analogue of Vitamin D

 June 21, 2017

prudect name : Vitamin D4 is the active analogue of Vitamin DVitamin D4 Synonyms: CAS NO: 511-28-4Molecular Formula: C28H46OMolecular Weight: 398.66Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌
0💬 read more

Chemical Name: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide

prudect name : Chemical Name: N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamideVU 0364439 Synonyms: CAS NO: 1246086-78-1Molecular Formula: C18H13Cl2N3O3SMolecular Weight: 422.29Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌
0💬 read more

prudect name : Vortioxetine hydrobroMideSynonyms: CAS NO: 960203-27-4Molecular Formula: C18H22N2S.HBrMolecular Weight: 379.36Purity: 98% minSolubility: in

prudect name : Vortioxetine hydrobroMide Synonyms: CAS NO: 960203-27-4Molecular Formula: C18H22N2S.HBrMolecular Weight: 379.36Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

📌
0💬 read more

prudect name : VRT-1353385Synonyms: CAS NO: 1616113-45-1Molecular Formula: C36H41NO10Molecular Weight: 647.71Purity: 98% minSolubility: In DMSOStorage:

prudect name : VRT-1353385 Synonyms: CAS NO: 1616113-45-1Molecular Formula: C36H41NO10Molecular Weight: 647.71Purity: 98% minSolubility: In DMSOStorage: -20 oC web site: www.medchemexpress.com

📌
0💬 read more

VU0357121 does not have PAM activity at other mGluR subtypes, neither binds at the MPEP allosteric site of mGlu5, thus does not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration−response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line.

prudect name : VU0357121 does not have PAM activity at other mGluR subtypes, neither binds at the MPEP allosteric site of mGlu5, thus does not possess mGlu5 NAM activity. The…

📌
0💬 read more

VX-745 selectively inhibits p38¦Á and p38¦Â MAPK with IC50 of 10 nM and 220 nM, respectively, but not p38¦Ã MAPK and a large panel of other kinases, with IC50 larger than 20 µM. In a human peripheral blood mononuclear cell (PBMC) assay, VX-745 provides IC50 of 56 and 52 nM for IL-1¦Â and TNF¦Á, respectively. VX-745 blocks IL-6 and IL-8 production induced by IL-1 and TNF¦Á, and COX-2 synthesis mediated by LPS and IL-1¦Â. VX-745 (60 nM-20 µM) inhibits IL-6 and VEGF secretion in bone marrow stromal cells (BMSCs), without affecting their viability. VX-745 also inhibits TNF-¦Á-induced IL-6 secretion in BMSCs. VX-745 inhibits both multiple myeloma (MM) cell proliferation and IL-6 secretion in BMSCs triggered by adherence of MM cells to BMSCs, suggesting that VX-745 can inhibit paracrine multiple myeloma (MM) cell growth in the BM milieu and overcome cell adhesion-related drug resistance.

prudect name : VX-745 selectively inhibits p38¦Á and p38¦Â MAPK with IC50 of 10 nM and 220 nM, respectively, but not p38¦Ã MAPK and a large panel of other kinases,…

📌
0💬 read more

VX-765 is a novel and irreversible IL-converting enzyme/caspase-1 inhibitor with an IC50 of 0.8 nM. VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases is an active metabolite VX-765. VRT-043198 exhibits 100-10,000-fold selectivity against other caspase-3 and -6-9. VX-765 was efficiently converted to VRT-043198 when administered orally to mice and inhibited LPS-induced cytokine secretion. VX-765 has been shown to inhibit acute partial seizures in preclinical models and has shown activity in preclinical models of chronic partial epilepsy that do not respond to currently available medicines for epilepsy. In addition, VX-765 reduced disease severity and the expression of inflammatory mediators in models of rheumatoid arthritis and skin inflammation.

prudect name : VX-765 is a novel and irreversible IL-converting enzyme/caspase-1 inhibitor with an IC50 of 0.8 nM. VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases is an…

📌
0💬 read more

UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.

prudect name : UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3 with Kd value of 120 nM.UNC 1215;UNC1215;UNC-1215 Synonyms: CAS NO: 1415800-43-9Molecular…

📌
0💬 read more

UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM, respectively.

prudect name : UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM, respectively.UNC-1999 Synonyms: CAS NO: 1431612-23-5Molecular Formula:…

📌
0💬 read more

UMI-77 is a novel selective Mcl-1 SMI inhibitor. UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

prudect name : UMI-77 is a novel selective Mcl-1 SMI inhibitor. UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members…

📌
0💬 read more
« Previous
1 … 675 676 677 678 679 … 888
Next »