BMS-345541 is a cell-permeable quinoxaline compound that shows anti-inflammatory properties. BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK ¦Â (IKK-2). Displays ~10-fold greater selectivity over IKK ¦Á (IKK-1) and no activity towards IKK¦Å and a panel of more than 15 unrelated protein kinases even at concentrations as high as 100 ¦ÌM. Inhibits cellular I¦ÊB¦Á phosphorylation.

 June 21, 2017

prudect name : BMS-345541 is a cell-permeable quinoxaline compound that shows anti-inflammatory properties. BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK ¦Â (IKK-2). Displays ~10-fold greater selectivity…

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BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

prudect name : BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which…

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prudect name : BazedoxifeneSynonyms: CAS NO: 198481-32-2Molecular Formula: C30H34N2O3Molecular Weight: 470.6026Purity: 98% minSolubility: In DMSOStorage:

prudect name : Bazedoxifene Synonyms: CAS NO: 198481-32-2Molecular Formula: C30H34N2O3Molecular Weight: 470.6026Purity: 98% minSolubility: In DMSOStorage: -20°C Apabetalone References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504058/

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Insulin-like Growth Factor-1 Receptor Inhibitor; 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

prudect name : Insulin-like Growth Factor-1 Receptor Inhibitor; 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinoneBMS-536924 Synonyms: CAS NO: 468740-43-4Molecular Formula: C25H26ClN5O3Molecular Weight: 479.96Purity: 98% minSolubility: In DMSOStorage: -20°C IPI-549 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1850405

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BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.

prudect name : BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated…

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prudect name : BiapenemSynonyms: CAS NO: 120410-24-4Molecular Formula: C15H18N4O4SMolecular Weight: 350.39Purity: 98% minSolubility: Storage: −20°C

prudect name : Biapenem Synonyms: CAS NO: 120410-24-4Molecular Formula: C15H18N4O4SMolecular Weight: 350.39Purity: 98% minSolubility: Storage: −20°C GDC-0199 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503899

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prudect name : Bafilomycin A1Synonyms: CAS NO: 88899-55-2Molecular Formula: C35H58O9Molecular Weight: 622.83Purity: 98% minSolubility: Storage:

prudect name : Bafilomycin A1 Synonyms: CAS NO: 88899-55-2Molecular Formula: C35H58O9Molecular Weight: 622.83Purity: 98% minSolubility: Storage: −20°C KPT-9274 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503878

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BMS-806, a 7-azaindole derivative, binds gp120 and interferes with the interaction of HIV surface protein gp120 with the host cell receptor CD4. BMS-806 inhibits a panel of macrophage- and T cell-tropic HIV-1 strains, which are laboratory strains that use either CCR5 (M-tropic) or CXR4 (T-tropic) co-receptors to enter cells and are classified as B subtypes. The aqueous solubility from the crystalline form of BMS-806 (BMS 378806) is 170 ¦Ìg/mL. The solubility of BMS-806 is 1.3 mg/mL at pH=2.1 and 3.3 mg/mL at pH=11, a solubility profile that reveals the amphoteric nature of BMS-806 and estimates the pKa of the protonated form as 2.9 while that of the free base is approximately 9.6. BMS-806 competes with soluble CD4 binding to a monomeric form of gp120 in an ELISA assay with IC50 = ~ 100 nM. BMS-806 is specific towards HIV-1, with no significant inhibitory activity against HIV-2, SIV, MuLV, RSV, HCMV, BVDV, VSV, and influenza virus observed at concentrations ranging from 10 to 30 ¦ÌM and no overt cytotoxicity toward host cells, CC50 values > 225 ¦ÌM. BMS-806 binds directly to gp120 at a stoichiometry of approximately 1:1, with a binding affinity similar to that of soluble CD4. The potential BMS-806 target site is localized to a specific region within the CD4 binding pocket of gp120 by using HIV-1 gp120 variants carrying either compound-selected resistant substitutions or gp120-CD4 contact site mutations.

prudect name : BMS-806, a 7-azaindole derivative, binds gp120 and interferes with the interaction of HIV surface protein gp120 with the host cell receptor CD4. BMS-806 inhibits a panel of…

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prudect name : Bremelanotide PT 141Synonyms: CAS NO: 189691-06-3Molecular Formula: C50H68N14O10Molecular Weight: 1025.16Purity: 98% minSolubility:

prudect name : Bremelanotide PT 141 Synonyms: CAS NO: 189691-06-3Molecular Formula: C50H68N14O10Molecular Weight: 1025.16Purity: 98% minSolubility: Storage: -20°C ABT-263 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503854

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BMS-790052 is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex. BMS-790052 has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm). BMS-790052 produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.

prudect name : BMS-790052 is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex. BMS-790052 has broad genotype coverage and…

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