VX-809 may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF. Defects in the CFTR protein affect the transport of chloride and other ions across cells, and lead to the accumulation of thick, sticky mucus in the lungs of patients with CF. This mucus fosters chronic infection and inflammation, and results in irreversible lung damage.

 June 21, 2017

prudect name : VX-809 may act to restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, the defective cell membrane protein responsible for the progression of CF….

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Verteporfin (trade name Visudyne) is a benzoporphyrin derivative and is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Verteporfin is also used off-label for the treatment of central serous retinopathy.

prudect name : Verteporfin (trade name Visudyne) is a benzoporphyrin derivative and is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the…

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VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. IC50 value: Target: ERK

prudect name : VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent. IC50 value: Target: ERKVX-11e Synonyms: CAS NO: 896720-20-0Molecular Formula: C24H20Cl2FN5O2Molecular Weight:…

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The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6, IL-12 and IFN¦Ã , all of which have been demonstrated to play important roles in autoimmune diseases such as rheumatoid arthritis (RA) and/or cardiovascular diseases. In an ex vivo blood assay primed with LPS, VX-702 dose-dependently inhibited the production of IL-6, IL-1¦Â and TNF¦Á (IC50 = 59, 122 and 99 ng/ml, respectively)

prudect name : The activation of p38 MAPKs leads to gene transcription and translation, followed by an increase in production of inflammatory mediators, such as TNF¦Á, IL-1¦Â, cyclooxygenase (COX)-2, IL-6,…

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Voglibose for the improvement of postprandial hyperglycemia in diabetes mellitus

prudect name : Voglibose for the improvement of postprandial hyperglycemia in diabetes mellitusVoglibose Synonyms: 5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrolCAS NO: 83480-29-9Molecular Formula: C10H21NO7Molecular Weight: 267.13Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid

prudect name : Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acidVitamin H; Vitamin B7; D-Biotin Synonyms: CAS NO: 58-85-5 (22879-79-4)Molecular Formula: C10H16N2O3SMolecular Weight: 244.31Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com

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Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25 mg /kg/ day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.

prudect name : Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine…

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This product is synthesis of vinblastine sulfate, vinorelbine, vinblastine and other raw materials for dehydration.

prudect name : This product is synthesis of vinblastine sulfate, vinorelbine, vinblastine and other raw materials for dehydration.Vindoline Synonyms: CAS NO: 2182-14-1Molecular Formula: C25H32N2O6Molecular Weight: 456.54Purity: 99%Solubility: In DMSOStorage: −20°C…

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prudect name : Vindesine sulfateSynonyms: Desacetylvinblastine amide sulfate (1:1)CAS NO: 59917-39-4Molecular Formula: C43H55N5O7.H2SO4Molecular Weight: 852.01Purity:

prudect name : Vindesine sulfate Synonyms: Desacetylvinblastine amide sulfate (1:1)CAS NO: 59917-39-4Molecular Formula: C43H55N5O7.H2SO4Molecular Weight: 852.01Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

prudect name : Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of…

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