LY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

 June 21, 2017

prudect name : LY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.LY2409881…

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LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. (IC50 of 13 nM, 6 nM, and 2.45 ¦ÌM for wild type, G2019S mutant, and drug resistant A2016T mutant LRRK2, respectively, in an in vitro ATP-site competititon binding assay). LRRK2-IN-1 is useful in treatment of Parkinson¡¯s disease.

prudect name : LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. (IC50 of 13 nM, 6 nM, and 2.45 ¦ÌM for wild type, G2019S mutant, and drug…

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LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.

prudect name : LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.LY-2584702;LY2584702 Synonyms: CAS NO: 1082949-67-4Molecular Formula: C21H19F4N7Molecular Weight:…

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LY294002 inactivates Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis. LY294002 demonstrates a remarkable growth-inhibitory and apoptosis-inducing effect in these colon cancer cell lines, with decreased expression of phosphorylated Akt (Ser473).LY294002 induces marked nuclear pyknosis and diminished cytoplasmic volume in the tumor cells. Thus, LY294002 markedly inhibits ovarian cancer cell proliferation in vitro. LY294002 induces specific G1 arrest in cell growth, leading to almost complete inhibition of melanoma cell proliferation and partial inhibition of MG-63 (osteosarcoma cell line) proliferation. The effect of LY294002 on cell cycle progression may provide insights into a possible link between the PI3K activation pathway and cancer cell cycle regulation.

prudect name : LY294002 inactivates Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis. LY294002 demonstrates a remarkable growth-inhibitory and apoptosis-inducing effect in these colon cancer cell lines, with decreased expression…

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prudect name : LapatinibSynonyms: CAS NO: 231277-92-2Molecular Formula: C29H26ClFN4O4SMolecular Weight: 581.06Purity: 99%Solubility: In DMSOStorage: −20°C

prudect name : Lapatinib Synonyms: CAS NO: 231277-92-2Molecular Formula: C29H26ClFN4O4SMolecular Weight: 581.06Purity: 99%Solubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524324

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Laquinimod treatment at 0.1-1 ¦ÌM does not affect the viability of peripheral blood mononuclear cells (PBMC). By performing the large-scale gene expression microarray analysis in PBMC from healthy subjects or relapsing-remitting multiple sclerosis (RRMS) patients, Laquinimod is shown to induce suppression of genes related to antigen presentation and corresponding inflammatory pathways. Laquinimod induces activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. Laquinimod displays significant effects on immune modulation related to the suppression of antigen presenting mechanism followed by a decrease of chemotaxis and adhesion, and exhibits potent anti-inflammatory potency through the suppression of the NF-¦ÊB pathway that concordantly leads to the activation of apoptosis of immuno-competent cells.

prudect name : Laquinimod treatment at 0.1-1 ¦ÌM does not affect the viability of peripheral blood mononuclear cells (PBMC). By performing the large-scale gene expression microarray analysis in PBMC from…

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LY2784544 also inhibits IL-3-activated wild type JAK2 with IC50 of 2.26 ¦ÌM. Similarly in the proliferation assay, LY2784544 shows antiproliferation activity in JAK2 V617F-driven cells with IC50 of 68 nM, compared to 1.36 ¦ÌM in wild type JAK2-driven cells and 0.94 ¦ÌM in JAK3-driven cells.LY2784544 significantly inhibits STAT5 phosphorylation in Ba/F3-JAK2 V617F-GFP xenografts with a Threshold Effective Dose 50 (TED50) of 12.7 mg/kg. LY2784544 also reduces Ba/F3-JAK2 V617F-GFP tumor burden in the JAK2 V617F-induced MPN model with a TED50 of 13.7 mg/kg after oral treatment. LY2784544 has no effect on CD71/Ter119 positive erythroid progenitors in spleens of SCID mice after oral treatment.

prudect name : LY2784544 also inhibits IL-3-activated wild type JAK2 with IC50 of 2.26 ¦ÌM. Similarly in the proliferation assay, LY2784544 shows antiproliferation activity in JAK2 V617F-driven cells with IC50…

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prudect name : Lypressin AcetateSynonyms: CAS NO: 50-57-7Molecular Formula: C46H65N13O12S2Molecular Weight: 1056.22Purity: 98% minSolubility: Storage:

prudect name : Lypressin Acetate Synonyms: CAS NO: 50-57-7Molecular Formula: C46H65N13O12S2Molecular Weight: 1056.22Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524194

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[1,​1¡¯-​Biphenyl]​-​4-​propanoic acid, 3¡¯-​chloro-​¦Á-​[[(1S)​-​2-​ethoxy-​1-​methyl-​2-​oxoethyl]​amino]​-​, (¦ÁS)​-

prudect name : [1,​1¡¯-​Biphenyl]​-​4-​propanoic acid, 3¡¯-​chloro-​¦Á-​[[(1S)​-​2-​ethoxy-​1-​methyl-​2-​oxoethyl]​amino]​-​, (¦ÁS)​-LHW090-A7 Synonyms: CAS NO: 1308256-94-1Molecular Formula: C20H22ClNO4 Molecular Weight: 375.85 Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524192

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prudect name : Leuprorelin acetateSynonyms: CAS NO: 74381-53-6Molecular Formula: C59H84N16O12.C2H4O2Molecular Weight: 1269.45Purity: 98% minSolubility: Storage:

prudect name : Leuprorelin acetate Synonyms: CAS NO: 74381-53-6Molecular Formula: C59H84N16O12.C2H4O2Molecular Weight: 1269.45Purity: 98% minSolubility: Storage: -20°C VS4718 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1852398

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