LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. LY411575 has been exhibited to promote goblet cell differentiation in mice intestine. Concurrently, LY411575 prevents the proliferation of the cell proliferation. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells3. The gamma-secretase inhibitor LY411575 was injected to C57BL/6 and TgCRND8 APP transgenic mice for 15 days. Although most tissues were unaffected, doses of LY411575 which prevented the production of A¦Â had significant effects on lymphocyte development and on the intestine. LY411575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD4-CD8-CD44+CD25+ precursor stage. No effects on peripheral T cell populations were observed following LY411575 treatment, but evidence for the altered maturation of peripheral B cells was observed. In the intestine, LY411575 treatment increased goblet cell number and drastically altered tissue morphology. These effects of LY411575 were not noted in mice that were administered LY-D, a diastereoisomer of LY411575, which is a very weak ¦Ã-secretase inhibitor.

 June 21, 2017

prudect name : LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. LY411575 has been exhibited…

📌
0💬 read more

LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 ¦ÌM (A2780) and 0.32 ¦ÌM (A2780 CisR).

prudect name : LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 ¦ÌM (A2780) and…

📌
0💬 read more

prudect name : LovastatinSynonyms: CAS NO: 75330-75-5Molecular Formula: C24H36O5Molecular Weight: 404.54Purity: 98% minSolubility: Storage: -20°C

prudect name : Lovastatin Synonyms: CAS NO: 75330-75-5Molecular Formula: C24H36O5Molecular Weight: 404.54Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524878/

📌
0💬 read more

4-[(Hexylcarbamoyl)Amino]-N-[4-(2-{[(2S)-2-Hydroxy-3-(4-Hydroxyphenoxy)Propyl]Amino}Ethyl)Phenyl]Benzenesulfonamide

prudect name : 4-[(Hexylcarbamoyl)Amino]-N-[4-(2-{[(2S)-2-Hydroxy-3-(4-Hydroxyphenoxy)Propyl]Amino}Ethyl)Phenyl]BenzenesulfonamideL755507 Synonyms: CAS NO: 159182-43-1Molecular Formula: C30H40N4O6SMolecular Weight: 584.73Purity: 98% minSolubility: In DMSOStorage: -20 oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524877

📌
0💬 read more

Lesinurad sodium (RDEA594 sodium) is an once-daily inhibitor of URAT1; URAT1 is a transporter in the kidney that regulates uric acid excretion from the body.

prudect name : Lesinurad sodium (RDEA594 sodium) is an once-daily inhibitor of URAT1; URAT1 is a transporter in the kidney that regulates uric acid excretion from the body.Lesinurad(RDEA594) sodium Synonyms:…

📌
0💬 read more

Lenalidomide (Revlimid) is a derivative of thalidomide with antiangiogenic and antineoplastic properties(cell IC50= 10 ¦ÌM). [1] It was initially intended as a treatment for multiple myeloma.Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells.

prudect name : Lenalidomide (Revlimid) is a derivative of thalidomide with antiangiogenic and antineoplastic properties(cell IC50= 10 ¦ÌM). [1] It was initially intended as a treatment for multiple myeloma.Lenalidomide inhibits…

📌
0💬 read more

LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.

prudect name : LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.LY2183240 Synonyms: CAS NO: 874902-19-9Molecular Formula: C17H17N5OMolecular Weight: 307.35Purity: 98% minSolubility: In DMSOStorage: −20°C web…

📌
0💬 read more

Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases.

prudect name : Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases.Lapatinib ditosylate Synonyms: GW-572016CAS NO: 388082-78-8Molecular Formula: C29H26ClFN4O4S.2(C7H8O3S)Molecular Weight: 925.46Purity: 99%Solubility:…

📌
0💬 read more

Lornoxicam non-steroidal anti-inflammatory analgesic drugs, the Department of thiazide derivatives

prudect name : Lornoxicam non-steroidal anti-inflammatory analgesic drugs, the Department of thiazide derivativesLornoxicam Synonyms: CAS NO: 70374-39-9Molecular Formula: C13H10ClN3O4S2Molecular Weight: 371.82Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References…

📌
0💬 read more

prudect name : LonafarnibSynonyms: Sch-66336, SarasarCAS NO: 193275-84-2Molecular Formula: C27H31Br2ClN4O2Molecular Weight: 638.82Purity: 98% minSolubility: Storage:

prudect name : Lonafarnib Synonyms: Sch-66336, SarasarCAS NO: 193275-84-2Molecular Formula: C27H31Br2ClN4O2Molecular Weight: 638.82Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524756

📌
0💬 read more
« Previous
1 … 672 673 674 675 676 … 825
Next »