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Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 ¦ÌM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, enhance Ca2+ fluxes and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) accelerates productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.

June 21, 2017

prudect name : Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 ¦ÌM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently…

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prudect name : Catharanthine sulfateSynonyms: CAS NO: 70674-90-7Molecular Formula: C21H24N2O2.H2SO4Molecular Weight: 434.51Purity: 98% minSolubility: In

prudect name : Catharanthine sulfate Synonyms: CAS NO: 70674-90-7Molecular Formula: C21H24N2O2.H2SO4Molecular Weight: 434.51Purity: 98% minSolubility: In DMSOStorage: -20°C INCB039110 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505772

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CAY10505 is a potent PI3K¦Ã inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase ¦Ã (PI3K¦Ã) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505 also prevents other ¦Á, ¦Â, and ¦Ä isoforms with IC50 of 0.94, 20, and 20 ¦ÌM, respectively. CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505 also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505 decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K¦Ã-deficient mice.

prudect name : CAY10505 is a potent PI3K¦Ã inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase ¦Ã (PI3K¦Ã) is expressed primarily in hematopoietic cells and plays several important roles…

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PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM.

prudect name : PHA-767491 (CAY10572) is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM.CAY10572;PHA 767491 Synonyms: CAS NO: 845714-00-3Molecular Formula: C12H11N3OMolecular Weight: 213.24Purity: 98% minSolubility: in…

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Basmisanil, also known as RG1662, RO5186582, is a highly selective inverse agonist/negative allosteric modulator of ¦Á5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. As of August 2015, it is in phase II clinical trials for this indication. Down syndrome (DS) is the most commonly identifiable genetic form of intellectual disability. Individuals with DS have considerable deficits in intellectual functioning (i.e., low intellectual quotient, delayed learning and/or impaired language development) and adaptive behavior.

prudect name : Basmisanil, also known as RG1662, RO5186582, is a highly selective inverse agonist/negative allosteric modulator of ¦Á5 subunit-containing GABAA receptors which is under development by Roche for the…

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BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.

prudect name : BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.BAY 87-2243 Synonyms: CAS NO: 1227158-85-1Molecular Formula: C26H26F3N7O2Molecular Weight: 525.53Purity: 98% minSolubility: DMSOStorage: -20¡æ PF…

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Napabucasin is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.

prudect name : Napabucasin is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.BBI608£»Napabucasin Synonyms:…

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Bleomycin sulfate for the broad-spectrum antitumor antibiotic.

prudect name : Bleomycin sulfate for the broad-spectrum antitumor antibiotic.Bleomycin sulfate Synonyms: CAS NO: 9041-93-4Molecular Formula: C55H84N17O21S3.HSO4Molecular Weight: 1512.62Purity: 95%Solubility: Storage: −20°C 2 years NXL-104 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505681

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Emeramide, also known as BDTH2, a mercury chelator and an antioxidant, for the treatment of mercury poisoning. Phase I development is underway. BDTH2 is a colourless solid. The molecule consists of two thiol groups and linked via a pair of amide groups. BDTH2 can be used to chelate heavy metals like lead, cadmium, copper, manganese, zinc, iron, and mercury from ground water, coal tailings, gold ore, waste water of battery-recycling plants, and contaminated soil.

prudect name : Emeramide, also known as BDTH2, a mercury chelator and an antioxidant, for the treatment of mercury poisoning. Phase I development is underway. BDTH2 is a colourless solid….

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BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.

prudect name : BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.BMS663068 Fostemsavir Synonyms: CAS NO: 864953-29-7Molecular Formula: C25H26N7O8PMolecular Weight: 583.49Purity: 98% minSolubility: In DMSOStorage:…

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