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Maraviroc is a new class of oral HIV treatment drug.

June 21, 2017

prudect name : Maraviroc is a new class of oral HIV treatment drug.Maraviroc Synonyms: Selzentry, UK-427857, CelsentriCAS NO: 376348-65-1Molecular Formula: C29H41F2N5OMolecular Weight: 513.67Purity: 99%Solubility: Storage: −20°C 2 years web site:…

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prudect name : methyl 4-(2-hydroxyethoxy)-3-methoxybenzoateSynonyms: CAS NO: 21903-52-6Molecular Formula: C11H14O5Molecular Weight: 226.23Purity: 98% minSolubility: Storage:

prudect name : methyl 4-(2-hydroxyethoxy)-3-methoxybenzoate Synonyms: CAS NO: 21903-52-6Molecular Formula: C11H14O5Molecular Weight: 226.23Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525111

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3-(2-Chloroethyl)-3,4-Dihydro-4-Oxoimidazo[5,1-D]-1,2,3,5-Tetrazine-8-Carboxamide; Imidazo(5,1-D)-1,2,3,5-Tetrazine-8-Carboxamide,3-(2-Chloroethyl)-3,4-Dihydro-4; 3-(2-Chloroethyl)-3,4-Dihydro-4-Oxoimidazo(5,1-D)-1,2,3,5-Tetrazine-8-Carbox

prudect name : 3-(2-Chloroethyl)-3,4-Dihydro-4-Oxoimidazo[5,1-D]-1,2,3,5-Tetrazine-8-Carboxamide; Imidazo(5,1-D)-1,2,3,5-Tetrazine-8-Carboxamide,3-(2-Chloroethyl)-3,4-Dihydro-4; 3-(2-Chloroethyl)-3,4-Dihydro-4-Oxoimidazo(5,1-D)-1,2,3,5-Tetrazine-8-CarboxMitozolomide Synonyms: CAS NO: 85622-95-3 Molecular Formula: C7H7ClN6OMolecular Weight: 242.62Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525082

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BIBF-1120 intermediates

prudect name : BIBF-1120 intermediatesMethyl 2-oxoindole-6-carboxylate Synonyms: CAS NO: 14192-26-8Molecular Formula: C10H9NO3Molecular Weight: 191.18Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525052

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Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors.

prudect name : Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine…

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Mizoribine applied to the same kind of immunosuppressive therapy after kidney transplantation.

prudect name : Mizoribine applied to the same kind of immunosuppressive therapy after kidney transplantation.Mizoribine Synonyms: CAS NO: 50924-49-7Molecular Formula: C9H13N3O6Molecular Weight: 259.22Purity: ≥99%Solubility: In DMSOStorage: −20°C 2 years web…

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MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1]. MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator¨Cactivated receptor-¦Ã (PPAR-¦Ã)-dependent side effects. Co-incubation of islets with MSDC-0160 and IGF-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. MSDC-0160 at 50¦ÌM alone also prevents the loss of insulin content significantly. Besides that, treatment of MSDC-0160 increases the phosphorylation of AMPK and reduces mTOR phosphorylation. Moreover, MSDC-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. In addition, MSDC-0160 exerts prevention of nuclear translocation with ¦Â-catenin localized on the cell membrane or cytoplasm in human ¦Â-cells

prudect name : MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1]. MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator¨Cactivated receptor-¦Ã (PPAR-¦Ã)-dependent side effects. Co-incubation of islets with MSDC-0160…

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Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

prudect name : Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochlorideML 7 hydrochloride Synonyms: CAS NO: 110448-33-4Molecular Formula: C15H17IN2O2S.HClMolecular Weight: 452.74Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525034

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Maropitant (trade name Cerenia in the US and other countries), used as maropitant citrate (USAN), is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007 for use in dogs, and more recently has also been approved for use in cats.

prudect name : Maropitant (trade name Cerenia in the US and other countries), used as maropitant citrate (USAN), is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically…

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Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 ¦ÌM).

prudect name : Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 ¦ÌM).MK-3102;Omarigliptin Synonyms: CAS NO:…

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