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Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

June 21, 2017

prudect name : Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamineWZ 811 Synonyms: CAS NO: 55778-02-4Molecular Formula: C18H18N4Molecular Weight: 290.36Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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WS6 is a novel small molecule that promotes ¦Â cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).

prudect name : WS6 is a novel small molecule that promotes ¦Â cell proliferation in rodent and human primary islets with EC50 of 0.28 uM(R7T1 cell viability).WS6;WS-6;WS-6 Synonyms: CAS NO:…

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WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38¦Á and KDR.

prudect name : WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38¦Á and KDR.WH-4-023…

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WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ¡À 0.12 nM for 5-HT. Intravenous administration of WAY-100635 (0.025-0.5 mg/kg) markedly improved neuronal activity. The stimulatory action of WAY-100635 was evident during wakefulness (when serotonergic neurons typically display a relatively high level of activity) but not during sleep (when serotonergic neurons display little or no spontaneous activity). WAY-100635 at doses as low as 0.1 mg/kg i.v. completely blocked the action of 8-hydroxy-2-(di-n-propylamino)tetralin. The antagonist action of WAY-100635 at 5-HT1A autoreceptors closely paralleled its ability to increase neuronal activity.

prudect name : WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ¡À 0.12 nM for 5-HT. Intravenous administration of WAY-100635 (0.025-0.5 mg/kg) markedly improved neuronal…

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WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM. WYE-125132 blocked the activity of the both of mTORC1 and mTORC2 in various models of cancer in vitro and in vivo. WYE-125132 is 5,000-fold more selective than PI3Ks. Moreover, WYE-125132 completely blocked amino acid-induced phosphorylation of Maf1, just as S6K1, and 4E-BP1 via the inhibition of mTOR. WYE-132-treated MG63 markedly upregulated the Maf1 amouts in the nucleus. WYE-125132 showed a substantially more effective inhibition in many respects, including cancer cell growth and survival, protein synthesis bioenergetic metabolism, and adaptation to hypoxia by contrast with the rapalog temsirolimus/CCI-779.

prudect name : WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM. WYE-125132 blocked the activity of the both of mTORC1 and…

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WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines and WZ4002 prevents of EGFR phosphorylation in NIH-3T3 cells expressing different EGFR T790M mutant alleles. For WZ4002, kinases that exhibited greater than 95% inhibition relative to the DMSO control at 10 ¦ÌM are selected for measurement of their dissociation constants. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR compared to WZ3146. WZ4002 is 100-fold less effective at inhibiting phosphorylation of WT EGFR compared to the quinazoline inhibitors. Similarly, WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 and gefitinib.

prudect name : WZ4002 inhibits other EGFR genotypes E746_A750 and E746_A750/T790M with IC50 of 2 and 6 nM. Besides, WZ4002 suppresses widetype ERBB2 with an IC50 of 32 nM. WZ4002…

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WS3 is a novel small molecule that promotes ¦Â cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).

prudect name : WS3 is a novel small molecule that promotes ¦Â cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).WS3;WS-3;WS 3 Synonyms: CAS NO: 1421227-52-2Molecular Formula: C28H30F3N7O3Molecular Weight: 569.58Purity:…

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WP1130 is a novel selective small molecular deubiquitinase (DUB) inhibitor and a Bcr/Abl destruction pathway activator with an IC50 of 1.8 ¦ÌM for K562 cells. WP1130 acts as a partly selective deubiquitinases (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53.

prudect name : WP1130 is a novel selective small molecular deubiquitinase (DUB) inhibitor and a Bcr/Abl destruction pathway activator with an IC50 of 1.8 ¦ÌM for K562 cells. WP1130 acts…

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Walrycin B is a novel antibacterial compound specifically targeting the essential WalR response regulator.

prudect name : Walrycin B is a novel antibacterial compound specifically targeting the essential WalR response regulator.Walrycin B Synonyms: CAS NO: 878419-78-4Molecular Formula: C14H10F3N5O2Molecular Weight: 337.26Purity: 98% minSolubility: in DMSOStorage:…

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WZ4003 is a first potent and highly specific protein kinase inhibitor of NUAK kinases with IC50 of 20 nM/100 nM for NUAK1/NUAK2; no significant inhibition on 139 other kinases.

prudect name : WZ4003 is a first potent and highly specific protein kinase inhibitor of NUAK kinases with IC50 of 20 nM/100 nM for NUAK1/NUAK2; no significant inhibition on 139…

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