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prudect name : Mycophenolic acidSynonyms: CAS NO: 24280-93-1Molecular Formula: C17H20O6Molecular Weight: C17H20O6Purity: 98% minSolubility: In

June 21, 2017

prudect name : Mycophenolic acid Synonyms: CAS NO: 24280-93-1Molecular Formula: C17H20O6Molecular Weight: C17H20O6Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18528427

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2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide. IC50 Value: 182 mM (decreased superoxide anion production stimulated with PMA (tetradecanoylphorbol acetate) in PMN in-vitro); 70mM (inhibited H2O2 production)

prudect name : 2-mercaptoethane sulfonate (Mesna), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced…

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MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose-dependent insulin secretion. Preclinical data indicate that MBX-2982 is a potent selective orally-active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the beta cell to increase insulin secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health.

prudect name : MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate…

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MCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 ¡À 0.01 for the human NOP receptor. MCOPPB exhibits anxiolytic effects with no effect on memory or locomotion. MCOPPB was regarded as one of the most potent, non-peptide NOP full agonists in vitro. MCOPPB has a high affinity for the human NOP receptor. MCOPPB has a high selectivity for the NOP receptor over other members of the opioid receptor family: 12-, 270- and >1000-fold more selective for the NOP receptor than for the micro-, kappa-, and delta-receptor, respectively. In an ex vivo binding study, MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that MCOPPB penetrated into the brain after MCOPPB was orally administered. In the mouse Vogel conflict test, MCOPPB (10 mg/kg, p.o.) and diazepam (3 mg/kg, p.o.) elicited anxiolytic-like effects, although MCOPPB produced a bell-shaped response curve. MCOPPB at an oral dose of 10 mg/kg did not affect locomotor activity or memory, nor did MCOPPB contribute to ethanol-induced hypnosis.

prudect name : MCOPPB trihydrochloride is a trihydrochloride form of MCOPPB that is a new nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist with a pKi of 10.07 ¡À 0.01 for the…

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Telmisartan£¨CAS NO£º144701-48-4£©intermediates

prudect name : Telmisartan£¨CAS NO£º144701-48-4£©intermediatesMethyl 4’-Bromomethylbiphenyl-2-Carboxylate Synonyms: CAS NO: 114772-38-2Molecular Formula: C15H13BrO2Molecular Weight: 305.17Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18528313

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MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK-8245 displays similar potencies against human, rat and mouse SCD1 with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. MK-8245 exhibits a significant SCD inhibition in the rat hepatocyte assay which contains functional, active OATPs with an IC50 of 68 nM, while being only weakly active in the HepG2 cell assay which is devoid of active OATPs with an IC50 of ~1 ¦ÌM. MK-8245 displays highly selective activity for the ¦¤-5 and ¦¤-6 desaturases (i.e., >100000 ¦ÌM vs rat and human ¦¤5D and ¦¤6D as assessed in the HepG assay.

prudect name : MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key…

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Motesanib (AMG-706) is an orally bioavailable diphosphate salt of a multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity[1]. This reagent selectively targets and inhibits VEGFR1/2/3(IC50: 2 nM /3 nM /6 nM), PDGFR (84nM), kit (8nM), and Ret (59nM)receptors, thereby inhibiting angiogenesis and cellular proliferation. Oral administration of AMG 706 potently inhibited VEGF-induced angiogenesis in the rat corneal model and induced regression of established A431 xenografts

prudect name : Motesanib (AMG-706) is an orally bioavailable diphosphate salt of a multiple receptor tyrosine kinase inhibitor with potential antineoplastic activity[1]. This reagent selectively targets and inhibits VEGFR1/2/3(IC50: 2…

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MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue. It abrogates a DNA damage checkpoint (G2-phase), leading to apoptosis in combination with several DNA-damaging agents selectively in p53-deficient tumor cell lines. It is under clinical trial for advanced solid tumors.

prudect name : MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. It abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15…

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MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).

prudect name : MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).MLN 4924 Synonyms: CAS NO: 905579-51-3;1160295-21-5(HCl salt)Molecular Formula: C21H25N5O4SMolecular Weight: 443.52Purity: 98%…

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Telmisartan CAS NO£º144701-48-4 intermediates

prudect name : Telmisartan CAS NO£º144701-48-4 intermediatesMethyl-4-(Butyrylamino)-3-Methyl-5-Nitrobenzoate Synonyms: CAS NO: 152628-01-8Molecular Formula: C13H16N2O5Molecular Weight: 280.28Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1852726

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