Chemical Name: 4-[(4¡¯-Chloro-2¡¯-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride

 June 21, 2017

prudect name : Chemical Name: 4-[(4¡¯-Chloro-2¡¯-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochlorideZM 306416 hydrochloride Synonyms: CAS NO: 690206-97-4Molecular Formula: C16H13N3O2FCl.HClMolecular Weight: 370.21Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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ZM 323881 HYDROCHLORIDE;5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL HYDROCHLORIDE

prudect name : ZM 323881 HYDROCHLORIDE;5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL HYDROCHLORIDEZM323881 Synonyms: CAS NO: 324077-30-7Molecular Formula: C22H19ClFN3O2Molecular Weight: 411.8565632Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-¦Ã coactivator-1¦Á (PGC-1¦Á).

prudect name : ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-¦Ã coactivator-1¦Á (PGC-1¦Á).ZLN005 Synonyms: CAS NO: 49671-76-3Molecular Formula: C17H18N2Molecular Weight: 250.34Purity: 98% minSolubility: in DMSOStorage: -20oC web site:…

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Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.

prudect name : Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y320;Y-320 Synonyms: CAS NO:…

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prudect name : YM90KhydrochlorideSynonyms: CAS NO: 154164-30-4Molecular Formula: C11H7N5O4.HClMolecular Weight: 309.67Purity: 98% minSolubility: In DMSOStorage:

prudect name : YM90Khydrochloride Synonyms: CAS NO: 154164-30-4Molecular Formula: C11H7N5O4.HClMolecular Weight: 309.67Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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prudect name : YK 4-279Synonyms: YK-4-279CAS NO: 1037184-44-3Molecular Formula: C17H13Cl2NO4Molecular Weight: 366.20Purity: 98% minSolubility: in

prudect name : YK 4-279 Synonyms: YK-4-279CAS NO: 1037184-44-3Molecular Formula: C17H13Cl2NO4Molecular Weight: 366.20Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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Activation of excitatory receptors coupled to G-proteins can cause contraction of smooth muscle by increasing Ca2+-sensitivity without changing [Ca2+]. This pathway involves RhoA, a small, monomeric G-protein that activates Rho-kinase. Contractions elicited with EFS were inhibited with Y-27632 (1 nM¨C300¦ÌM). The inhibition was partial (97.0¡À1.5% and 85.6¡À3.6% inhibition at 300¦ÌM) with an IC50 of 3.3¡À0.25¦ÌM and 2.8¡À0.2 ¦ÌM in human and rabbit tissues respectively . The IC50 value (concentration that inhibits 50% of the response) of Y-27632 was 1 ¡À 0.2 µmol/L for the inhibition of shape change by U46619

prudect name : Activation of excitatory receptors coupled to G-proteins can cause contraction of smooth muscle by increasing Ca2+-sensitivity without changing [Ca2+]. This pathway involves RhoA, a small, monomeric G-protein…

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YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 ¦ÌM. YM155 significantly inhibits endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 through transcriptional inhibition of the survivin gene promoter. On the contrary YM155 shows no sufficient effect on protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, ¦Á-actin, and ¦Â-tubulin at 100 nM. YM155 indicates great apoptosis in human cancer cell lines including PC-3 and PPC-1 with a concomitant increase in caspase-3 activity. YM155 potently inhibits human cancer cell lines (mutated or truncated p53) including PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5 and A375 with IC50 from 2.3 to 11 nM, respectively.YM155 increases the sensitivity of NSCLC cells to ¦Ã-radiation. The combination of YM155 and ¦Ã-radiation increases both the number of apoptotic cells and the activity of caspase-3. YM155 delays the repair of radiation-induced double-strand breaks in nuclear DNA.

prudect name : YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 ¦ÌM. YM155 significantly inhibits endogenous survivin expression in PC-3 and PPC-1 human HRPC…

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prudect name : YS-49Synonyms: CAS NO: 132836-42-1Molecular Formula: C20H20BrNO2Molecular Weight: 386.28Purity: 98% minSolubility: In DMSOStorage:

prudect name : YS-49 Synonyms: CAS NO: 132836-42-1Molecular Formula: C20H20BrNO2Molecular Weight: 386.28Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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YM201636 potently inhibits mammalian PIKfyve with an IC50 of 33 nM but not yeast orthologue Fab1 with an IC50 of >5 ¦ÌM, exhibiting around 100-fold selectivity for PtdIns3P p110¦Á with an IC50 of 3 ¦ÌM. YM201636 (0.8 ¦ÌM) significantly decreases the production of PtdIns(3,5)P2 by 80% in serum-starved NIH3T3 cells followed by serum stimulation with no effect on serum-stimulated protein kinase B (PKB) Ser 473 phosphorylation. YM-201636 reversibly impairs endosomal trafficking in NIH3T3 cells by blocking PIKfyve and PtdIns(3,5)P2 production, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 (0.8 ¦ÌM) also significantly reduces retroviruses budding from cells by 80%, apparently through interfering with the endosomal sorting complex required for transport (ESCRT) machinery.

prudect name : YM201636 potently inhibits mammalian PIKfyve with an IC50 of 33 nM but not yeast orthologue Fab1 with an IC50 of >5 ¦ÌM, exhibiting around 100-fold selectivity for…

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