VD/VDR-vd-vdr.com

For the treatment of chronic rheumatoid arthritis, deformation of arthritis, back pain, periarthritis of shoulder, neck and wrist surgery syndrome, post-traumatic pain and inflammation after tooth extraction

June 21, 2017

prudect name : For the treatment of chronic rheumatoid arthritis, deformation of arthritis, back pain, periarthritis of shoulder, neck and wrist surgery syndrome, post-traumatic pain and inflammation after tooth extractionZaltoprofen…

📌

0💬 read more

Zibotentan(ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). It was first evaluated as a potential treatment for pulmonary arterial hypertension in the late 1990s. Subsequently, interest switched to the role of endothelins in cancer, particularly hormone-resistant prostate cancer (HRPC). In vitro, Zibotentan(ZD4054) has been shown to compete with 125I-ET-1 for binding to the cloned human ETA-receptor with an IC50 value of 21 nM. No binding to the ETB receptor was observed with concentrations of zibotentan in excess of 10 ¦ÌM. This agent is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan(ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.

prudect name : Zibotentan(ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). It was first evaluated as a potential treatment for pulmonary…

📌

0💬 read more

prudect name : ZidovudineSynonyms: CAS NO: 30516-87-1Molecular Formula: C10H13N5O4Molecular Weight: 267.24Purity: 99% minSolubility: Storage: −20°C

prudect name : Zidovudine Synonyms: CAS NO: 30516-87-1Molecular Formula: C10H13N5O4Molecular Weight: 267.24Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

Zalcitabine is a nucleoside reverse transcriptase inhibitors

prudect name : Zalcitabine is a nucleoside reverse transcriptase inhibitorsZalcitabine Synonyms: CAS NO: 7481-89-2Molecular Formula: 7481–89–2 Molecular Weight: 211.22Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

(Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine

prudect name : (Z)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridineZ-JIB-04 (NSC 693627) Synonyms: CAS NO: 199596-24-2Molecular Formula: C17H13ClN4Molecular Weight: 308.1Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

📌

0💬 read more

ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3K¦Ä.

prudect name : ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3K¦Ä.ZSTK 474 Synonyms: CAS NO: 475110-96-4Molecular Formula: C19H21F2N7O2Molecular Weight: 417.41Purity: 98% minSolubility: in DMSOStorage: -20oC…

📌

0💬 read more

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 ¦ÌM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells

prudect name : Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 ¦ÌM)…

📌

0💬 read more

Synonyms:4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL;ZM 241385;4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol

prudect name : Synonyms:4-(2-[7-AMINO-2-(2-FURYL)[1,2,4]TRIAZOLO[2,3-A][1,3,5]TRIAZIN-5-YLAMINO]ETHYL)PHENOL;ZM 241385;4-(2-(7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenolZM 241385 Synonyms: CAS NO: 139180-30-6Molecular Formula: C16H15N7O2Molecular Weight: 337.34Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

A 179578; ABT 578; Resolute; 42-(1-Tetrazolyl)rapamycin; (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin

prudect name : A 179578; ABT 578; Resolute; 42-(1-Tetrazolyl)rapamycin; (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycinZotarolimus A179578 ABT 578 Synonyms: CAS NO: 221877-54-9Molecular Formula: C52H79N5O12Molecular Weight: 966.21Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38¦Á and SAPK2b/p38¦Â with IC50 of 2 ¦ÌM, and is selective over 17 other protein kinases including PKA, PKC, AMPK, p42 MAPK, MKK1, SAPK1/JNK, and CDK1 even at the concentration of up to 50 ¦ÌM. ZM 336372 does not prevent constitutive as well as growth factor or phorbol ester induced activation of MKKl or p42 MAPK/ERK2. Moreover, ZM 336372 dose not reverse the phenotype of Ras- or Raf-transformed cell lines. ZM 336372 treatment induces >100 activation of c-Raf and the B-Raf isoform, but it does not trigger any activation of MKKI or p42 MAPK/ERKP or induce any increase in the GTP-loading of Ras, suggesting that a feedback control loop exists by which Raf isoforms suppress their own activation, such that inhibition is always counterbalanced by reactivation. ZM 336372-induced activation of c-Raf is not prevented by inhibition of the MAPK cascade, protein kinase C or phosphatidylinositide 3-kinase.

prudect name : ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38¦Á and SAPK2b/p38¦Â with IC50 of 2 ¦ÌM, and is selective over 17 other protein kinases…

📌

0💬 read more