CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies.

 June 21, 2017

prudect name : CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the…

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Cerdulatinib(PRT-062070; PRT2070) is an novel oral dual Syk/JAK inhibitor.

prudect name : Cerdulatinib(PRT-062070; PRT2070) is an novel oral dual Syk/JAK inhibitor.Cerdulatinib (PRT062070, PRT2070) Synonyms: CAS NO: 1198300-79-6Molecular Formula: C20H27N7O3SMolecular Weight: 445.54Purity: 98% minSolubility: In DMSOStorage: -20 oC NND 502…

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Prasugrel(CAS NO:150322-43-3)intermediates

prudect name : Prasugrel(CAS NO:150322-43-3)intermediatesCyclopropyl 2-fluorobenzyl ketone Synonyms: CAS NO: 150322-73-9Molecular Formula: C11H11FOMolecular Weight: 178.20Purity: ≥98%Solubility: Storage: −20°C 2 years SP-2509 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/1850821

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Prasugrel(CAS NO:150322-43-3)intermediates

prudect name : Prasugrel(CAS NO:150322-43-3)intermediatesCylopropylcarbonyl-2-flurobenzyl bromide Synonyms: CAS NO: 204205-33-4Molecular Formula: C11H10BrFOMolecular Weight: 257.10Purity: ≥98%Solubility: Storage: −20°C 2 years AP23573 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508209

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CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro.CPI203 exerts a cytostatic effect in all the 9 MCL cell lines analyzed with GI50 ranging from 0.06 to 0.71 ยฆรŒM, with low cytotoxicity in normal PBMCs from healthy donors. Furthermore, lenalidomide and CPI203, by targeting IRF4 and MYC, efficiently activates the cell death program in MCL cells resistant to bortezomib

prudect name : CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro.CPI203 exerts a cytostatic effect in all the 9 MCL cell…

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Calcipotriene; (1R,3S,5Z)-5-[(2E)-2-[1-[(E,2R,5R)-5-Cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

prudect name : Calcipotriene; (1R,3S,5Z)-5-[(2E)-2-[1-[(E,2R,5R)-5-Cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diolCalcipotriol Synonyms: CAS NO: 112828-00-9Molecular Formula: C27H40O3Molecular Weight: C27H40O3Purity: 98% minSolubility: In DMSOStorage: -20 oC Sapanisertib References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508174

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Carminomycin I; ; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

prudect name : Carminomycin I; ; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside; (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosideCarubicin Synonyms: CAS NO: 50935-04-1Molecular Formula: C26H27NO10Molecular Weight: 513.49Purity: 98% minSolubility: In DMSOStorage: -20°C GSK-343 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508174

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prudect name : cis-JasmoneSynonyms: CAS NO: 488-10-8Molecular Formula: C11H16OMolecular Weight: 164.25Purity: ≥99%Solubility: Storage: −20°C

prudect name : cis-Jasmone Synonyms: CAS NO: 488-10-8Molecular Formula: C11H16OMolecular Weight: 164.25Purity: ≥99%Solubility: Storage: −20°C 2 years E 3810 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508169

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prudect name : CloprostenolSynonyms: CAS NO: 40665-92-7Molecular Formula: C22H29ClO6Molecular Weight: 424.92Purity: ≥99%Solubility: In DMSOStorage: −20°C

prudect name : Cloprostenol Synonyms: CAS NO: 40665-92-7Molecular Formula: C22H29ClO6Molecular Weight: 424.92Purity: ≥99%Solubility: In DMSOStorage: −20°C 2 years UK-427857 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508157

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CARIPORIDE;N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide

prudect name : CARIPORIDE;N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamideCariporide Synonyms: CAS NO: 159138-80-4Molecular Formula: C12H17N3O3SMolecular Weight: 283.35Purity: 98% minSolubility: Storage: -20°C LDK 378 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18508119

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