CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action is unknown, alpha-lipoic acid analogue CPI-613 has been shown to inhibit metabolic and regulatory processes required for cell growth in solid tumors. Both enantiomers in the racemic mixture exhibit antineoplastic activity.

 June 21, 2017

prudect name : CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action…

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Cidofovir(Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. (IC50= 0.94 ¦ÌM) A wild type HCMV laboratory strain (AD 169) and 3 ganciclovir-resistant clinical isolates(generated as a result of Ganciclovir therapy) that are cross-resistant to cidofovir were also included in the cidofovir susceptibility assays. AD 169 showed a cidofovir IC50 value of 0.6 pM, and the ganciclovir- resistant isolates showed cidofovir IC50 values ranging from 2.3 to 16 pM

prudect name : Cidofovir(Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. (IC50= 0.94 ¦ÌM) A wild type HCMV laboratory strain (AD 169) and 3 ganciclovir-resistant…

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Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B¡¯s RNA binding and hepatitis C virus (HCV) replication.

prudect name : Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B¡¯s RNA binding and hepatitis C virus (HCV) replication.Clemizole Synonyms: CAS…

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prudect name : CeftezoleSynonyms: CAS NO: 26973-24-0Molecular Formula: C13H12N8O4S3Molecular Weight: 440.48Purity: 98% minSolubility: Storage: −20°C

prudect name : Ceftezole Synonyms: CAS NO: 26973-24-0Molecular Formula: C13H12N8O4S3Molecular Weight: 440.48Purity: 98% minSolubility: Storage: −20°C EGF-816 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508782

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prudect name : Carboprost tromethamineSynonyms: CAS NO: 58551-69-2Molecular Formula: C21H36O5.C4H11NO3Molecular Weight: 489.64Purity: 99%Solubility: Storage: -20¡æ

prudect name : Carboprost tromethamine Synonyms: CAS NO: 58551-69-2Molecular Formula: C21H36O5.C4H11NO3Molecular Weight: 489.64Purity: 99%Solubility: Storage: -20¡æ XCT 790 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508759

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CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy.

prudect name : CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two…

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CAL-101 is a potent PI3K p110¦Ä inhibitor with an IC50 of 65 nM. CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis. CAL-101 has 40 to 300-fold selectivity compared to other PI3K isoforms. In vitro studies of 0.1 to 10 µM CAL-101 showed inhibition of pAKT expression and/or apoptotic effects against primary chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) cells and against a range of leukemia and lymphoma cell lines.

prudect name : CAL-101 is a potent PI3K p110¦Ä inhibitor with an IC50 of 65 nM. CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream…

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Canagliflozin is a novel C-glucoside with thiophene ring. Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 ¦ÌM and >1 ¦ÌM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 µM) or phlorizin (3 mM) alone in the presence of 50 µM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 µM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively.

prudect name : Canagliflozin is a novel C-glucoside with thiophene ring. Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with…

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prudect name : Cidofovir hydrateSynonyms: CAS NO: 149394-66-1Molecular Formula: C8H14N3O6P.2(H2O)Molecular Weight: 315.22Purity: 98% minSolubility: In

prudect name : Cidofovir hydrate Synonyms: CAS NO: 149394-66-1Molecular Formula: C8H14N3O6P.2(H2O)Molecular Weight: 315.22Purity: 98% minSolubility: In DMSOStorage: -20¡æ MELK inhibitor References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508602

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prudect name : CL-BKSynonyms: CAS NO: 178454-81-4Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20¡æ

prudect name : CL-BK Synonyms: CAS NO: 178454-81-4Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20¡æ Ataluren References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508584

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