paroxetine( antidepressant )intermediates

 June 21, 2017

prudect name : paroxetine( antidepressant )intermediatesN-Methylparoxetine Synonyms: CAS NO: 110429-36-2Molecular Formula: C20H22FNO3Molecular Weight: 343.39Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535026

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prudect name : N-Methyl-3-pyrrolidinyl cyclopentylmandelateSynonyms: CAS NO: 13118-11-1Molecular Formula: C18H25NO3Molecular Weight: 303.40Purity: 98% minSolubility: Storage:

prudect name : N-Methyl-3-pyrrolidinyl cyclopentylmandelate Synonyms: CAS NO: 13118-11-1Molecular Formula: C18H25NO3Molecular Weight: 303.40Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535024

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BIBF-1120 intermediates

prudect name : BIBF-1120 intermediatesN-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide Synonyms: CAS NO: 262368-30-9Molecular Formula: C14H22N4OMolecular Weight: 262.35Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535023

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Nilotinib is a inhibitor of BCR-ABL, IC50 < 30nM.

prudect name : Nilotinib is a inhibitor of BCR-ABL, IC50 < 30nM.Nilotinib Synonyms: CAS NO: 641571-10-0Molecular Formula: C28H22F3N7OMolecular Weight: 529.52Purity: 99%Solubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com References...

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NSC697923 is a selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A suggested to disrupt formation of the Ubc13~Ub conjugate. Shown to inhibit proliferation and survival of certain B-cell lymphoma cells.

prudect name : NSC697923 is a selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A suggested to disrupt formation of the Ubc13~Ub conjugate. Shown to inhibit proliferation and survival of…

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Imatinib(CAS NO:152459-95-5)Intermediates

prudect name : Imatinib(CAS NO:152459-95-5)IntermediatesN-(5-amino-2-methylphenl)-4-(3-pyridyl)-2-pyrimidine-amine Synonyms: CAS NO: 152460-10-1Molecular Formula: C16H15N5Molecular Weight: 277.32Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534960

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Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

prudect name : Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional…

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Nemorubicin(Methoxymorpholinyl doxorubicin; MMDX; PNU 152243) is a 3¡¯-deamino-3¡¯[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin, Nemorubici has the anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.

prudect name : Nemorubicin(Methoxymorpholinyl doxorubicin; MMDX; PNU 152243) is a 3¡¯-deamino-3¡¯[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin, Nemorubici has the anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.Nemorubicin Synonyms: CAS…

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N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide

prudect name : N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamideN-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide Synonyms: CAS NO: 1350920-22-7Molecular Formula: C22H25F3N2OMolecular Weight: 390.2Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534654

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BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells. For Class I PI3K family, NVP-BEZ235 biochemical IC50 are 4nM against p110¦Á,75nM against p110¦Â,7nM against p110¦Ò,5nM against p110¦Ã. Quantification of S473-Akt and T308P-Akt levels by ELISA revealed that 50% reduction occurred at a compound concentration of 8.0 nmol/L and 30 nmol/L.

prudect name : BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway…

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