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N,N¡¯-Propylenedinicotinamide

June 21, 2017

prudect name : N,N¡¯-PropylenedinicotinamideNicaraven Synonyms: CAS NO: 79455-30-4Molecular Formula: C15H16N4O2Molecular Weight: 284.31Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535554

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prudect name : N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamideSynonyms: CAS NO: 253168-86-4Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: Storage: -20

prudect name : N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Synonyms: CAS NO: 253168-86-4Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: Storage: -20 oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535548/

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Macitentan intermediates

prudect name : Macitentan intermediatesN-Propylsulfamide Synonyms: CAS NO: 147962-41-2Molecular Formula: C3H10N2O2SMolecular Weight: 138.19Purity: 98% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535548

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BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. BKM120 inhibits tumor proliferation and survival by blocking the phosphatidylinositol-3-kinase (PI3K) pathway. BKM120 has shown significant cell growth inhibition and induction of apoptosis in a variety of tumor cell lines as well as in animal models. BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

prudect name : BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. BKM120 inhibits tumor proliferation and survival by blocking the phosphatidylinositol-3-kinase (PI3K) pathway. BKM120…

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Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6 ¦ÌM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3K¦Ã is 0.12 ¦ÌM, 0.17 ¦ÌM, 1.1 ¦ÌM and 1.5 ¦ÌM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells.

prudect name : Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6…

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Genitourinary infection typhoid fever and other gastrointestinal infections such as Salmonella infection.

prudect name : Genitourinary infection typhoid fever and other gastrointestinal infections such as Salmonella infection.Norfloxacin Synonyms: CAS NO: 70458-96-7Molecular Formula: C16H18FN3O3Molecular Weight: 319.33Purity: 99%Solubility: Storage: −20°C 2 years web site:…

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Nimustine hydrochloride effects Indications: relieve the following symptoms and signs of illness: brain and neck cancer, brain tumors, lung cancer, gastrointestinal cancer (stomach, colon / rectal cancer, esophageal cancer), malignant lymphoma and leukemia.

prudect name : Nimustine hydrochloride effects Indications: relieve the following symptoms and signs of illness: brain and neck cancer, brain tumors, lung cancer, gastrointestinal cancer (stomach, colon / rectal cancer,…

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Saracatinib (AZD0530) intermediates

prudect name : Saracatinib (AZD0530) intermediatesN-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine Synonyms: CAS NO: 379230-38-3Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535128

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prudect name : NitrocaphanumSynonyms: CAS NO: 86010-32-4Molecular Formula: C9H4ClNO3SMolecular Weight: 241.65Purity: 99%Solubility: Storage: −20°C

prudect name : Nitrocaphanum Synonyms: CAS NO: 86010-32-4Molecular Formula: C9H4ClNO3SMolecular Weight: 241.65Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535027

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Saracatinib (AZD0530) intermediates.

prudect name : Saracatinib (AZD0530) intermediates.N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine hydrochloride Synonyms: CAS NO: 536740-46-2Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535026

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