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NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7¦ÌM, respectively. NVP-BHG712 inhibits multiple Eph receptor kinases. NVP-BHG712 inhibits VEGF driven angiogenesis. In a panel of more than 40 in vitro kinase assays, NVP-BHG712 showed excellent selectivity. Only c-raf, c-src and c-abl showed moderate inhibition as judged from our biochemical assays. In cell based assays ED50 for inhibition of EphB4 autophosphorylation was found to be 25 nM and thereby be roughly 200 fold more potent on EphB4 than on VEGFR2. NVP-BHG712 inhibited dose dependently VEGF stimulated tissue formation and vascularization in this model. Already at doses of daily 3 mg/kg p.o administration we observed signiﬁcant inhibition, and daily administration of 10 mg/kg/kg p.o. was sufﬁcient to reverse VEGF enhanced tissue formation and vessel growth

June 21, 2017

prudect name : NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7¦ÌM, respectively. NVP-BHG712 inhibits…

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Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.

prudect name : Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.Nexturastat A Synonyms: CAS NO: 1403783-31-2Molecular Formula: C19H23N3O3Molecular…

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17-phenyl trinor PGE2 serinol amide (17-phenyl trinor PGE2-SA) is a stable analog of PGE2 2-glyceryl ester that has been modified to increase receptor binding affinity. The biological activity of 17-phenyl trinor PGE2-SA has not yet been determined.

prudect name : 17-phenyl trinor PGE2 serinol amide (17-phenyl trinor PGE2-SA) is a stable analog of PGE2 2-glyceryl ester that has been modified to increase receptor binding affinity. The biological…

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Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

prudect name : Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.Naltrexone hydrochloride Synonyms: CAS NO: 16676-29-2Molecular Formula: C20H23NO4.HClMolecular Weight: 377.86Purity: 98%…

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NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

prudect name : NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.NMS-873 Synonyms: CAS NO: 1418013-75-8Molecular Formula: C27H28N4O3S2Molecular Weight: 520.67Purity: 98% minSolubility: In DMSOStorage: -20 oC…

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prudect name : Nepicastat hydrochloride RS 25560-197Synonyms: RS 25560-197CAS NO: 170151-24-3Molecular Formula: C14H15F2N3S.HClMolecular Weight:

prudect name : Nepicastat hydrochloride RS 25560-197 Synonyms: RS 25560-197CAS NO: 170151-24-3Molecular Formula: C14H15F2N3S.HClMolecular Weight: 331.81Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535736

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Lapatinib(CAS NO:231277-92-2)Intermediates

prudect name : Lapatinib(CAS NO:231277-92-2)IntermediatesN-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine Synonyms: CAS NO: 231278-20-9Molecular Formula: C21H14ClFIN3OMolecular Weight: 505.71Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535660

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Nilvadipine for light, moderate and severe hypertension treatment.

prudect name : Nilvadipine for light, moderate and severe hypertension treatment.Nilvadipine Synonyms: CAS NO: 75530-68-6Molecular Formula: C19H19N3O6Molecular Weight: 385.38Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535623

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Afatinib intermediates

prudect name : Afatinib intermediatesN-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine Synonyms: (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amineCAS NO: 162012-67-1Molecular Formula: C14H7ClF2N4O2Molecular Weight: 336.68Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535608

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prudect name : N-EthylmethylamineSynonyms: CAS NO: 624-78-2Molecular Formula: C3H9NMolecular Weight: 59.11Purity: 98% minSolubility: Storage: -20°C

prudect name : N-Ethylmethylamine Synonyms: CAS NO: 624-78-2Molecular Formula: C3H9NMolecular Weight: 59.11Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535601

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