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is important fine organic chemical intermediates, widely used in medicine, chemical industry and other fields.

June 21, 2017

prudect name : is important fine organic chemical intermediates, widely used in medicine, chemical industry and other fields.N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide Synonyms: 9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanineCAS NO: 3056-33-5Molecular Formula: C9H9N5O3Molecular Weight: 235.20Purity: ≥98%Solubility: Storage: −20°C 2…

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Vemurafenib intermediate

prudect name : Vemurafenib intermediateN-{3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-1-propanesulfonamide Synonyms: CAS NO: 918504-27-5Molecular Formula: C17H14BrF2N3O3SMolecular Weight: 458.28Purity: 98% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536712

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prudect name : NedocromilSynonyms: CAS NO: 69049-73-6Molecular Formula: C19H17NO7Molecular Weight: 371.35Purity: 98% minSolubility: In DMSOStorage:

prudect name : Nedocromil Synonyms: CAS NO: 69049-73-6Molecular Formula: C19H17NO7Molecular Weight: 371.35Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536657

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NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation.

prudect name : NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+…

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prudect name : NorgestrelSynonyms: CAS NO: 6533-00-2Molecular Formula: C21H28O2Molecular Weight: 312.45Purity: 98% minSolubility: Storage: −20°C

prudect name : Norgestrel Synonyms: CAS NO: 6533-00-2Molecular Formula: C21H28O2Molecular Weight: 312.45Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536531

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prudect name : N,N’-Bis(naphthalene-2-yl)-N,N’-bis(phenyl)benzidineSynonyms: ¦Á-NPBCAS NO: 139255-17-7Molecular Formula: C44H32N2Molecular Weight: 588.74Purity: 99% minSolubility: Storage:

prudect name : N,N’-Bis(naphthalene-2-yl)-N,N’-bis(phenyl)benzidine Synonyms: ¦Á-NPBCAS NO: 139255-17-7Molecular Formula: C44H32N2Molecular Weight: 588.74Purity: 99% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536375

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Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 ¦Ìmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

prudect name : Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 ¦Ìmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in…

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N6022 is a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clinical development for the treatment of acute asthma. GSNOR is a member of the alcohol dehydrogenase family (ADH) and regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). Reduced levels of GSNO, as well as other nitrosothiols (SNOs), have been implicated in the pathogenesis of many diseases including those of the respiratory, cardiovascular, and gastrointestinal systems. Preservation of endogenous SNOs through GSNOR inhibition presents a novel therapeutic approach with broad applicability. N6022 was demonstrated efficacy in a mouse ovalbumin (OVA) model of asthma.

prudect name : N6022 is a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clinical development for the treatment of acute asthma. GSNOR is a…

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N-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamide

prudect name : N-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamideN-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamide Synonyms: CAS NO: 1443139-14-7Molecular Formula: C19H17BrN2O2Molecular Weight: 384.0Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536238

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Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. This drug performed growth inhibitory activity (IC50 = 1.61 µM) against MOLT-4 cells

prudect name : Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in…

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