prudect name : NorgestimateSynonyms: CAS NO: 35189-28-7Molecular Formula: C23H31NO3Molecular Weight: 369.50Purity: 98% minSolubility: Storage: −20°C

 June 21, 2017

prudect name : Norgestimate Synonyms: CAS NO: 35189-28-7Molecular Formula: C23H31NO3Molecular Weight: 369.50Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537400

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NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 ¦ÌM. NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor and other tyrosine kinases. In a panel of 10 neuroblastoma cell lines positive for IGF-IR expression, NVP-AEW541 inhibited in vitro proliferation in a submicromolar/micromolar (0.4-6.8) range of concentrations. NVP-AEW541 inhibits IGF-I-mediated receptor activation and downstream signaling. In addition to growth inhibition, NVP-AEW541 also induced apoptosis in vitro. Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice. Therapeutic potential of NVP-AEW541 was also analyzed in Ewing¡¯s sarcoma, osteosarcoma, rhabdomyosarcoma, and pancreatic cancer.

prudect name : NVP-AEW541 is an IGF-IR inhibitor with an IC50 of median 3.6 ¦ÌM. NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative highly selective against IGF-IR, compared with the insulin receptor and…

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sofobuvir intermediates

prudect name : sofobuvir intermediatesN-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl ester Synonyms: CAS NO: 1256490-31-9Molecular Formula: C18H21N2O7PMolecular Weight: 408.34Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537182

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BGJ398 is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.

prudect name : BGJ398 is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities….

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NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 ¦ÌM for DNA-PK, mTOR and PI 3-K, respectively. NU7441 has less inhibitory activity against ATM and ATR (IC50 valuse>100 ¦ÌM). NU7441 increased the cytotoxicity of IR and etoposide in V3-YAC cells but not in V3 cells, confirming that DNA-PKcs is the cellular target of NU7441. NU7441 alone had no effect on cell cycle distribution, but accumulation in G2/M induced by exposure to IR (2 Gy) or the topoisomerase II poisons, doxorubicin (10 nM) or etoposide (0.1 µM) was increased 1.2 to 2 fold by NU7441 in SW620 cells.

prudect name : NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 ¦ÌM for DNA-PK, mTOR and PI 3-K, respectively. NU7441…

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NVP-BGT226 has entered phase I/II clinical trials for the treatment of advanced solid tumors (including breast cancer).

prudect name : NVP-BGT226 has entered phase I/II clinical trials for the treatment of advanced solid tumors (including breast cancer).NVP-BGT226 Synonyms: CAS NO: 1245537-68-1Molecular Formula: C28H25F3N6O2.C4H4O4Molecular Weight: 650.6Purity: 98% minSolubility:…

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prudect name : NorethindroneSynonyms: CAS NO: 68-22-4Molecular Formula: C20H26O2Molecular Weight: 298.42Purity: 99% minSolubility: Storage: −20°C

prudect name : Norethindrone Synonyms: CAS NO: 68-22-4Molecular Formula: C20H26O2Molecular Weight: 298.42Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536938

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NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972 also suppresses constitutive MET phosphorylation in GTL-16 cells or HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 nM and 22 nM, respectively. NVP-BVU972 potently prevents the growth of the MET gene amplified cell linse GTL-16, MKN-45 and EBC-1 with IC50 values of 66 nM, 82 nM and 32 nM, respectively. In line with their high frequency in the NVP-BVU972 screen, Y1230 and D1228 mutations give rise to dramatic shifts in the measured IC50 values for NVP-BVU972 in BaF3 cell line. Resistance triggered by V1155L is more limited to NVP-BVU972.A dose-dependent reduction in TPR-MET phosphorylation when applying NVP-BVU972 to BaF3 cells expressing wild-type TPR-MET. Both Y1230H and D1228A mutations abrogated the effect of NVP-BVU972. However, F1200I and L1195V interferes with the potency of NVP-BVU972 to prevent TPR-MET phosphorylation.

prudect name : NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM….

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MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

prudect name : MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against…

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prudect name : NSC-339555;BRYOSTATIN;BRYOSTATIN 1Synonyms: CAS NO: 83314-01-6Molecular Formula: C47H68O17Molecular Weight: 905.03Purity: 98% minSolubility: Storage:

prudect name : NSC-339555;BRYOSTATIN;BRYOSTATIN 1 Synonyms: CAS NO: 83314-01-6Molecular Formula: C47H68O17Molecular Weight: 905.03Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536718

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