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prudect name : Oestradiol 17-heptanoateSynonyms: CAS NO: 4956-37-0Molecular Formula: C25H36O3Molecular Weight: 384.55Purity: 98% minSolubility: Storage:

June 21, 2017

prudect name : Oestradiol 17-heptanoate Synonyms: CAS NO: 4956-37-0Molecular Formula: C25H36O3Molecular Weight: 384.55Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1853790

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Olmetec; CS-866; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2¡¯-(1H-tetazol-5-yl)[1,1¡¯-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

prudect name : Olmetec; CS-866; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2¡¯-(1H-tetazol-5-yl)[1,1¡¯-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl esterOlmesartan medoxomil Synonyms: CAS NO: 144689-63-4Molecular Formula: C29H30N6O6Molecular Weight: 558.59Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537880

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Obatoclax is Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L)

prudect name : Obatoclax is Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L)Obatoclax Mesylate;…

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OSI027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor. OSI027 has potential antineoplastic activity. MTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. MTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. OSI027 acts as a potent suppressor of primitive leukemic precursors. OSI027 much more effective than rapamycin in eliciting antileukemic effects in vitro. OSI027 induces apoptosis of different types of cells transformed by the T315I-BCR-ABL mutation, which confers resistance to imatinib mesylate, nilotinib, and dasatinib

prudect name : OSI027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor. OSI027 has potential antineoplastic activity. MTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR…

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Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.Rigosertib is non-ATP-competitive inhibitor to PLK1 with IC50 of 9 nM. Rigosertib also exhibits inhibition against PLK2, PDGFR, Flt1, BCR-ABL, Fyn, Src, and CDK1, with IC50 of 18-260 nM. Rigosertib shows cell killing activity against 94 different tumor cell lines with IC50 of 50-250 nM, including BT27, MCF-7, DU145, PC3, U87, A549, H187, RF1, HCT15, SW480, and KB cells. While in normal cells, such as HFL, PrEC, HMEC, and HUVEC, Rigosertib has little or no effect unless its concentration is greater than 5-10 ¦ÌM. In HeLa cells, Rigosertib (100-250 nM) induces spindle abnormalities and apoptosis.

prudect name : Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.Rigosertib…

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OSI-930 is a multi-targeted tyrosine kinase inhibitor that is designed to act as a potent co-inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).OSI-930 targets both cancer cell proliferation and blood vessel growth (angiogenesis) in selected tumors. In preclinical studies, OSI-930 shows broad efficacy in tumor models representative of small cell lung cancer, glioblastoma, colorectal, renal, head and neck, non-small cell lung cancer and gastric cancers.

prudect name : OSI-930 is a multi-targeted tyrosine kinase inhibitor that is designed to act as a potent co-inhibitor of the receptor tyrosine kinases c-Kit (IC50:9.5nM) and VEGFR-2 (IC50:10.1nM).OSI-930 targets…

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8-Cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile

prudect name : 8-Cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrileON123300 Synonyms: CAS NO: 1357470-29-1Molecular Formula: C24H27N7OMolecular Weight: 429.52Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537830

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Oxymatrine a role in anti-hepatitis B virus, hepatitis B virus can reduce the liver of transgenic mice the content of HBsAg and HBcAg.

prudect name : Oxymatrine a role in anti-hepatitis B virus, hepatitis B virus can reduce the liver of transgenic mice the content of HBsAg and HBcAg.oxymatrine Synonyms: CAS NO: 16837-52-8Molecular…

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Ostarine (GTx-024, MK-2866), a non-steroidal agent, is selective androgen receptor modulator (SARM) with anabolic activity. This agent is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone¡¯s action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia. Ostarine has demonstrated promising results in Phase I and II clinical trials.

prudect name : Ostarine (GTx-024, MK-2866), a non-steroidal agent, is selective androgen receptor modulator (SARM) with anabolic activity. This agent is designed to work like testosterone, thus promoting and/or maintaining…

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Spiro[3H-indole-3,1¡¯-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7¡¯-dichloro-6¡¯-fluoro-2¡¯,3¡¯,4¡¯,9¡¯-tetrahydro-3¡¯-methyl-, (1¡¯R,3¡¯S)-

prudect name : Spiro[3H-indole-3,1¡¯-[1H]pyrido[3,4-b]indol]-2(1H)-one, 5,7¡¯-dichloro-6¡¯-fluoro-2¡¯,3¡¯,4¡¯,9¡¯-tetrahydro-3¡¯-methyl-, (1¡¯R,3¡¯S)-NITD 609 Synonyms: CAS NO: 1193314-23-6Molecular Formula: C19H14Cl2FN3OMolecular Weight: Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537723

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