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Olanzapine is an atypical antipsychotic drug for the treatment of positive symptoms of schizophrenia, but also some effect on negative symptoms.

June 21, 2017

prudect name : Olanzapine is an atypical antipsychotic drug for the treatment of positive symptoms of schizophrenia, but also some effect on negative symptoms.Olanzapine Synonyms: CAS NO: 132539-06-1Molecular Formula: C17H20N4SMolecular…

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OC000459 is a once-daily oral CRTH2 antagonist in Phase IIb clinical trials that has demonstrated efficacy in asthma, allergic rhinitis and allergic conjunctivitis along with an excellent safety profile.

prudect name : OC000459 is a once-daily oral CRTH2 antagonist in Phase IIb clinical trials that has demonstrated efficacy in asthma, allergic rhinitis and allergic conjunctivitis along with an excellent…

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prudect name : OzagrelSynonyms: CAS NO: 82571-53-7Molecular Formula: C13H12N2O2Molecular Weight: 228.25Purity: 99%Solubility: Storage: −20°C 2

prudect name : Ozagrel Synonyms: CAS NO: 82571-53-7Molecular Formula: C13H12N2O2Molecular Weight: 228.25Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538524

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prudect name : Oclacitinib PF-03394197Synonyms: CAS NO: 1208319-26-9Molecular Formula: C15H23N5O2S Molecular Weight: 337.44 Purity: 98%

prudect name : Oclacitinib PF-03394197 Synonyms: CAS NO: 1208319-26-9Molecular Formula: C15H23N5O2S Molecular Weight: 337.44 Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538505

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prudect name : oritavancin,LY333328 phosphate saltSynonyms: CAS NO: 171099-57-3 192564-14-0(phosphate salt)Molecular Formula: C86H97Cl3N10O26Molecular Weight: 1793.115Purity:

prudect name : oritavancin,LY333328 phosphate salt Synonyms: CAS NO: 171099-57-3 192564-14-0(phosphate salt)Molecular Formula: C86H97Cl3N10O26Molecular Weight: 1793.115Purity: 95% minSolubility: in DMSOStorage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538407

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1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone

prudect name : 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanoneOTSSP167 Synonyms: CAS NO: 1431697-89-0Molecular Formula: C25H28Cl2N4O2Molecular Weight: 487.42Purity: 98% minSolubility: In DMSOStorage: -20 oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538404

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Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

prudect name : Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a…

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OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM); however, it lacks COX-2 inhibitory activity. It potently induces apoptosis in several types of cancer cells.The mechanism is mediated, at least in part, through the inhibition of phosphoinositide-dependent kinase-1 (PDK-1), an upstream kinase that phosphorylates AKT.OSU-03012 inhibited cell proliferation more effectively in both VS (IC50=3.1 ¦ÌM ) and HMS-97 (IC50=2.6 ¦ÌM )cells than in normal human Schwann cells(IC50=12 ¦ÌM ). OSU-03012 was well tolerated and inhibited the growth of HMS-97 schwannoma xenografts by 55% after 9 weeks of oral treatment. The anti-tumour activity correlated with reduced AKT phosphorylation

prudect name : OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM); however, it lacks COX-2 inhibitory activity. It potently induces apoptosis in several types…

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Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80% proteasome inhibition in most tissues and elicited an antitumor response in multiple human tumor xenograft and mouse syngeneic models

prudect name : Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80%…

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ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.

prudect name : ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.ODM-201 Synonyms: CAS NO: 1297538-32-9Molecular…

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