ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-K¦Á, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).

 June 21, 2017

prudect name : ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-K¦Á, and ATM (IC50= 0.6, 14, 36, 170, and…

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lagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).

prudect name : lagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).Elagolix Synonyms: CAS NO: 834153-87-6Molecular Formula: C32H30F5N3O5Molecular Weight:…

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Enasidenib is a oral potent, selective, reversible inhibitor of mutant IDH2.

prudect name : Enasidenib is a oral potent, selective, reversible inhibitor of mutant IDH2.Enasidenib Synonyms: CAS NO: 1446502-11-9Molecular Formula: C19H17F6N7OMolecular Weight: 473.38Purity: 98% minSolubility: DMSOStorage: -20¡æ SU-5416 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511798

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prudect name : Exenatide acetateSynonyms: CAS NO: 141732-76-5Molecular Formula: C184H282N50O60S.C2H4O2Molecular Weight: 4262.67Purity: 98% minSolubility: Storage:

prudect name : Exenatide acetate Synonyms: CAS NO: 141732-76-5Molecular Formula: C184H282N50O60S.C2H4O2Molecular Weight: 4262.67Purity: 98% minSolubility: Storage: -20°C JNJ 28431754 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511765

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Enoxacin is a third generation fluoroquinolone antibiotic with broad-spectrum, potent bactericidal effect.

prudect name : Enoxacin is a third generation fluoroquinolone antibiotic with broad-spectrum, potent bactericidal effect.Enoxacin Synonyms: CAS NO: 74011-58-8Molecular Formula: C15H17FN4O3Molecular Weight: 320.32Purity: ≥99%Solubility: Storage: −20°C 2 years BKM120 References…

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Gefitinib(CAS NO:184475-35-2)Intermediates

prudect name : Gefitinib(CAS NO:184475-35-2)IntermediatesETHYL 2-AMINO-4,5-DIMETHOXYBENZOATE Synonyms: CAS NO: 20323-74-4Molecular Formula: C11H15NO4Molecular Weight: 225.24Purity: ≥98%Solubility: Storage: −20°C 2 years MK0974 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511753

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DY131, a selective ERR¦Ã agonist, could potentiate the ERR¦Ã-induced growth inhibition in LNCaP- ERR¦Ã and DU145- ERR¦Ã cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ER¦Á-positive endometrial cancer cells but promoted that of the ER¦Á-negative cancer cells. DY131 had no effect on the structurally related receptors ERR¦Á or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.

prudect name : DY131, a selective ERR¦Ã agonist, could potentiate the ERR¦Ã-induced growth inhibition in LNCaP- ERR¦Ã and DU145- ERR¦Ã cells in a dose-dependent manner compared with respective parental cells….

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Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1¦Á prolyl hydroxylase).

prudect name : Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1¦Á prolyl hydroxylase).Dimethyloxaloylglycine (DMOG) Synonyms: CAS NO: 89464-63-1Molecular Formula: C6H9NO5Molecular Weight: 175.14Purity: 98% minSolubility: Storage: -20oC FG4592 References…

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DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).

prudect name : DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).DDR1-IN-1 Synonyms: CAS…

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Dapagliflozin(BMS-512148) is a potent sodium-glucose transport proteins inhibitor with IC50 of 1.1 nM and 1.4uM for SGLT2 and SGLT1, respectively. Dapagliflozin (BMS-512148) inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Symptoms of hypoglycaemia occurred in similar proportions of patients in the dapagliflozin (2~4%) and placebo groups (3%). Signs, symptoms, and other reports suggestive of genital infections were more frequent in the dapagliflozin groups (2•5 mg, [8%]; 5 mg, [13%]; 10 mg, [9%]) than in the placebo group ( [5%]).

prudect name : Dapagliflozin(BMS-512148) is a potent sodium-glucose transport proteins inhibitor with IC50 of 1.1 nM and 1.4uM for SGLT2 and SGLT1, respectively. Dapagliflozin (BMS-512148) inhibits subtype 2 of the…

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