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3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-propanenitrile

June 21, 2017

prudect name : 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]-propanenitrilePF-04880594 Synonyms: CAS NO: 1111636-35-1Molecular Formula: C19H16F2N8Molecular Weight: 394.38Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538797

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prudect name : PFI-2Synonyms: CAS NO: 1627676-59-8Molecular Formula: C23H25F4N3O3SMolecular Weight: 499.52Purity: 98% minSolubility: in DMSOStorage:

prudect name : PFI-2 Synonyms: CAS NO: 1627676-59-8Molecular Formula: C23H25F4N3O3SMolecular Weight: 499.52Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538790

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Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-

prudect name : Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-P5091 (P005091) Synonyms: CAS NO: 882257-11-6Molecular Formula: C12H7Cl2NO3S2Molecular Weight: 348.22Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538789

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prudect name : Polymyxin B sulfateSynonyms: CAS NO: 1405-20-5Molecular Formula: C56H98N16O13.H2SO4Molecular Weight: 1301.56Purity: Solubility: Storage:

prudect name : Polymyxin B sulfate Synonyms: CAS NO: 1405-20-5Molecular Formula: C56H98N16O13.H2SO4Molecular Weight: 1301.56Purity: Solubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538777

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PD0325901 is non-competitive with ATP and is exquisitely specific and highly potent against purified MEK, exhibiting a Kiapp of 1 nM against activated MEK1 and MEK2. PD0325901 is roughly 500-fold more potent than CI-1040 with respect to its cellular effects on phosphorylation of ERK1 and ERK2, exhibiting subnanomolar activity. A single oral dose of PD0325901 (25 mg/kg) suppressed phosphorylation of ERK by >50% at 24 hours post-dosing. Anticancer activity of PD 0325901 has been demonstrated for a broad spectrum of human tumor xenografts, significantly inhibiting the growth of 6 out of 7 human tumor models tested

prudect name : PD0325901 is non-competitive with ATP and is exquisitely specific and highly potent against purified MEK, exhibiting a Kiapp of 1 nM against activated MEK1 and MEK2. PD0325901…

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AXL1717 (Picropodophyllotoxin) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM; exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.

prudect name : AXL1717 (Picropodophyllotoxin) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM; exhibits little effect towards IR, FGFR, PDGFR and EGFR, and…

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PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity at E2.

prudect name : PYR-41 is a specific and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 uM, with no or little activity at E2.PYR-41 Synonyms:...

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OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays

prudect name : OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assaysOTX015 Synonyms: CAS NO: 202590-98-5Molecular…

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Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene; (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

prudect name : Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene; (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolideOleandrin Synonyms: CAS NO: 465-16-7Molecular Formula: C32H48O9Molecular Weight: 576.72Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538731

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Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens.

prudect name : Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a…

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