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PluriSln 1 is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. in vitro: Cellular and molecular analyses demonstrated that the most selective compound, PluriSIn 1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs. Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. PluriSIn 1 was also cytotoxic to mouse blastocysts, indicating that the dependence on oleate is inherent to the pluripotent state. Finally, application of PluriSIn 1 prevented teratoma formation from tumorigenic undifferentiated cells

June 21, 2017

prudect name : PluriSln 1 is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. in vitro:…

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Paritaprevir is an acylsulfonamide inhibitor of the NS3-4A serine protease that shows promising results as a treatment of hepatitis C.

prudect name : Paritaprevir is an acylsulfonamide inhibitor of the NS3-4A serine protease that shows promising results as a treatment of hepatitis C.Paritaprevir;ABT-450;ABT 450 Synonyms: CAS NO: 1216941-48-8Molecular Formula: C40H43N7O7SMolecular…

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Pomalidomide inhibits LPS-induced TNF-_alpha_ release with IC50 of 13 nM.

prudect name : Pomalidomide inhibits LPS-induced TNF-_alpha_ release with IC50 of 13 nM.Pomalidomide Synonyms: CAS NO: 19171-19-8Molecular Formula: C13H11N3O4Molecular Weight: 273.24Purity: 98% minSolubility: In DMSOStorage: -20 oC web site: www.medchemexpress.com

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PNU120596 is a potent and selective positive allosteric ¦Á7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 ¦ÌM. PNU120596 (PNU 120596, PNU-120596) has no detectable effect on ¦Á4¦Â2, ¦Á3¦Â4 and ¦Á9¦Á10 receptors. Discovered in a high-throughput screen, PNU120596 (PNU 120596, PNU-120596) enhanced agonist-evoked calcium flux mediated by an engineered variant of the human ¦Á7 nAChR. Electrophysiology studies demonstrated that PNU120596 (PNU 120596, PNU-120596) increased peak agonist-evoked currents mediated by wild-type receptors and also proved a pronounced prolongation of the triggered response in the continued presence of agonist.

prudect name : PNU120596 is a potent and selective positive allosteric ¦Á7 neuronal nicotinic acetylcholine receptors modulator with an EC50 of 0.2 ¦ÌM. PNU120596 (PNU 120596, PNU-120596) has no detectable…

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prudect name : PentostatinSynonyms: CAS NO: 53910-25-1Molecular Formula: C11H16N4O4Molecular Weight: 268.27Purity: 98% minSolubility: In DMSOStorage:

prudect name : Pentostatin Synonyms: CAS NO: 53910-25-1Molecular Formula: C11H16N4O4Molecular Weight: 268.27Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 ¦ÌM.

prudect name : Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 ¦ÌM.Pimobendan Synonyms: CAS NO: 74150-27-9Molecular Formula: C19H18N4O2Molecular Weight: 334.37Purity: 98% minSolubility: In DMSOStorage: -20 oC web…

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prudect name : Prostacyclin sodium saltSynonyms: CAS NO: 61849-14-7Molecular Formula: C20H31O5.NaMolecular Weight: 374.45Purity: 99%Solubility: Storage:

prudect name : Prostacyclin sodium salt Synonyms: CAS NO: 61849-14-7Molecular Formula: C20H31O5.NaMolecular Weight: 374.45Purity: 99%Solubility: Storage: -20¡æ web site: www.medchemexpress.com

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PCI-24781 (CRA-024781) is a novel broad spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) that shows antitumor activity in vitro and in vivo preclinically and is under evaluation in phase I clinical trials for cancer.PCI-24781 inhibited pure recombinant HDAC1 with a Ki of 0.007 Mmol/L, and also inhibited the other HDAC isozymes HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range.

prudect name : PCI-24781 (CRA-024781) is a novel broad spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) that shows antitumor activity in vitro and in vivo preclinically and is under…

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PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.

prudect name : PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.PJ 34 hydrochloride Synonyms:…

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PIK-294 is a highly selective p110¦Ä inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3K¦Á/¦Â/¦Ã, respectively.

prudect name : PIK-294 is a highly selective p110¦Ä inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3K¦Á/¦Â/¦Ã, respectively.PIK-294 Synonyms: CAS NO: 900185-02-6Molecular Formula: C28H23N7O2Molecular…

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