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prudect name : RoMidepsin Depsipeptide(FK-228,NSC-63017)Synonyms: RoMidepsin Depsipeptide(FK-228,NSC-63017)CAS NO: 128517-07-7Molecular Formula: C24H36N4O6S2Molecular Weight: 540.70Purity: 98% minSolubility:

June 21, 2017

prudect name : RoMidepsin Depsipeptide(FK-228,NSC-63017) Synonyms: RoMidepsin Depsipeptide(FK-228,NSC-63017)CAS NO: 128517-07-7Molecular Formula: C24H36N4O6S2Molecular Weight: 540.70Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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Ro 61-8048 is a potent and selective inhibitors of kynurenine hydroxylase with IC50 of 37 nM.

prudect name : Ro 61-8048 is a potent and selective inhibitors of kynurenine hydroxylase with IC50 of 37 nM.Ro 61-8048 Synonyms: CAS NO: 199666-03-0Molecular Formula: C17H15N3O6S2Molecular Weight: 421.45Purity: 98% minSolubility:…

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Rebamipide of gastritis, gastric ulcer has a good effect, but also can reduce the NSAIDs, Helicobacter pylori induced gastric mucosal injury.

prudect name : Rebamipide of gastritis, gastric ulcer has a good effect, but also can reduce the NSAIDs, Helicobacter pylori induced gastric mucosal injury.Rebamipide Synonyms: CAS NO: 111911-87-6Molecular Formula: C19H15ClN2O4Molecular…

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Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.

prudect name : Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT in cell-free assays, respectively. Phase 2.Rociletinib…

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Rifabutin(Mycobutin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription

prudect name : Rifabutin(Mycobutin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition…

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Repaglinide for diet and exercise can not effectively control high blood sugar in type 2 diabetes (non-insulin-dependent) patients.

prudect name : Repaglinide for diet and exercise can not effectively control high blood sugar in type 2 diabetes (non-insulin-dependent) patients.Repaglinide Synonyms: CAS NO: 135062-02-1Molecular Formula: C27H36N2O4Molecular Weight: 452.59Purity: ≥99%Solubility:…

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Retigabine is shown to be active against electrically induced seizures and against chemical seizures induced by pentylenetetrazole, picrotoxin and NMDA in mice. ED50 of Retigabine for them ranges from 4.0 to18.6 mg/kg (i.p.).In the full amygdala-kindling model of complex partial seizures in rats, Retigabine, at 0.01 mg/kg to 5 mg/kg, i.p., has been reported to dose dependently increase the threshold current for induction of after discharges. Following stimulation with the after discharge threshold current, Retigabine (5 mg/kg, i.p.) also reduces other seizure measures including seizure severity, seizure duration, total duration of behavioral changes and of changes after discharge.

prudect name : Retigabine is shown to be active against electrically induced seizures and against chemical seizures induced by pentylenetetrazole, picrotoxin and NMDA in mice. ED50 of Retigabine for them…

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Rocilinostat, previously known as ACY-1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.

prudect name : Rocilinostat, previously known as ACY-1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6,…

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Raltegravir is a novel HIV-1 integrase strand transfer inhibitor with potent in vitro activity against wild-type and multi-class resistant HIV-1 virus (in vitro IC95 for HIV-1 in 50% normal human serum = 33 nM). Inhibition of integrase prevents insertion of HIV DNA into the human DNA genome, thus blocking the ability of HIV to replicate. Raltegravir is administered orally every 12h and does not require boosting with low-dose ritonavir (RTV) to achieve therapeutic concentrations. Raltegravir is not a potent inhibitor or inducer of cytochrome P450 3A4, and it is predominantly metabolized by glucuronidation, specifically by the enzyme UDP-glucuronosyltransferase 1A1

prudect name : Raltegravir is a novel HIV-1 integrase strand transfer inhibitor with potent in vitro activity against wild-type and multi-class resistant HIV-1 virus (in vitro IC95 for HIV-1 in…

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Biological Activity Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

prudect name : Biological Activity Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing…

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