RN486 is a Bruton¡¯s tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fc¦Å receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fc¦Ã receptor engagement-mediated tumor necrosis factor ¦Á production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM).

 June 21, 2017

prudect name : RN486 is a Bruton¡¯s tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays…

📌
0💬 read more

Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.

prudect name : Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth…

📌
0💬 read more

prudect name : Raltegravir potassiumSynonyms: CAS NO: 871038-72-1Molecular Formula: C20H20FKN6O5Molecular Weight: 482.51Purity: 99%Solubility: Storage: −20°C

prudect name : Raltegravir potassium Synonyms: CAS NO: 871038-72-1Molecular Formula: C20H20FKN6O5Molecular Weight: 482.51Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

📌
0💬 read more

prudect name : RamiprilSynonyms: CAS NO: 87333-19-5Molecular Formula: C23H32N2O5Molecular Weight: 416.52Purity: ≥99%Solubility: Storage: −20°C

prudect name : Ramipril Synonyms: CAS NO: 87333-19-5Molecular Formula: C23H32N2O5Molecular Weight: 416.52Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

📌
0💬 read more

Remodelin is a potent acetyl-transferase NAT10 inhibitor.Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases

prudect name : Remodelin is a potent acetyl-transferase NAT10 inhibitor.Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and…

📌
0💬 read more

prudect name : R-428Synonyms: R428CAS NO: 1037624-75-1Molecular Formula: C30H34N8Molecular Weight: 506.64Purity: 98% minSolubility: In DMSOStorage:

prudect name : R-428 Synonyms: R428CAS NO: 1037624-75-1Molecular Formula: C30H34N8Molecular Weight: 506.64Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

📌
0💬 read more

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

prudect name : RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).RO8994…

📌
0💬 read more

rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL.

prudect name : rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited…

📌
0💬 read more

Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine; MT500

prudect name : Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine; MT500RS127445 Synonyms: CAS NO: 199864-87-4Molecular Formula: C17H16FN3Molecular Weight: 281.33Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

📌
0💬 read more

1-(morpholinoethyl)-4-nitroimidazole; 4-[2-(4-nitro-imidazol-1-yl)-ethyl]-morpholine; N-(Î2-Morpholinoethyl)-4-nitroimidazol; 1-(2-Morpholinoethyl)-4-nitroimidazol

prudect name : 1-(morpholinoethyl)-4-nitroimidazole; 4-[2-(4-nitro-imidazol-1-yl)-ethyl]-morpholine; N-(Î2-Morpholinoethyl)-4-nitroimidazol; 1-(2-Morpholinoethyl)-4-nitroimidazolRGW 611 Synonyms: CAS NO: 6497-78-5Molecular Formula: C9H14N4O3Molecular Weight: 226.24Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

📌
0💬 read more
« Previous
1 … 635 636 637 638 639 … 824
Next »