Regadenoson (CVT-3146) is an A2A adenosine receptor agonist that is a coronary vasodilator. It produces maximal hyperemia quickly and maintains it for an optimal duration that is practical for radionuclide myocardial perfusion imaging.

 June 21, 2017

prudect name : Regadenoson (CVT-3146) is an A2A adenosine receptor agonist that is a coronary vasodilator. It produces maximal hyperemia quickly and maintains it for an optimal duration that is…

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RKI-1447 is a cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting Rho Kinase inhibitor, displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%, 61.9%, 56.0%, and 50.4% inhibition, respectively, by 1 ¦ÌM RKI-1447) or 15 other kinases. Crystal structures of the RKI-1447/ROCK1 complex reveals that RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppresses phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but had no effect on the phosphorylation levels of the AKT, MEK, and S6 kinase at concentrations as high as 10 ¦ÌM. RKI-1447 is also highly selective at inhibiting ROCK-mediated cytoskeleton re-organization (actin stress fiber formation) following LPA stimulation, but does not affect PAK-meditated lamellipodia and filopodia formation following PDGF and Bradykinin stimulation. RKI-1447 inhibits migration, invasion and anchorage-independent tumor growth of breast cancer cells.

prudect name : RKI-1447 is a cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting Rho Kinase inhibitor, displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%,…

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R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM. R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways. Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models.

prudect name : R406 is an orally available spleen tyrosine kinase inhibitor with a Ki of 30 nM. R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation…

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prudect name : ResveratrolSynonyms: CAS NO: 501-36-0Molecular Formula: C14H12O3Molecular Weight: 228.24Purity: 99% minSolubility: Storage: −20°C

prudect name : Resveratrol Synonyms: CAS NO: 501-36-0Molecular Formula: C14H12O3Molecular Weight: 228.24Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com

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RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 ¦ÌM and no effective inhibition of any other HDAC at concentrations up to 15 ¦ÌM.

prudect name : RGFP966 is specific inhibitor of HDAC3, with an IC50 of 0.08 ¦ÌM and no effective inhibition of any other HDAC at concentrations up to 15 ¦ÌM.RGFP 966…

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Roflumilast displays anti-inflammatory and immunomodulatory in vitro. Roflumilast inhibits LTB4 synthesis in human neutrophil with IC50 of 2 nM. Roflumilast inhibits fMLP-stimulated ROS formation as luminol-enhanced CL in human neutrophils or eosinophils with IC35 of 4 nM, and 7 nM, repectively. Roflumilast inhibits LPS-stimulated TNF-¦Á synthesis in monocytes with IC40 of 21 nM. Roflumilast inhibits TNF-¦Á synthesis in monocyte-derived dendritic cells with IC20 of 5 nM. Rolfumilast inhibits anti-CD3 and anti-CD28 antibody-stimulated proliferation of CD4+ T cells with IC30 of 7 nM. Rolfumilast inhibits anti-CD3 and anti-CD28 antibody-stimulated synthesis of IL-2, IL-4, IL-5, and IFN-v in CD4+ T cells with IC20 of 1 nM, IC30 of 7 nM, IC25 of 13 nM, and IC35 of 8 nM, respectively

prudect name : Roflumilast displays anti-inflammatory and immunomodulatory in vitro. Roflumilast inhibits LTB4 synthesis in human neutrophil with IC50 of 2 nM. Roflumilast inhibits fMLP-stimulated ROS formation as luminol-enhanced CL…

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Rostafuroxin(PST 2238) is a antihypertensive compound; Na,K-ATPase antognist;displaced [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM.

prudect name : Rostafuroxin(PST 2238) is a antihypertensive compound; Na,K-ATPase antognist;displaced [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM.Rostafuroxin£»PST2238 Synonyms: CAS NO: 156722-18-8Molecular Formula: C23H34O4Molecular Weight: 374.51Purity: 98%…

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prudect name : Rebeprazole sodiumSynonyms: CAS NO: 117976-90-6Molecular Formula: C18H20N3NaO3SMolecular Weight: 381.43Purity: 98% minSolubility: In

prudect name : Rebeprazole sodium Synonyms: CAS NO: 117976-90-6Molecular Formula: C18H20N3NaO3SMolecular Weight: 381.43Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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prudect name : Rotigotine hydrochlorideSynonyms: CAS NO: 125572-93-2Molecular Formula: C19H25NOS.HClMolecular Weight: 351.93Purity: 98% minSolubility: In

prudect name : Rotigotine hydrochloride Synonyms: CAS NO: 125572-93-2Molecular Formula: C19H25NOS.HClMolecular Weight: 351.93Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.

prudect name : Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.Ribociclib (LEE011) Synonyms: CAS NO: 1211441-98-3Molecular Formula: C23H30N8OMolecular Weight: 434.54Purity: 98% minSolubility: In DMSOStorage: -20…

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