SU-9516 is a selective CDK2 inhibtor with IC50 of 22 nM; less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK etc. IC50 value: 22 nM/40 nM(CDK2/CDK1)

 June 21, 2017

prudect name : SU-9516 is a selective CDK2 inhibtor with IC50 of 22 nM; less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK etc. IC50 value: 22 nM/40…

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prudect name : Sermorelin acetateSynonyms: CAS NO: 114466-38-5Molecular Formula: C149H246N44O42S.C2H4O2Molecular Weight: 3417.97Purity: 98% minSolubility: Storage:

prudect name : Sermorelin acetate Synonyms: CAS NO: 114466-38-5Molecular Formula: C149H246N44O42S.C2H4O2Molecular Weight: 3417.97Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com

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prudect name : SU5402Synonyms: CAS NO: 215543-92-3Molecular Formula: C17H16N2O3Molecular Weight: 296.32Purity: 98% minSolubility: In DMSOStorage:

prudect name : SU5402 Synonyms: CAS NO: 215543-92-3Molecular Formula: C17H16N2O3Molecular Weight: 296.32Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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prudect name : Sodium ceftiofurSynonyms: CAS NO: 104010-37-9Molecular Formula: C19H16N5NaO7S3Molecular Weight: 545.55Purity: 98%Solubility: Storage: −20°C

prudect name : Sodium ceftiofur Synonyms: CAS NO: 104010-37-9Molecular Formula: C19H16N5NaO7S3Molecular Weight: 545.55Purity: 98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless of prognostic indicators and treatment history. Compared with flavopiridol and roscovitine, SNS-032 is more potent, both in inhibition of RNA synthesis and at induction of apoptosis. SNS-032 activity is readily reversible; removal of SNS-032 reactivates RNA polymerase II, which led to resynthesis of Mcl-1 and cell survival.

prudect name : SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless…

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prudect name : SNS-032Synonyms: CAS NO: 345627-92-1Molecular Formula: C17H24N4O2S2.1/2(C4H6O6)Molecular Weight: 455.57Purity: 98% minSolubility: In DMSOStorage:

prudect name : SNS-032 Synonyms: CAS NO: 345627-92-1Molecular Formula: C17H24N4O2S2.1/2(C4H6O6)Molecular Weight: 455.57Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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prudect name : SomatostatinSynonyms: CAS NO: 38916-34-6Molecular Formula: C76H104N18O19S2Molecular Weight: 1637.89Purity: 98% minSolubility: In DMSOStorage:

prudect name : Somatostatin Synonyms: CAS NO: 38916-34-6Molecular Formula: C76H104N18O19S2Molecular Weight: 1637.89Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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Chemical Name: 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride

prudect name : Chemical Name: 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochlorideSB 242084 Synonyms: CAS NO: 181632-25-7Molecular Formula: C21H19ClN4O2.2HClMolecular Weight: 467.78Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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SGI-1776 free base is a selective Pim family kinase inhibitor with IC50 of 7 ¡À 1.8, 363 ¡À 27.6 and 69 ¡À 9.2 nM for Pim-1, Pim-2, and Pim-3, respectively. SGI-1776 is a member of the imidazo[1,2-b]pyridazine chemical class, was selected for its ability to exploit an extended ATP-binding and solvent pocket, thereby making it a selective Pim family kinase inhibitor. Extensive biochemical characterization of SGI-1776 confirmed its specificity for the three isoforms of the Pim family. SGI-1776 is a fairly selective inhibitor of the Pim kinases and can cause a reduction in prostate cancer cell viability and alter overall cytotoxic responses to taxanes. SGI-1776 can disrupt cell cycle progression, induce apoptosis, promote taxane sensitivity, and overcome acquired chemoresistance by inhibiting MDR1 activity in specific prostate cancer models. SGI-1776 induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction. SGI-1776 exhibited inhibitory activity against two other kinases: Flt-3 (IC50=44 nM) and Haspin (IC50= 34 nM).

prudect name : SGI-1776 free base is a selective Pim family kinase inhibitor with IC50 of 7 ¡À 1.8, 363 ¡À 27.6 and 69 ¡À 9.2 nM for Pim-1, Pim-2,…

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SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 ¦ÌM/ 0.22 ¦ÌM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.

prudect name : SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 ¦ÌM/ 0.22 ¦ÌM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport…

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