SNS-314 Mesylate is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50=9.0nM), B (IC50=31nM), and C (IC50=3.4nM). SNS-314 demonstrated remarkable specificity and was found to inhibit only 24 of 219 kinases by 65% greater than that of screening at 1 µM. Histone H3 phosphorylation was potently inhibited by SNS-314 in all 6 cell lines tested with IC50 values ranging from 9 nM in HCT116 cellsto 60 nM in Calu-6 cells .SNS-314 Mesylate also displayed significant anti-tumor activity in mouse xenograft models of human breast (MDA-MB-231), prostate (PC-3), lung (H1299 and Calu-6), ovarian (A2780) carcinomas and melanoma (A375).

 June 21, 2017

prudect name : SNS-314 Mesylate is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50=9.0nM), B (IC50=31nM), and C (IC50=3.4nM). SNS-314 demonstrated remarkable specificity and was found to…

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Salirasib(S-Farnesylthiosalicylic aci) is an S-farnesyl cysteine analog that interferes with docking of active GTP-bound ras at the cell membrane.

prudect name : Salirasib(S-Farnesylthiosalicylic aci) is an S-farnesyl cysteine analog that interferes with docking of active GTP-bound ras at the cell membrane.Salirasib Synonyms: CAS NO: 162520-00-5Molecular Formula: C22H30O2SMolecular Weight: 358.54Purity:…

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prudect name : SL251188Synonyms: CAS NO: 185835-97-6Molecular Formula: C16H17F3N2O5Molecular Weight: 374.31Purity: 98% minSolubility: In DMSOStorage:

prudect name : SL251188 Synonyms: CAS NO: 185835-97-6Molecular Formula: C16H17F3N2O5Molecular Weight: 374.31Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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NSC 74859 (S3I-201) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of the Stat3 beta homodimer. NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ¡À33¦ÌM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3.

prudect name : NSC 74859 (S3I-201) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with…

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SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).

prudect name : SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).SAG (Smo…

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Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A.

prudect name : Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to…

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Macitentan intermediates

prudect name : Macitentan intermediatesSulfamide, N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N’-propyl- Synonyms: CAS NO: 1393813-42-7Molecular Formula: C13H14BrClN4O2SMolecular Weight: Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com

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prudect name : SEP-0372814Synonyms: CAS NO: 1516895-53-6Molecular Formula: C21H21N7Molecular Weight: 371.19Purity: 98% MINSolubility: In

prudect name : SEP-0372814 Synonyms: CAS NO: 1516895-53-6Molecular Formula: C21H21N7Molecular Weight: 371.19Purity: 98% MINSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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prudect name : SCR-1481B1Synonyms: CAS NO: 1174161-86-4Molecular Formula: Molecular Weight: Purity: 98% minSolubility: DMSOStorage: -20¡æ

prudect name : SCR-1481B1 Synonyms: CAS NO: 1174161-86-4Molecular Formula: Molecular Weight: Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com

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SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 inhibited the RK from heat-shocked HeLa cells and osmotically stressed PC12 cells or bacterially expressed CSBP-2 with an IC50 of 0.6 ¦ÌM. SB 203580-induced activation of c-Raf is independent of stress-activated protein kinase 2a/p38 inhibition.

prudect name : SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 inhibited the RK from…

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