KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).

 June 21, 2017

prudect name : KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).It does not affect the activity of several other kinases when tested…

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Chemical Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate

prudect name : Chemical Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylateKB-R7943 mesylate Synonyms: CAS NO: 182004-65-5Molecular Formula: C16H17N3O3S.CH3SO3HMolecular Weight: 427.49Purity: 98% minSolubility: In DMSOStorage: −20°C DX-8951 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521500

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Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively). Ki16425 is a LPA receptor inhibitor with selectivity for LPA1 (Ki = 0.34µM)and LPA3(Ki = 0.93µM)vs. LPA2(Ki = 6.5µM). Ki16425 also inhibited LPA-induced longterm responses, including DNA synthesis and cell migration.

prudect name : Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4,…

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kobe2602 is a novel and effective small-molecule compound inhibiting Ras¨CRaf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras¡¤GTP to c-Raf-1 RBD with a Ki value of 149 ¡À 55 ¦ÌM.

prudect name : kobe2602 is a novel and effective small-molecule compound inhibiting Ras¨CRaf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras¡¤GTP to c-Raf-1 RBD with…

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KPT-276 is an orally bioavailable selective CRM1 inhibitor.KPT-276 results in significant growth inhibition and apoptosis induction in MCL cells.

prudect name : KPT-276 is an orally bioavailable selective CRM1 inhibitor.KPT-276 results in significant growth inhibition and apoptosis induction in MCL cells.KPT-276 Synonyms: CAS NO: 1421919-75-6Molecular Formula: C16H10F8N4OMolecular Weight: 426.26Purity:…

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JDTic is a drug that acts as an opioid antagonist, which is highly selective for the ¦Ê-opioid receptor. JDTic blocks this receptor without affecting the ¦Ì- or ¦Ä-opioid receptors. JDTic is a 4-phenylpiperidine derivative, distantly structurally related to analgesic drugs such as meperidine and ketobemidone, and more closely to the mu opioid antagonist alvimopan, and is structurally distinct from other kappa antagonists such as norbinaltorphimine. JDTic has a very long duration of action, with effects in animals seen for up to several weeks after administration of a single dose, although its binding to the kappa opioid receptor is not irreversible and its long-acting effects are instead caused by altered activity of c-Jun N-terminal kinases. Animal studies suggest that it may produce antidepressant and anxiolytic effects, as well as having possible application in the treatment of addiction to cocaine and morphine.

prudect name : JDTic is a drug that acts as an opioid antagonist, which is highly selective for the ¦Ê-opioid receptor. JDTic blocks this receptor without affecting the ¦Ì- or…

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JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

prudect name : JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C,…

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JW55;JW 55;JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.

prudect name : JW55;JW 55;JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9…

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JZL184 is a useful tool for studying the effects of endogenous 2-AG signaling. JZL184 displays time-dependent inhibition of MAGL and exhibits >300-fold selectivity for MAGL over FAAH in vitro. JZL184 does not interact with CB1 or CB2 receptors and does not inhibit the 2-AG biosynthetic enzymes diacylglycerol lipase-¦Áand diacylglycerol lipase-¦Â, or the arachidonic acid¨Cmobilizing enzyme cytosolic phospholipase A2 group IVA.

prudect name : JZL184 is a useful tool for studying the effects of endogenous 2-AG signaling. JZL184 displays time-dependent inhibition of MAGL and exhibits >300-fold selectivity for MAGL over FAAH…

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JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.

prudect name : JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.JNJ 42041935 Synonyms: CAS NO: 1193383-09-3Molecular Formula: C12H6ClF3N4O3Molecular Weight: 346.65Purity: 98% minSolubility:…

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