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Prucalopride short-term treatment of severe chronic constipation can significantly improve bowel function, reduce symptoms of constipation.

June 21, 2017

prudect name : Prucalopride short-term treatment of severe chronic constipation can significantly improve bowel function, reduce symptoms of constipation.Prucalopride Synonyms: CAS NO: 179474-81-8Molecular Formula: C18H26ClN3O3Molecular Weight: 367.8744Purity: 99%Solubility: In DMSOStorage:…

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Ruxolitinib_Intermediates

prudect name : Ruxolitinib_IntermediatesPyrazole-4-boronic acid pinacol ester Synonyms: CAS NO: 269410-08-4Molecular Formula: C9H15BN2O2Molecular Weight: 194.04Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. PND-1186 did not alter c Src or p130Cas tyrosine phosphorylation in adherent cells, yet functioned to restrain cell movement. Notably, 1.0 ?M PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 ?M PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis

prudect name : PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. PND-1186 did not alter c Src or p130Cas…

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Pimecrolimus caused a strong and dose-dependent inhibition of anti-IgE¨Cinduced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/L pimecrolimus) and of mast cell tryptase (maximally 75%) and a less pronounced inhibition of LTC4 (maximally 32%) and of calcium ionophore plus phorbol myristate acetate¨Cinduced mast cell TNF-¦Á release (90% maximum at 100 nmol/L pimecrolimus).

prudect name : Pimecrolimus caused a strong and dose-dependent inhibition of anti-IgE¨Cinduced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/L pimecrolimus) and…

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PD 184352/CI-1040 is a non-competitive inhibitor of MEK1/2 with a Ki of 300nM in vitro CI-1040 inhibited MEK (as measured by phosphorylated ERK (p-ERK) levels) with a half-maximal inhibitory concentration (IC50) of 100¨C500nM in all cell lines tested

prudect name : PD 184352/CI-1040 is a non-competitive inhibitor of MEK1/2 with a Ki of 300nM in vitro CI-1040 inhibited MEK (as measured by phosphorylated ERK (p-ERK) levels) with a…

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PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP kinase with a Ki of 5.8 nM.Additionally, in a human peripheral blood monocyte assay, PH-797804 inhibits hPBMC TNF, exhibiting IC50 of 3.4 nM. Indeed, PH-797804 revealed exceptionally high specificity against MAP kinases and the related kinases. In cellular assays, PH-797804 demonstrated superior potency and selectivity in good line with the biochemical measurements.

prudect name : PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP…

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I-3065 is a novel potent and selective PI3K p110¦Ä inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110¦Á, p110¦Â, p110¦Ã, DNA-PK and mTOR.

prudect name : I-3065 is a novel potent and selective PI3K p110¦Ä inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110¦Á, p110¦Â, p110¦Ã, DNA-PK and mTOR.PI-3065…

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1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

prudect name : 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-olP7C3 Synonyms: CAS NO: 301353-96-8Molecular Formula: C21H18Br2N2OMolecular Weight: 474.21Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Pelitinib inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.

prudect name : Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby…

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PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.

prudect name : PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.PPQ-102 Synonyms: CAS NO: 931706-15-9Molecular Formula: C26H22N4O3Molecular Weight: 438.48Purity: 98%…

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